Carbohydrates play a pivotal role in drug discovery and the pharmaceutical industry, however, synthetic methods for C-glycosylation remain challenging. Here, the authors report Zweifel olefination to access C-glycosides selectively by starting from unsaturated glycal derivatives.

The ten-eleven translocation (TET) dioxygenase subfamily catalyse the sequential oxidation of 5-methylcytosine (^5mC) in DNA and belong to the Fe(II)-/2-oxoglutarate (2OG)-dependent dioxygenases that use 2OG and O₂ cofactors to yield succinate and CO_2. Here, the authors profile the TET-catalysed ^5mC DNA oxidation and 2OG decarboxylation using MS and ¹H NMR spectroscopy methods, revealing a high degree of substrate oxidation-independent 2OG turnover in TETs.

Crosslinking mass spectrometry enables the structural analysis of proteins and protein complexes and serves as a powerful tool in protein-protein interaction studies, however, the data analysis of large non-cleavable crosslink studies remains challenging. Here, the authors report an algorithm MS Annika 3.0 for proteome-wide identification of non-cleavable crosslinks showing high sensitivity, accurate FDR estimation and computational performance, uncovering the structure of the C. elegans Box C/D complex.

The ham gene cluster in Burkholderia cenocepacia H111 produces two compounds: the signalling molecule valdiazen as racemate and the antifungal fragin in enantiopure form. Here, the authors demonstrate that the stereodivergence is based on the heterocyclic intermediate dihydrosydnone N-oxide, with both non-enzymatic racemization and enzyme-mediated dynamic kinetic resolution occurring in parallel.

Diluting phosphorescent and thermally activated delayed fluorescence emitter molecules in solid-state host matrices has proven to be a useful strategy to hinder self-quenching mechanisms, but host materials must meet several criteria to enable energy efficient and stable OLEDs. Here, the authors report the synthesis of a series of 1,3,5-oxadiazines from a one-pot interrupted Fischer indolization, and demonstrate that they possess highly desirable characteristics as host materials in deep-blue OLED devices.

Aroma compositions are usually complex mixtures of odor-active compounds exhibiting diverse molecular structures, and assessing or predicting the olfactory qualities of such mixtures is challenging. Here, fast automated analytical assessment tools are combined with the human sensory data of 11 experienced panelists and machine learning algorithms, enabling samples to be distinguished and classified based on their detected molecules, and gaining insights into key molecular structure characteristics and odor descriptors.

Communications Chemistry is pleased to introduce a Collection of articles on the topic of plasmon-mediated chemistry. Here, the Guest Editors discuss different themes within and look towards the future of the field.

Communications Chemistry is pleased to introduce a Collection of research works focused on recent developments within the interdisciplinary field of on-surface synthesis. Here, the Guest Editors highlight key themes and look towards the future of this research field.

Communications Chemistry is delighted to introduce a Collection of articles that combine coacervation with systems chemistry. Here, the Guest Editors of the Collection introduce the importance of research at the interface between these two topics and highlight the current challenges in this area.

Research on the Li₇La₃Zr₂O₁₂ (LLZO)/Li interface is essential for improving the performance of LLZO-based solid-state batteries. In this comment, the authors present an analysis of the key interfacial phenomena at the LLZO/Li interface, highlighting recent developments and unresolved issues.

Dr Yee Hwee Lim currently leads a team of more than 25 researchers in the Chemical Biotechnology and Biocatalysis division at the A*STAR Institute of Sustainability for Chemicals, Energy and Environment (A*STAR ISCE²) to develop integrative technologies at the interface between chemistry, biology, informatics, and engineering for sustainable chemical manufacturing.

Dr Aude Sadet is a junior scientist who conducts research in the Biophysics and Biomedical Applications Laboratory at the Extreme Light Infrastructure of the National Research Institute for Physics in Magurele, Bucharest, Romania.