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() Medication-Assisted Treatment (MAT) | SAMHSA
U.S. Department of Health & Human Services
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Medication-Assisted Treatment (MAT)

Medication-assisted treatment (MAT), including opioid treatment programs (OTPs), combines behavioral therapy and medications to treat substance use disorders.

NEW: Read all of SAMHSA's Coronavirus Information

Opioid Treatment Program (OTP) Guidance (March 16, 2020) (PDF | 216 KB)

OTP Guidance for Patients Quarantined at Home with the Coronavirus (PDF | 154 KB)

FAQs: Provision of Methadone and Buprenorphine for the Treatment of Opioid Use Disorder in the COVID-19 Emergency (PDF | 137 KB)

Sample OTP COVID-19 FAQs (PDF |341 KB)

The Notification of Enforcement Discretion on Telehealth Remote Communications

DEA Information on Telemedicine (PDF | 103 KB)

Use of Telemedicine While Providing Medication-Assisted Treatment (PDF | 146 KB)

DEA Diversion Control Division COVID-19 Information

TAP 34: Disaster Planning Handbook for Behavioral Health Treatment Programs

About MAT

Medicated-Assisted Treatment (MAT) is the use of FDA-approved medications, in combination with counseling and behavioral therapies, to provide a "whole-patient" approach to the treatment of substance use disorders.

Find information on physical ailments often diagnosed in MAT patients. Also known as common comorbidities, these include viral hepatitis, HIV, and AIDS.

Information and Training Resources

Certifications of OTPs

Find directions to:

Regional OTP Compliance Officers within SAMHSA's Division of Pharmacologic Therapies (DPT) determine whether an OTP is qualified to carry out opioid treatment.

Statutes, Regulations, and Guidelines

MAT for opioid addiction is subject to federal legislation, regulations, and guidelines, including DATA 2000 and federal regulation 42 CFR 8.

Access Model Guidelines for State Medical Boards.

Learn more about:

Medications to Treat Opioid Addiction

There are three medications commonly used to treat opioid addiction:

  • Methadone – clinic-based opioid agonist that does not block other narcotics while preventing withdrawal while taking it; daily liquid dispensed only in specialty regulated clinics
  • Naltrexone – office-based non-addictive opioid antagonist that blocks the effects of other narcotics; daily pill or monthly injection
  • Buprenorphine – office-based opioid agonist/ antagonist that blocks other narcotics while reducing withdrawal risk; daily dissolving tablet, cheek film, or 6-month implant under the skin

Check with your doctor on the right one for you.

Last Updated: 04/30/2020

Medications to Treat
OPIOID ADDICTION

Methadone
Naltrexone
Buprenorphine

Opioid Treatment Program Directory.
Medication for Opioid Overdose - Naloxone

Contact Us

For information on buprenorphine waiver processing, contact the SAMHSA Center for Substance Abuse Treatment (CSAT) at 866-BUP-CSAT (866-287-2728) or infobuprenorphine@samhsa.hhs.gov.

For information about other medication-assisted treatment (MAT) or the certification of opioid treatment programs (OTPs), contact the SAMHSA Division of Pharmacologic Therapies at 240-276-2700. DPT@SAMHSA.HHS.Gov.

For assistance with the Opioid Treatment Program Extranet, contact the OTP helpdesk at OTP-Help@jbsinternational.com or 1-866-348-5741.

Contact SAMHSA’s regional OTP Compliance Officers to determine if an OTP is qualified to provide treatment for substance use disorders.









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