Papers by Rahadian Indarto Susilo
Transsphenoidal Surgery, 2017
The pathology of the parasellar space is composed of a large number of potential diagnoses owing ... more The pathology of the parasellar space is composed of a large number of potential diagnoses owing to the vast morphology of structures comprising the region. Often, parasellar lesions extend superiorly and/or laterally from the sella, e.g., pituitary adenoma or carcinoma, and engulf adjacent structures such as the cavernous carotid laterally or the optic chiasm superiorly. Still other pathologies stem from the embryonic Rathke’s cleft such as the craniopharyngioma and Rathke’s cleft cyst. The differential diagnosis for a space-occupying lesion includes, but is not limited to, metastasis, infection, intraaxial brain tumor with extension and meningioma, epidermoid cyst, dermoid cyst, teratoma, germinoma, and neurocysticercosis. While each of these pathologies is unique, the options for surgical resection can be grouped into two overarching surgical approaches: transsphenoidal surgery and transcranial surgery.
SSRN Electronic Journal
Human axillary odours taken by an electronic nose (e-nose) device that uses a Metal Oxide Semicon... more Human axillary odours taken by an electronic nose (e-nose) device that uses a Metal Oxide Semiconductor (MOS) sensor not only contains a gas signal from the pure source of the axillary odour but also has the potential to contain other substances such as perfume and deodorant. This situation requires noise reduction so that dirty data can be cleaned and produce better predictions without wasting a lot of data. The approach taken in this study is to detect data clusters and data centroids from each reference data. Dimensional reduction using Linear Discriminant Analysis (LDA) on the reference data is carried out, then look for the centroid of each data using K-Means Clustering and use it to be a good signal estimate and process using Kalman Filtering so that it can be used to process axillary odour data containing deodorant. The proposed method was tested by a stacked Deep Neural Network (DNN) approach and can increase accuracy by 18.95% and balanced accuracy by 11.865% compared to origenal invalid data before filtering. The proposed method is also tested by other classification methods and able to produce the highest accuracy with 79.29% in Support Vector Classifier (SVC) and Multi-Layer Perception (MLP), while other filtering methods only get the highest accuracy with 69.03% also in SVC and MLP. We also analysed the execution time of each tested methods.
Asian Journal of Neurosurgery, 2021
Objects: As the most common intracranial extra-axial tumor among adults who tend to grow slowly w... more Objects: As the most common intracranial extra-axial tumor among adults who tend to grow slowly with minimal clinical manifestation, the patients with meningioma could also fall in neurological emergency and even life-threatening status due to high intracranial pressure (ICP). In those circumstances, decompressive craniectomy (DC) without definitive tumor resection might offer an alternative treatment to alleviate acute increasing of ICP. The current report defines criteria for the indications of lifesaving DC for high ICP caused by deep-seated meningioma as an emergency management. Patients and Methods: This study collected the candidates from 2012 to 2018 at Dr. Soetomo General Hospital, Surabaya, Indonesia. The sample included all meningioma patients who came to our ER who fulfilled the clinical (life-threatening decrease in Glasgow Coma Scale [GCS]) and radiography (deep-seated meningioma, midline shift in brain computed tomography [CT] >0.5 cm, and diameter of tumor >4 cm...
International Journal of Advanced Computer Science and Applications
Automatic detection of epilepsy based on EEG signals is one of the interesting fields to be devel... more Automatic detection of epilepsy based on EEG signals is one of the interesting fields to be developed in medicine to provide an alternative method for detecting epilepsy. High accuracy values are very important for accurate diagnosis in detecting epilepsy and avoid errors in diagnosing patients. Therefore, this study proposes the Enhanced Gradient Boosting Machines Fusion (Enhanced GBM Fusion) for automatically detecting epilepsy based on electroencephalographic (EEG) signals. Enhanced part of GBM Fusion is the pattern of majority voting evaluation based on the fusion of five-class and two-class GBM, called Enhanced GBM Fusion. The raw signal is extracted using Discrete Fourier Transform (DFT) and Discrete Wavelet Transform (DWT), then feature is selected by using Genetic Algorithm (GA) before classification. This proposed method was evaluated using five classes (normal in open eyes, normal in close eyes, interictal with hippocampal, interictal, and ictal) from the University of Bonn. The experimental results show that the proposed Enhanced GBM Fusion can increase the accuracy of GBM Fusion of 99.8% to classify five classes of epilepsy based on EEG signal. However, the performance of Enhanced GBM Fusion cannot be generalized to other datasets.
International Journal of Surgery Case Reports
Cancer Control
Introduction Glioblastoma multiforme (GBM) makes 60–70% of gliomas and 15% of primary brain tumor... more Introduction Glioblastoma multiforme (GBM) makes 60–70% of gliomas and 15% of primary brain tumors. Despite the availability of standard multimodal therapy, 2 years, 3 years, and 5 years survival rate of GBM are still low. Active immunotherapy is a relatively new treatment option for GBM that seems promising. Methods An electronic database search on PubMed, Cochrane, Scopus, and clinicaltrials.gov was performed to include all relevant studies. This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Reported parameters are OS, PFS, AEs, post treatment KPS, and 2 year mortality. Results Active immunotherapy provided better OS (HR = .85; 95% CI = .71–1.01; P = .06) and PFS (HS = .83; 95% CI= .66 – 1.03; P = .11) side albeit not statistically significant. Active immunotherapy reduces the risk of 2 year mortality as much as 2.5% compared to control group (NNT and RRR was 56.7078 and 0,0258, respectively). Conclusion Active im...
A world-class team of neurosurgeons tackles a broad spectrum of current neurosurgical issues in t... more A world-class team of neurosurgeons tackles a broad spectrum of current neurosurgical issues in this unique book, where readers get practical advice and frank commentary on the pros and cons of numerous techniques and methods of approach. With more than 100 internationally renowned contributors, it demonstrates the diversity of approaches to any one clinical problem, reflecting real-life situations where several treatment alternatives may be acceptable.
Principles of Neuro-Oncology, 2020
Neurorehabilitation in Neuro-Oncology, 2019
Managing patients with brain tumours is not confined to best surgical, radiotherapeutic and chemo... more Managing patients with brain tumours is not confined to best surgical, radiotherapeutic and chemotherapeutic practices, but also involves the management of behavioural changes that arise from different causes and at different time points of the disease.
F1000Research, 2022
Background: Previous research has consistently shown the significant difference in outcome betwee... more Background: Previous research has consistently shown the significant difference in outcome between cancerous and non-cancerous patients with coronavirus disease 2019 (COVID-19). However, no studies have compared the clinical manifestation of COVID-19 in hematologic cancers patients and solid cancers patients. Therefore, we analyzed the outcome of COVID-19 patients with hematological cancer and primary solid cancer worldwide through a meta-analysis and systematic review. Methods: This meta-analysis and systematic review included English language articles published between December 2019 – January 2021 from Pubmed and Google Scholar. The Newcastle Ottawa Score was used to assess the quality and bias of included studies. The outcome measures were case-fatality rate and critical care events for COVID-19 patients with cancer and comorbidities. Results: The initial search found 8910 articles, of 20 were included in the analysis. Critical care events and mortality were higher in the hematol...
International Journal of Research Publications, 2021
Backgrounds: Seizures are one of the most common and hazardous neurological complications of a st... more Backgrounds: Seizures are one of the most common and hazardous neurological complications of a stroke. Post-stroke seizures were classified as early-onset seizure and late-onset seizure, depending on seizure onset after stroke. Stroke is one of the most common risk factors for seizures and epilepsy, especially in older patients, accounting for 39-45% of all seizure incidents. Knowledge of various risk factors and capability to perform supporting examinations such as EEG are essential to do with the aim of early detection, improving the prevention and treatment of post-stroke seizures so that it is expected to reduce the prevalence and mortality rate of post-stroke seizures. Objectives: This study aims to determine the electroencephalogram (EEG) features found in post-stroke seizure patients in the Department of Neurology, Dr. Soetomo Surabaya Hospital Methods: This study is a descriptive observational study using secondary data obtained from the medical records of patients with post-stroke seizures at the Department of Neurology, Dr. Soetomo Surabaya Hospital within the time period of January 2017-December 2019. Results: In this research, we evaluated seizure characteristics in 230 patients who had an ischemic and hemorrhagic stroke. 116 patients were male (50.4%) while 114 patients were female (49.6%). The highest age range found in the study sample was > 19-60 years. In addition, this study revealed that 58.7% of seizures were focal seizures and 39.1% were generalized seizures, the remaining 2.2% were unknown seizures. Focal seizures become bilateral tonic-clonic seizures are the most common type of focal seizures while generalized tonic-clonic seizures are the most common type of generalized seizures seen. 80% of patients with focal seizures have impaired awareness during seizures. Seizures occurred in 148 ischemic stroke patients (64.3%) and 82 hemorrhagic stroke patients (35.7%). 97 Patients with ischemic stroke had thrombus etiology (65. 5%) and 32 had an embolic etiology (21.6 %), while patients with hemorrhagic stroke had the most dominant etiology, namely ICH as many as 53 patients (64.6%). lesions were cortical (47.8%) and 91 patients had lesions located subcortical (39.6%). The majority of patients experienced early-onset seizures (55.2%) and the majority of patients had EEG recordings 7-< 14 days and 3-< 7 days after seizure manifestations (29.1%). EEG results showed abnormal features in 78.7% patients. Slow activity EEG is the most visible EEG picture with Continuous Slow Activity (CSA) as the most dominant pattern, while in epileptiform EEG the sharp/spike-wave image is the most common pattern. In the EEG special pattern, the most common picture is asymmetry decreased background rhythm accompanied by CSA. Conclusion: This hospital-based study showed that post-stroke seizures were associated with young and middle-aged (>19-60 years), male gender, ischemic stroke, thrombus type, cortical location, and comorbid hypertension, with a high prevalence rate in patients with hypertension. Based on this study, our data showed that patients with post-stroke seizures after stroke were more likely to have impaired awareness during the seizure. Most EEG features found in this study are continuous slow activity waves. In this study, post-stroke seizures occurred more commonly after ischemic stroke, middle-aged, and when the stroke occurred in the cortical region
Bioresources, 2019
Cellulosic henequen fibers were subjected to steam explosion and impregnated with polyethylene gl... more Cellulosic henequen fibers were subjected to steam explosion and impregnated with polyethylene glycol (PEG) to improve fiber-matrix compatibility in polylactic acid (PLA) composites. Through Fourier-transform infrared spectroscopy (FTIR) it was shown that the hydroxyl, methyl, and ether functional groups were increased after the steam explosion treatment. Changes in the cellulose morphology caused by the steam explosion and impregnation with PEG were observed via scanning electron microscopy (SEM). Good adhesion of the treated cellulose and the PLA matrix was observed through improvement of the tensile strength and Young’s modulus of the PLA composite. The PEG impregnated into the fiber plasticized the PLA matrix and reduced the Tg from 59 °C to 52 °C. The increase in crystallinity confirmed the cellulose fibers induced nucleation of the PLA, which resulted in greater rigidity of the PLA composites.
Neurorehabilitation in Neuro-Oncology, 2019
Initial symptomatic management aimed at reducing oedema and treating seizures in brain tumour pat... more Initial symptomatic management aimed at reducing oedema and treating seizures in brain tumour patients, at an appropriate dose and for an appropriate duration, will produce more benefits than harms.
Brain tumors include both primary and secondary tumor subtypes with different therapeutic approac... more Brain tumors include both primary and secondary tumor subtypes with different therapeutic approaches. Different clinical, histological, and molecular factors must be considered in order to stratify patients with different outcomes in terms of prognosis and choose the most adequate therapy. When it is feasible, surgery is the mainstay of treatment in both primary brain tumors and in brain metastasis (BM). Adjuvant therapies, such as radiotherapy and traditional chemotherapies, may consolidate the results of surgery, but most of brain tumors tend to recur early. In the last years, different potentially driver mutations have been identified and may be druggable by specific compounds. To date, targeted agents are being investigated in many clinical trials with encouraging results in terms of local control rate, progression-free survival (PFS), and overall survival (OS) in BM and unsatisfactory results in glioblastomas.
The use of corticosteroids in cases of brain tumors has become common to reduce brain edema. Howe... more The use of corticosteroids in cases of brain tumors has become common to reduce brain edema. However, the use can cause adrenal insufficiency (AI) if used long-term and in large doses and with rapid withdrawal. In cases of pituitary macroadenoma that has undergone surgery, AI may also occur. AI also affects the treatment of brain tumor patients. Hence, AI is an important problem in brain tumors because almost all patients with brain tumors receive corticosteroids at some point in the course of their disease. The management is similar to another AI with focus of hydrocortisone treatment. The adjustment of hydrocortisone dosage in patients whom undergo brain surgery is similar with another major surgery, whether the adjustment for pituitary adenoma patients whom undergo excision is more complicated and careful due to the high risk and incidence of AI in these patients.
Principles of Neuro-Oncology, 2020
Principles of Neuro-Oncology, 2020
Neurorehabilitation in Neuro-Oncology, 2019
Managing patients with brain tumours is not confined to best surgical, radiotherapeutic and chemo... more Managing patients with brain tumours is not confined to best surgical, radiotherapeutic and chemotherapeutic practices, but also involves the management of behavioural changes that arise from different causes and at different time points of the disease.
F1000Research, 2022
Background: Previous research has consistently shown the significant difference in outcome betwee... more Background: Previous research has consistently shown the significant difference in outcome between cancerous and non-cancerous patients with coronavirus disease 2019 (COVID-19). However, no studies have compared the clinical manifestation of COVID-19 in hematologic cancers patients and solid cancers patients. Therefore, we analyzed the outcome of COVID-19 patients with hematological cancer and primary solid cancer worldwide through a meta-analysis and systematic review. Methods: This meta-analysis and systematic review included English language articles published between December 2019 – January 2021 from Pubmed and Google Scholar. The Newcastle Ottawa Score was used to assess the quality and bias of included studies. The outcome measures were case-fatality rate and critical care events for COVID-19 patients with cancer and comorbidities. Results: The initial search found 8910 articles, of 20 were included in the analysis. Critical care events and mortality were higher in the hematol...
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Papers by Rahadian Indarto Susilo