John M. Chu’s blockbuster film has brought “Wicked”-mania to a new stratosphere.

You never know how she’s going to react and while her large eyes are often sullen and sad, her expression unreadable, Dyrholm’s are wide and bright, verging on the edge of mania.

Kicking off in Manchester on Wednesday, the gigs will be hoping to keep the mania of Brat summer alive well into the winter months.

Their findings, published in Acta Psychiatrica Scandinavica, indicate that it is possible to detect time intervals when patients with bipolar disorder are experiencing depression or mania with high accuracy using data from fitness tracking devices.

One Direction inspired full-on pop mania - stadiums full of screaming teenage fans, thousands camping outside their hotels, 70 million records sold.