After two volatile years, FDA approvals in 2024 settled closer to their 10-year average. Will nominated commissioner Marty Makary shake things up, or maintain a steady ship?

Patent protection for therapeutic monoclonal antibodies requires a fundamental shift in strategy following Amgen v. Sanofi, which invalidated broad functional claims for antibody genera in the USA.

Recent patents relating to antibody compositions and methods of use.

SVision-pro enables pairwise genome comparison and improves de novo and somatic structural variant calling.

A supramolecular drug design yields anticoagulants that are rapidly reversible.

mRNA with engineered poly(A) tails produces prolonged higher levels of protein.

AAV vectors form difficult-to-detect concatemers at Cas9 target sites.

Tumor-specific T cell receptors (TCRs) are identified by functional screening of synthetic TCR libraries.

Reference-free integrative analysis of spatial transcriptomics data is achieved with archetype analysis.

A circular RNA aptamer shows therapeutic efficacy in vivo in a psoriasis model.

Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data.

Gene dynamics of concurrent biological processes are unraveled by considering gene trajectories instead of cell trajectories.

Using gene–gene covariance structure to represent cellular neighborhoods improves the integration of single-cell RNA sequencing and spatial transcriptomics data.

An innovative challenge-based and research-driven educational model immerses groups of undergraduate students in the discovery stages of biotech industry research.

Recent moves of note in and around the biotech and pharma industries.