Papers by Sandip Chakrabarti
Scientific reports, Apr 3, 2017
This work reports first electrochemical preparation of exceptionally biocompatible, highly crysta... more This work reports first electrochemical preparation of exceptionally biocompatible, highly crystalline, and well exfoliated nitrogen doped graphene nanosheets (eNGS) from carbon nanosheets for the development of mighty platforms in the field of modern biosensing and other biological applications for human welfare. eNGS displayed exceptional biocompatibility. Administration of the as-synthesized eNGS to rat models did not lead to any significant deviation or inimical consequences in its functional observation battery (FOB) tests, GSH levels or the histology of the vital organs of the rat models. The pictomicrographs of myocytes nuclei and myofibrillar for heart, hippocampus (CA1) section for brain, central vein, and hepatocytes for liver and parenchyma, tubules and glomeruli for kidney also remained unaffected. Moreover, the resultant nanoelectrocatalyst displayed enhanced electrochemical performance towards real-time sensing of dopamine (DA) from human urine sample in the presence o...
Synthesis of nitrogen doped graphene nanosheets (NGS) with controlled structure is a burgeoning i... more Synthesis of nitrogen doped graphene nanosheets (NGS) with controlled structure is a burgeoning issue in
the field of materials chemistry. Herein, we for the first time report a novel, green, low-temperature,
hydrothermal synthesis of two dimensional (2D), porous, NGS from carbon nanosheets (CNS) as
precursor materials. Hydrothermal reduction of CNS not only imparts crystallinity to the material but also
results in a substantial removal of oxygen functionalities, forming NGS. The as-synthesized NGS
displayed excellent electrochemical sensing properties with high selectivity and sensitivity for the
detection of dopamine (DA) in human urine samples. NGS can easily distinguish the electrochemical
oxidation peak for DA from that of uric acid (UA), which is a common interferent for DA detection. The
electrochemical oxidation peak current of DA linearly varies within the concentration range of 0.1 to
100 mM, having remarkable sensitivity (2.661 mA mM1) and a lower detection limit upto 100 nM, with a
correlation coefficient (R2) of 0.9880. The separation of electrooxidation peak potential for DA–UA is
extraordinarily high (0.37 0.05 V). In contrast to carbonized carbon material (CCM), reduced graphene
oxide (rGO) and other carbon materials, the current response for NGS is three folds higher at the same
DA concentration with higher electrocatalytic response. Furthermore, superior electrochemical sensitivity
and selectivity along with enhanced electrocatalytic properties of NGS for DA detection is metal/metal
oxide free, which are usually employed for electrode modification to achieve higher current response.
Henceforth, we believe that NGS synthesis offers great promises for creating a revolutionary new class of
nanostructured electrodes for biosensing applications.
The rising incidence of drug resistant diseases has led to an increasing need for developing nove... more The rising incidence of drug resistant diseases has led to an increasing need for developing novel and
efficient antimicrobial products that can counter these infections. We report for the first time, the
exceptional antibacterial activity of N-doped carbon nanosheets (CNS). The antibacterial activity and
mechanism of action of CNS was examined for gram negative E. coli. Based on the cell viability tests,
nucleic acid quantitation, time and concentration dependent antibacterial activity tests and SEM and TEM
micrographs, performed under similar concentration and incubation conditions, the CNS dispersion
shows the highest antibacterial activity, sequentially followed by GO, rGO and CCM, with a loss of cell
viability by 92.1 1.7%. We envision that the physical stress and piercing action caused by sharp “knifeedges”
as well as the presence of heteroatoms in CNS result in the rupturing of the bacterial cell wall,
eventually causing cell death. The high ID/IG ratio (0.99) of CNS is closely related to the formation of
structural and edge plane defects, especially in the case of N-doped carbonaceous materials, which is
one of the key factors in enhancing the antibacterial activity of the material.
We report a bottom-up one-step solvothermal synthesis of thin layered carbon nanosheets (CNSs) by... more We report a bottom-up one-step solvothermal synthesis of thin layered carbon nanosheets (CNSs) by dehydrating glycerol with concentrated sulfuric acid in the presence of melamine. In this synthesis, melamine plays a critical role in the formation of the thin-layered CNS. This CNS was found to be a highly effective adsorption material: its adsorption of methylene blue (MB) is considerably faster than GO with a maximum adsorption capacity of MB at 585 mg g À1 , comparable to most of the other carbon based nanomaterials. † Electronic supplementary information (ESI) available: FESEM, FTIR spectra, atomic percentages, XPS spectra of CNSs, TGA results, dynamic adsorption and removal efficiency of MB, and pseudo-second-order kinetic, linear isotherm plots of Freundlich and Langmuir models. See
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Papers by Sandip Chakrabarti
the field of materials chemistry. Herein, we for the first time report a novel, green, low-temperature,
hydrothermal synthesis of two dimensional (2D), porous, NGS from carbon nanosheets (CNS) as
precursor materials. Hydrothermal reduction of CNS not only imparts crystallinity to the material but also
results in a substantial removal of oxygen functionalities, forming NGS. The as-synthesized NGS
displayed excellent electrochemical sensing properties with high selectivity and sensitivity for the
detection of dopamine (DA) in human urine samples. NGS can easily distinguish the electrochemical
oxidation peak for DA from that of uric acid (UA), which is a common interferent for DA detection. The
electrochemical oxidation peak current of DA linearly varies within the concentration range of 0.1 to
100 mM, having remarkable sensitivity (2.661 mA mM1) and a lower detection limit upto 100 nM, with a
correlation coefficient (R2) of 0.9880. The separation of electrooxidation peak potential for DA–UA is
extraordinarily high (0.37 0.05 V). In contrast to carbonized carbon material (CCM), reduced graphene
oxide (rGO) and other carbon materials, the current response for NGS is three folds higher at the same
DA concentration with higher electrocatalytic response. Furthermore, superior electrochemical sensitivity
and selectivity along with enhanced electrocatalytic properties of NGS for DA detection is metal/metal
oxide free, which are usually employed for electrode modification to achieve higher current response.
Henceforth, we believe that NGS synthesis offers great promises for creating a revolutionary new class of
nanostructured electrodes for biosensing applications.
efficient antimicrobial products that can counter these infections. We report for the first time, the
exceptional antibacterial activity of N-doped carbon nanosheets (CNS). The antibacterial activity and
mechanism of action of CNS was examined for gram negative E. coli. Based on the cell viability tests,
nucleic acid quantitation, time and concentration dependent antibacterial activity tests and SEM and TEM
micrographs, performed under similar concentration and incubation conditions, the CNS dispersion
shows the highest antibacterial activity, sequentially followed by GO, rGO and CCM, with a loss of cell
viability by 92.1 1.7%. We envision that the physical stress and piercing action caused by sharp “knifeedges”
as well as the presence of heteroatoms in CNS result in the rupturing of the bacterial cell wall,
eventually causing cell death. The high ID/IG ratio (0.99) of CNS is closely related to the formation of
structural and edge plane defects, especially in the case of N-doped carbonaceous materials, which is
one of the key factors in enhancing the antibacterial activity of the material.
the field of materials chemistry. Herein, we for the first time report a novel, green, low-temperature,
hydrothermal synthesis of two dimensional (2D), porous, NGS from carbon nanosheets (CNS) as
precursor materials. Hydrothermal reduction of CNS not only imparts crystallinity to the material but also
results in a substantial removal of oxygen functionalities, forming NGS. The as-synthesized NGS
displayed excellent electrochemical sensing properties with high selectivity and sensitivity for the
detection of dopamine (DA) in human urine samples. NGS can easily distinguish the electrochemical
oxidation peak for DA from that of uric acid (UA), which is a common interferent for DA detection. The
electrochemical oxidation peak current of DA linearly varies within the concentration range of 0.1 to
100 mM, having remarkable sensitivity (2.661 mA mM1) and a lower detection limit upto 100 nM, with a
correlation coefficient (R2) of 0.9880. The separation of electrooxidation peak potential for DA–UA is
extraordinarily high (0.37 0.05 V). In contrast to carbonized carbon material (CCM), reduced graphene
oxide (rGO) and other carbon materials, the current response for NGS is three folds higher at the same
DA concentration with higher electrocatalytic response. Furthermore, superior electrochemical sensitivity
and selectivity along with enhanced electrocatalytic properties of NGS for DA detection is metal/metal
oxide free, which are usually employed for electrode modification to achieve higher current response.
Henceforth, we believe that NGS synthesis offers great promises for creating a revolutionary new class of
nanostructured electrodes for biosensing applications.
efficient antimicrobial products that can counter these infections. We report for the first time, the
exceptional antibacterial activity of N-doped carbon nanosheets (CNS). The antibacterial activity and
mechanism of action of CNS was examined for gram negative E. coli. Based on the cell viability tests,
nucleic acid quantitation, time and concentration dependent antibacterial activity tests and SEM and TEM
micrographs, performed under similar concentration and incubation conditions, the CNS dispersion
shows the highest antibacterial activity, sequentially followed by GO, rGO and CCM, with a loss of cell
viability by 92.1 1.7%. We envision that the physical stress and piercing action caused by sharp “knifeedges”
as well as the presence of heteroatoms in CNS result in the rupturing of the bacterial cell wall,
eventually causing cell death. The high ID/IG ratio (0.99) of CNS is closely related to the formation of
structural and edge plane defects, especially in the case of N-doped carbonaceous materials, which is
one of the key factors in enhancing the antibacterial activity of the material.