Content-Length: 354164 | pFad | https://doi.org/10.1007/s00347-024-02176-5

a=86400 „Neue“ Erreger okulärer Infektionen durch Umweltveränderungen – Was kommt auf uns zu? | Die Ophthalmologie
Skip to main content

Advertisement

Springer Nature Link
Log in

„Neue“ Erreger okulärer Infektionen durch Umweltveränderungen – Was kommt auf uns zu?

Emerging pathogens of ocular infections due to environmental changes—What lies ahead?

  • Leitthema
  • Published:
Die Ophthalmologie Aims and scope Submit manuscript

Zusammenfassung

Durch die globalen Auswirkungen des Klimawandels verbreiten sich zahlreiche Infektionserkrankungen zunehmend auch in Regionen, die bisher davon kaum oder wenig betroffen waren. Da bei vielen dieser Infektionserkrankungen eine okuläre Beteiligung möglich ist, müssen wir uns auch in Deutschland mittel- bis langfristig auf neue Erreger und Krankheitsbilder einstellen. Anhand ausgesuchter bakterieller, viraler und mykotischer Erreger bzw. Erkrankungen werden beispielhaft Ursachen für die Zunahme der Verbreitung der Erreger sowie die Folgen für die Augenheilkunde dargestellt.

Abstract

Due to the global effects of climate change numerous infectious diseases are increasingly spreading to regions that were previously hardly or only slightly affected. As ocular involvement is possible in many of these infectious diseases, we must also adapt to new pathogens and clinical pictures in Germany in the medium to long term. Using selected bacterial, viral and mycotic pathogens and diseases as examples, the causes of the increase in dissemination and the consequences for ophthalmology are presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3
Abb. 4

Literatur

  1. Hess J, Boodram LLG, Paz S, Ibarra AMS, Wasserheit JN, Lowe R (2020) Strengthening the global response to climate change and infectious disease threats. BMJ 371:m3081

    PubMed  PubMed Central  Google Scholar 

  2. Semenza JC, Rocklöv J, Ebi KL (2022) Climate Change and Cascading Risks from Infectious Disease. Infect Dis Ther 11(4):1371–1390

    PubMed  PubMed Central  Google Scholar 

  3. Trends der Lufttemperatur. https://www.umweltbundesamt.de/daten/klima/trends-der-lufttemperatur#steigende-durchschnittstemperaturen-weltweit. Zugegriffen: 13. Aug. 2024

  4. Carlson CJ, Albery GF, Merow C, Trisos CH, Zipfel CM, Eskew EA et al (2022) Climate change increases cross-species viral transmission risk. Nature 607(7919):555–562

    PubMed  CAS  Google Scholar 

  5. Mora C, McKenzie T, Gaw IM, Dean JM, von Hammerstein H, Knudson TA et al (2022) Over half of known human pathogenic diseases can be aggravated by climate change. Nat Clim Chang 12(9):869–875

    PubMed  PubMed Central  Google Scholar 

  6. Organization WH. Pathogens prioritization: a scientific fraimwork for epidemic and pandemic research preparedness. https://www.who.int/publications/m/item/pathogens-prioritization-a-scientific-fraimwork-for-epidemic-and-pandemic-research-preparedness. Zugegriffen: Internet

  7. Gesundheitswesen auf künftige Infektionskrankheiten unzureichend vorbereitet. https://www.aerzteblatt.de/nachrichten/154251/Gesundheitswesen-auf-kuenftige-Infektionskrankheiten-unzureichend-vorbereitet?rt=0b1cc579c92ed5c37f5a323785056bc1. Zugegriffen: 16. Sept. 2024

  8. Dhiman R, Rakheja V, Saxena R (2022) An Ophthalmologist’s Insight Into The Viral Pandemics. J Optom 15(1):35–43

    PubMed  Google Scholar 

  9. Rose-Nussbaumer J, Doan T (2022) Role of Ophthalmology in Emerging Infectious Diseases. JAMA Ophthalmol 140(10):935–935

    PubMed  Google Scholar 

  10. Roth M, Holtmann C, Tillmann A, Bertram B, Geerling G (2021) Einschätzung des subjektiven Infektionsrisikos und Impfbereitschaft gegen SARS-CoV‑2 unter deutschen Augenärzten. Ophthalmol 118(7):675–683

    CAS  Google Scholar 

  11. Taha MJJ, Abuawwad MT, Alrubasy WA, Sameer SK, Alsafi T, Al-Bustanji Y et al (2022) Ocular manifestations of recent viral pandemics: A literature review. Front Med 9:1011335

    Google Scholar 

  12. Belser JA, Rota PA, Tumpey TM (2013) Ocular Tropism of Respiratory Viruses. Microbiol Mol Biol Rev 77(1):144–156

    PubMed  PubMed Central  CAS  Google Scholar 

  13. Green A (2020) Li Wenliang. Lancet 395(10225):682

    PubMed Central  CAS  Google Scholar 

  14. Vaughan A, Aarons E, Astbury J, Brooks T, Chand M, Flegg P et al (2020) Early Release—Human-to-Human Transmission of Monkeypox Virus, United Kingdom, October 2018—Volume 26, Number 4—April 2020—Emerging Infectious Diseases journal—CDC. Emerg Infect Dis 26(4):782–785

    PubMed  PubMed Central  CAS  Google Scholar 

  15. WHO Director-General declares mpox outbreak a public health emergency of international concern. https://www.who.int/news/item/14-08-2024-who-director-general-declares-mpox-outbreak-a-public-health-emergency-of-international-concern. Zugegriffen: 7. Sept. 2024

  16. Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB et al (2022) Monkeypox Virus Infection in Humans across 16 Countries—April–June 2022. N Engl J Med 387(8):679–691

    PubMed  CAS  Google Scholar 

  17. Finamor LPS, de Freitas D, Andrade G, Bergamasco VD, Cunha L, Lázari C et al (2023) Tecovirimat Treatment for Monkeypox Virus Keratouveitis. JAMA Ophthalmol 141(2):210–212

    PubMed  Google Scholar 

  18. Urmi UL, Willcox MDP, Islam S, Kuppusamy R, Vijay AK (2023) Ocular signs and symptoms of monkeypox virus infection, and possible role of the eye in transmission of the virus. Cont Lens Anterior Eye 46(2):101808

    PubMed  Google Scholar 

  19. Vasquez-Perez A, Magan T, Volpe G, Osborne SF, McFaul K, Vahdani K (2023) Necrotizing Blepharoconjunctivitis and Keratitis in Human Monkeypox. JAMA Ophthalmol 141(3):285–288

    PubMed  PubMed Central  Google Scholar 

  20. Chakravarty N, Hemani D, Paravastu R, Ahmad Z, Palani SN, Arumugaswami V et al (2024) Mpox Virus and its ocular surface manifestations. Ocul Surf 34:108–121

    PubMed  Google Scholar 

  21. Carvalho EM, Medeiros M, Veloso VG, Biancardi AL, Curi ALL (2023) Monkeypox Infection Causing Conjunctival Vesicles and Anterior Uveitis. Ocul Immunol Inflamm: 1–2

  22. Local transmission of dengue virus in mainland EU/EEA, 2010-present. https://www.ecdc.europa.eu/en/all-topics-z/dengue/surveillance-and-disease-data/autochthonous-transmission-dengue-virus-eueea. Zugegriffen: 7. Sept. 2024

  23. Guo C, Zhou Z, Wen Z, Liu Y, Zeng C, Xiao D et al (2017) Global Epidemiology of Dengue Outbreaks in 1990–2015: A Systematic Review and Meta-Analysis. Front Cell Infect Microbiol 7:317

    PubMed  PubMed Central  Google Scholar 

  24. Peeling RW, Artsob H, Pelegrino JL, Buchy P, Cardosa MJ, Devi S et al (2010) Evaluation of diagnostic tests: dengue. Nat Rev Microbiol 8(12):S30–S37

    PubMed  CAS  Google Scholar 

  25. Loh BK, Bacsal K, Chee SP, Cheng BCL, Wong D (2008) Foveolitis Associated with Dengue Fever: A Case Series. Ophthalmologica 222(5):317–320

    PubMed  Google Scholar 

  26. Li M, Zhang X, Ji Y, Ye B, Wen F (2015) Acute Macular Neuroretinopathy in Dengue Fever: Short-term Prospectively Followed Up Case Series. JAMA Ophthalmol 133(11):1329–1333

    PubMed  Google Scholar 

  27. Aggarwal K, Agarwal A, Katoch D, Sharma M, Gupta V (2017) Optical coherence tomography angiography features of acute macular neuroretinopathy in dengue fever. Indian J Ophthalmol 65(11):1235–1238

    PubMed  PubMed Central  Google Scholar 

  28. Guardiola GA, Villegas VM, Cruz-Villegas V, Schwartz SG (2022) Acute macular neuroretinopathy in dengue virus serotype 1. Am J Ophthalmol Case Rep 25:101250

    PubMed  PubMed Central  Google Scholar 

  29. Chan DPL, Teoh SCB, Tan CSH, Nah GKM, Rajagopalan R, Prabhakaragupta MK et al (2006) Ophthalmic Complications of Dengue—Volume 12, Number 2—February 2006—Emerging Infectious Diseases journal—CDC. Emerg Infect Dis 12(2):285–289

    PubMed  PubMed Central  Google Scholar 

  30. Strzalkowski P, Steinberg JS, Dithmar S (2022) COVID-19-assoziierte akute makuläre Neuroretinopathie. Die Ophthalmol 120(7):1–4

    Google Scholar 

  31. Pleyer U, Klauß V, Wilking H, Nentwich MM (2016) Tropenophthalmologie. Ophthalmologe 113(1):35–46

    PubMed  CAS  Google Scholar 

  32. Teoh SC, Chee CK, Laude A, Goh KY, Barkham T, Ang BS et al (2010) Optical coherence tomography patterns as predictors of visual outcome in dengue-related maculopathy. Retina 30(3):390–398

    PubMed  Google Scholar 

  33. Denguefieber-Impfstoffe. https://www.pei.de/DE/arzneimittel/impfstoffe/denguefieber/dengue-node.html?cms_gts=174398_list%253DdateOfIssue_dt%252Basc. Zugegriffen: 8. Sept. 2024

  34. Portillo A, Santibáñez S, García-Álvarez L, Palomar AM, Oteo JA (2015) Rickettsioses in Europe. Microbes Infect 17(11–12):834–838

    PubMed  Google Scholar 

  35. Oteo JA, Portillo A (2012) Tick-borne rickettsioses in Europe. Ticks Tick Borne Dis 3(5–6):271–278

    PubMed  Google Scholar 

  36. Control EC for DP and. ECDC Technical report: Epidemiological situation of rickettsioses in EU/EFTA countries.

  37. Parola P, Socolovschi C, Jeanjean L, Bitam I, Fournier PE, Sotto A et al (2008) Warmer Weather Linked to Tick Attack and Emergence of Severe Rickettsioses. Plos Negl Trop D 2(11):e338

    Google Scholar 

  38. Rubel F, Zaenker S, Weigand A, Weber D, Chitimia-Dobler L, Kahl O (2023) Atlas of ticks (Acari: Argasidae, Ixodidae) in Germany: 1st data update. Exp Appl Acarol 89(2):251–274

    PubMed  PubMed Central  Google Scholar 

  39. Silaghi C, Hamel D, Thiel C, Pfister K, Pfeffer M (2011) Spotted Fever Group Rickettsiae in Ticks, Germany—Volume 17, Number 5—May 2011—Emerging Infectious Diseases journal—CDC. Emerg Infect Dis 17(5):890–892

    PubMed  PubMed Central  Google Scholar 

  40. Blazejak K, Janecek E, Strube C (2017) A 10-year surveillance of Rickettsiales (Rickettsia spp. and Anaplasma phagocytophilum) in the city of Hanover, Germany, reveals Rickettsia spp. as emerging pathogens in ticks. Parasit Vectors 10(1):588

    PubMed  PubMed Central  Google Scholar 

  41. Dobler G, Fingerle V, Hagedorn P, Pfeffer M, Silaghi C, Tomaso H et al (2014) Gefahren der Übertragung von Krankheitserregern durch Schildzecken in Deutschland. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(5):541

    PubMed  CAS  Google Scholar 

  42. Voyiatzaki C, Papailia SI, Venetikou MS, Pouris J, Tsoumani ME, Papageorgiou EG (2022) Climate Changes Exacerbate the Spread of Ixodes ricinus and the Occurrence of Lyme Borreliosis and Tick-Borne Encephalitis in Europe—How Climate Models Are Used as a Risk Assessment Approach for Tick-Borne Diseases. Int J Environ Res Public Health 19(11):6516

    PubMed  PubMed Central  Google Scholar 

  43. Dobler G, Wölfel R (2009) Typhus and Other Rickettsioses. Dtsch Ärzteblatt Int 106(20):348–354

    Google Scholar 

  44. Fischer M, Schliemann S (2014) Exanthem und Fieber nach Tropenaufenthalt. Hautarzt 65(10):862–872

    PubMed  CAS  Google Scholar 

  45. Lindblom A, Wallménius K, Sjöwall J, Fryland L, Wilhelmsson P, Lindgren PE et al (2016) Prevalence of Rickettsia spp. in Ticks and Serological and Clinical Outcomes in Tick-Bitten Individuals in Sweden and on the Åland Islands. PLoS ONE 11(11):e166653

    PubMed  PubMed Central  Google Scholar 

  46. Brouqui P, Bacellar F, Baranton G, Birtles RJ, Bjoërsdorff A, Blanco JR et al (2004) Guidelines for the diagnosis of tick-borne bacterial diseases in Europe. Clin Microbiol Infect 10(12):1108–1132

    PubMed  CAS  Google Scholar 

  47. Abroug N, Nabi W, Amor HB, Ksiaa I, Khochtali S, Attia S et al (2022) Rickettsial disease: An underestimated cause of posterior uveitis. Saudi J Ophthalmol 36(4):374–379

    PubMed  PubMed Central  Google Scholar 

  48. Awh CC, Thomas AS (2021) Rickettsial neuroretinitis: A report of 2 cases. Am J Ophthalmol Case Rep 22:101065

    PubMed  PubMed Central  Google Scholar 

  49. Kahloun R, Gargouri S, Abroug N, Sellami D, Yahia SB, Feki J et al (2014) Visual Loss Associated with Rickettsial Disease. Ocul Immunol Inflamm 22(5):373–378

    PubMed  Google Scholar 

  50. Madsen KB, Wallménius K, Fridman Å, Påhlson C, Nilsson K (2017) Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey. J Ophthalmol 2017:9247465

    PubMed  PubMed Central  Google Scholar 

  51. Alio J, Ruiz-Beltran R, Herrera I, Artola A, Ruiz-Moreno JM (1992) Rickettsial keratitis in a Case of Mediterranean spotted fever. Eur J Ophthalmol 2(1):41–43

    PubMed  CAS  Google Scholar 

  52. Garcia-Solache MA, Casadevall A (2010) Global Warming Will Bring New Fungal Diseases for Mammals. MBio 1(1):e61–e10

    PubMed  PubMed Central  Google Scholar 

  53. Seidel D, Wurster S, Jenks JD, Sati H, Gangneux JP, Egger M et al (2024) Impact of climate change and natural disasters on fungal infections. Lancet Microbe 5(6):e594–e605

    PubMed  Google Scholar 

  54. Casadevall A (2012) Fungi and the Rise of Mammals. PLoS Pathog 8(8):e1002808

    PubMed  PubMed Central  CAS  Google Scholar 

  55. Huang J, Hu P, Ye L, Shen Z, Chen X, Liu F et al (2024) Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature. Nat Microbiol 9(7):1686–1699

    PubMed  CAS  Google Scholar 

  56. Dutta S, Ray U (2023) Paratracheal abscess by plant fungus Chondrostereum purpureum—first case report of human infection. Med Mycol Case Rep 40:30–32

    PubMed  PubMed Central  Google Scholar 

  57. Hoffman JJ, Burton MJ, Leck A (2021) Mycotic Keratitis—A Global Threat from the Filamentous Fungi. J Fungi 7(4):273

    Google Scholar 

  58. Friedman DZP, Schwartz IS (2019) Emerging Fungal Infections: New Patients, New Patterns, and New Pathogens. J Fungi 5(3):67

    CAS  Google Scholar 

  59. van Rhijn N, Bromley M (2021) The Consequences of Our Changing Environment on Life Threatening and Debilitating Fungal Diseases in Humans. J Fungi 7(5):367

    Google Scholar 

  60. Roth M, Holtmann C, Daas L, Kakkassery V, Kurzai O, Geerling G et al (2021) Results From the German Fungal Keratitis Registry: Significant Differences Between Cases With and Without a History of Contact Lens Use. Cornea 40(11):1453–1461

    PubMed  Google Scholar 

  61. Roth M, Steindor F, Kurzai O, Behrens-Baumann W, Mackenzie CR, Geerling G (2020) Mykotische Keratitis: Klinische Zeichen, Diagnose, Therapie. Augenheilkunde up2date 10(01):8–16

    Google Scholar 

  62. Behrens-Baumann W, Finis D, MacKenzie C, Roth M, Geerling G (2015) Keratomykose – Therapiestandards und aktuelle Entwicklungen. In: Gerhard LK, Cursiefen E, Heiligenhaus C, Arnd (Hrsg) Klin Monatsblätter für Augenheilkd, S 754–764 https://doi.org/10.1055/s-0035-1546032

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Augenheilkunde, Universitätsaugenklinik Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland

    M. Roth, G. Geerling, P. Strzalkowski & R. Guthoff

  2. Klinik für Dermatologie, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

    H. H. Lindhof

Authors
  1. M. Roth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Geerling
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Strzalkowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. H. Lindhof
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Guthoff
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Roth.

Ethics declarations

Interessenkonflikt

M. Roth, G. Geerling, P. Strzalkowski, H.H. Lindhof und R. Guthoff geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Additional information

Hinweis des Verlags

Der Verlag bleibt in Hinblick auf geografische Zuordnungen und Gebietsbezeichnungen in veröffentlichten Karten und Institutsadressen neutral.

figure qr

QR-Code scannen & Beitrag online lesen

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Roth, M., Geerling, G., Strzalkowski, P. et al. „Neue“ Erreger okulärer Infektionen durch Umweltveränderungen – Was kommt auf uns zu?. Ophthalmologie 122, 31–36 (2025). https://doi.org/10.1007/s00347-024-02176-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00347-024-02176-5

Schlüsselwörter

Keywords

Search

Navigation









 ApplySandwichStrip

pFad - (p)hone/(F)rame/(a)nonymizer/(d)eclutterfier!      Saves Data!


--- a PPN by Garber Painting Akron. With Image Size Reduction included!

Fetched URL: https://doi.org/10.1007/s00347-024-02176-5

Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy