TRAF2

TRAF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3M0D, 1CA4, 1CA9, 1CZY, 1CZZ, 1D00, 1D01, 1D0A, 1D0J, 1F3V, 1QSC, 3KNV, 3M06, 3M0A
Dynodwyr
Cyfenwau	TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117
Dynodwyr allanol	OMIM: 601895 HomoloGene: 22520 GeneCards: TRAF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sphingolipid binding • lipid binding • CD40 receptor binding • mitogen-activated protein kinase kinase kinase binding • zinc ion binding • signal transducer activity • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • thioesterase binding • enzyme binding • protein phosphatase binding • protein kinase binding • ubiquitin protein ligase binding • transferase activity • tumor necrosis factor receptor binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • TRAF2-GSTP1 complex • AIP1-IRE1 complex • ubiquitin ligase complex • vesicle membrane • cell cortex • membrane raft • CD40 receptor complex • cytoplasmic side of plasma membrane • IRE1-TRAF2-ASK1 complex • nucleoplasm • cytoplasm • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • regulation of apoptotic process • positive regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of JUN kinase activity • negative regulation of glial cell apoptotic process • regulation of tumor necrosis factor-mediated signaling pathway • protein K63-linked ubiquitination • positive regulation of DNA-binding transcription factor activity • tumor necrosis factor-mediated signaling pathway • activation of NF-kappaB-inducing kinase activity • positive regulation of protein homodimerization activity • response to endoplasmic reticulum stress • protein homotrimerization • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • positive regulation of I-kappaB phosphorylation • regulation of JNK cascade • GO:0044257 protein catabolic process • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-2 production • death-inducing signaling complex assembly • positive regulation of T cell cytokine production • protein ubiquitination • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of extrinsic apoptotic signaling pathway • cellular response to nitric oxide • regulation of extrinsic apoptotic signaling pathway via death domain receptors • I-kappaB kinase/NF-kappaB signaling • activation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0072468 signal transduction • protein autoubiquitination • negative regulation of neuron death • programmed necrotic cell death • GO:0097285 apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • protein deubiquitination • protein heterooligomerization • GO:0034622 protein-containing complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7186	n/a
Ensembl	ENSG00000127191	n/a
UniProt	Q12933	n/a
RefSeq (mRNA)	NM_021138	n/a
RefSeq (protein)	NP_066961	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TRAF2 yw TRAF2 a elwir hefyd yn TNF receptor-associated factor 2 a TNF receptor associated factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TRAF2.

• TRAP
• TRAP3
• RNF117
• MGC:45012

Llyfryddiaeth

• "TRAF2 is a Valuable Prognostic Biomarker in Patients with Prostate Cancer. ". Med Sci Monit. 2017. PMID 28855498.
• "New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains. ". Biochim Biophys Acta. 2017. PMID 28499815.
• "Methylation status of TRAF2 is associated with the diagnosis and prognosis of gastric cancer. ". Int J Clin Exp Pathol. 2015. PMID 26823737.
• "TNFR-Associated Factor-2 (TRAF2): Not Only a Trimer. ". Biochemistry. 2015. PMID 26390021.
• "TRAF2 facilitates vaccinia virus replication by promoting rapid virus entry.". J Virol. 2014. PMID 24429366.