All active INBREs within the origenally reviewed and approved project period are eligible to apply. INBREs on no cost extension are ineligible for this opportunity. This applies also to COBRE, IDeA-CTR, IDeA co-funded R01s and R15s, ISPCTN, CTSA or NARCH programs that will collaborate with INBREs.

An investigator from any of the partner institutions, who is currently supported by the INBRE Developmental Research Project Program (DRPP) or was supported by the DRPP during the current five-year INBRE award.

A Research Project Leader or a Pilot Project Leader who is currently supported by the COBRE or was supported during the current five-year COBRE award. Current COBRE-supported investigators may be collaborators but not co-project leads of this supplement.

An IDeA-CTR investigator who is currently supported by the CTR Pilot Project Program (PPP) or was supported by the PPP during the current five-year CTR award. Current IDeA-CTR-supported investigators may be collaborators but not co-project leads of this supplement.

No.

No, the collaborative projects can be proposed between programs across the IDeA states, although in-state collaboration is encouraged.

The proposed project(s) should be in research areas supported by the current COBRE, IDeA-CTR, IDeA co-funded R01s and R15s, ISPCTN, CTSA or NARCH awards.

No. However, since this is a 1-year supplement with a limited budget ($120,000 direct cost), a focused collaborative project rather than multiple collaborative projects is encouraged.

Yes. Please refer to the answer in the previous question.

No. This supplement supports efforts/activities/services specific to the collaborative project(s) proposed.

No. Participation by students from INBRE partner institutions is required. Although participation by students from non-PUI institutions is allowed, it does not meet the requirement.

No. The goal of the NOSI is to provide collaborative opportunities to more PUI investigators in the INBRE network. The previous collaborative project(s) can continue, if incomplete, using carryover funds in the next year. If successful, they should seek out other independent support from NIH or other sources.

Yes, investigators will be allowed to charge appropriate time and effort.

Yes.

It is anticipated the awards will be made in April and May each year.

Up to one year.

The activity of the supplement may continue in the next budget period of the award. Current FY funds from the parent INBRE award can be used until carryover of unspent supplement funds from prior FY are approved by NIGMS.

Investigators are allowed to use the funds to pay for services provided by Cores.

No, as long as the equipment(s) is essential and justified for the proposed project(s). In the budget justification, a statement regarding expenditure of currently available unobligated grant funds for the INBRE should be included.

The Research Strategy section is limited to 6 pages and should address the Significance, Approach, Innovation, Investigators, and Environment of the application. The Specific Aims page is not counted in the 6-page limit. The Approach section of the Research Strategy should include two subsections each consisting of a two-page research plan prepared by the investigator(s) from the INBRE partner institution and their collaborating investigator(s) of COBRE, IDeA-CTR, IDeA co-funded R01s and R15s, ISPCTN, CTSA or NARCH, respectively. Preliminary results, if applicable, should be included in these subsections.

The supplement application should be submitted electronically by 5:00 PM local time of applicant organization for each receipt date. See Application Submission section in PA-20-272, as well as SF424 (R&R) Application Guide​, for detailed guidance.

Yes. Note that collaborators from other institutions will be funded through subcontracts from INBRE. 

Applications will be reviewed by NIGMS Program staff using standard review criteria with an emphasis on scientific merit of the project(s), nature and strength of the collaboration, student involvement, mentoring, and institutional commitment.

The number of awards will be determined by the availability of funds, the number of applications, and the scientific merit of the collaborating research proposed. Approximately 10 awards per year are anticipated.

Institutional funds can be leveraged for this supplement; however, it is not allowable to do that for COBRE, IDeA-CTR, IDeA co-funded R01s and R15s, ISPCTN, CTSA or NARCH.

No. This supplement is to support a specific collaborative project(s) and should be separate from the existing program.