Organisms derive the majority of their energy from the Kreb's Cycle, also known as the TCA cycle. The Kreb's Cycle is an aerobic process consisting of eight definite steps. In order to enter the Kreb's Cycle pyruvate must first be converted into Acetyl-CoA by pyruvate dehydrogenase complex found in the mitochondria.

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Kreb Cycle (Citric Acid Cycle, or TCA cycle (tricarboxylic acid cycle)), is a central metabolic pathway where the sequence of biochemical reactions releases energy stored in the form of ATP. The Krebs Cycle takes place in the mitochondria. The Krebs Cycle was discovered by Hans Krebs. The cycle starts with

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Check Kreb cycle steps with diagram, which explains how respiratory chain works to convert substances into energy and how ATP molecules are formed.

The Krebs cycle is a series of redox reactions each catalysed by an enzyme. Firstly, acetyl coA enters the cycle by combining with a 4-carbon compound (called oxaloacetate) to produce a 6-carbon compound (called citrate).

The Krebs cycle—also known as the citric acid cycle—is a critical component of medical education. As a foundational concept in biochemistry, it plays a pivotal role in understanding how cells generate energy, which is essential for everything from muscle contraction to brain function. This blog is an excerpt from the Medical Student Core > Biochemistry > Citric Acid Cycle. This MedStudy Core content was medically reviewed by Tony Hannaman, MD.