Description

Tabula Muris Senis is a comprehensive compendium of single cell transcriptomic data from the model organism Mus musculus comprising more than 500,000 cells from 18 organs and tissues across the mouse lifespan. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence, changes in the activity of metabolic pathways, depletion of stem-cell populations, genomic instability and the role of inflammation as well as other changes in the organism’s immune system. Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.See: https://www.biorxiv.org/content/10.1101/661728v1

Update Frequency

This is the first version of the dataset and it will be updated after the manuscript has been peer reviewed.

License

https://github.com/czbiohub/tabula-muris-senis/blob/master/LICENSE

Documentation

https://github.com/czbiohub/tabula-muris-senis/blob/master/tabula-muris-senis-on-aws.md

Managed By

Chan Zuckerberg Biohub

See all datasets managed by Chan Zuckerberg Biohub.

Contact

If you have questions about the data, you can create an Issue at https://github.com/czbiohub/tabula-muris-senis.

How to Cite

Tabula Muris Senis was accessed on DATE from https://registry.opendata.aws/tabula-muris-senis.

Usage Examples

Tutorials

• Fast queries of scRNAseq datasets with Amazon Athena by Andrew Ang, James Golden, Lisa McFerrin, and Lee Pang
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