Latest articles

1. 1. Genetics and Genomics

   Down Syndrome: How a gene fuels ear infections

   Sedigheh Delmaghani, Aziz El-Amraoui

   The DYRK1A enzyme is a pivotal contributor to frequent and severe episodes of otitis media in Down syndrome, positioning it as a promising target for therapeutic interventions.
2. 1. Chromosomes and Gene Expression

   Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules

   Carlos Moreno-Yruela, Beat Fierz

   Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.
3. 1. Cell Biology

   Aging: Restoring bone healing potential

   Inês Sequeira

   A combination of intermittent fasting and administering Wnt3a proteins to a bone injury can rejuvenate bone repair in aged mice.
4. 1. Developmental Biology

   Brain Development: Single cells tell it all

   Margaret Hines, Elias Oxman ... Irene Zohn

   A new single-cell atlas of gene expression provides insights into the patterning of the neural plate of mice.
5. 1. Computational and Systems Biology

   Cellular Respiration: Mapping mitochondrial aging

   Alessandro Bitto

   Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how aging affects mitochondrial function in mice.
6. 1. Ecology

   Disease Transmission: Interactions between wild pigs and the spread of disease

   Mercury Shitindo

   Tracking wild pigs with GPS devices reveals how their social interactions could influence the spread of disease, offering new strategies for protecting agriculture, wildlife, and human health.
7. 1. Cell Biology

   Cytoskeleton: Rearranging to resist cell death

   Dominik Brokatzky, Serge Mostowy

   Cytoskeleton rearrangements promote formation of a giant structure called a GUVac that stops cells from dying when they become detached from the extracellular matrix.
8. 1. Developmental Biology

   Lung Development: Exploring a complex constellation of signaling pathways

   Nathaniel C Nelson, Matthias C Kugler

   Cells called alveolar myofibroblasts, which have a central role in the development of the lung after birth, receive an orchestrated input from a range of different signaling pathways.
9. 1. Neuroscience

   Locomotion: How vision shapes the paths we choose

   Arthur D Kuo

   A mathematical model can predict the path walkers take through a rugged landscape, including the tendency of people to avoid paths that are too steep, even if it means going farther.
10. 1. Neuroscience

    Cochlear Synaptopathy: Unravelling hidden hearing loss

    Emmanuel Ponsot

    Damage to the synapses connecting hair cells to the auditory nerve leads to undetected hearing impairments.