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Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene .[ 5] [ 6] [ 7] [ 8] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.[ 8]
SMG1 (gene) has been shown to interact with PRKCI [ 9] and UPF1 .[ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000157106 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030655 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 4 (5): 307–13. doi :10.1093/dnares/4.5.307 . PMID 9455477 .
^ Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (June 2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein" . J. Biol. Chem . 276 (25): 22709–14. doi :10.1074/jbc.C100144200 . PMID 11331269 .
^ Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S (March 2007). "Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay" . J. Biol. Chem . 282 (11): 7799–808. doi :10.1074/jbc.M610159200 . PMID 17229728 .
^ a b "Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1" .
^ Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (January 1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo" . Mol. Cell. Biol . 16 (1): 105–14. doi :10.1128/mcb.16.1.105 . PMC 230983 . PMID 8524286 .
^ Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (September 2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay" . Genes Dev . 15 (17): 2215–28. doi :10.1101/gad.913001 . PMC 312771 . PMID 11544179 .
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res . 9 (3): 99–106. CiteSeerX 10.1.1.500.923 . doi :10.1093/dnares/9.3.99 . PMID 12168954 .
Abraham RT (2005). "The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways". DNA Repair (Amst.) . 3 (8–9): 919–25. doi :10.1016/j.dnarep.2004.04.003 . PMID 15279777 .
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Activity Regulation Classification Kinetics Types