Papers by JUAN FELIPE AVENDAÑO HERRERA
International Journal of Environmental Research and Public Health, 2021
Business organisations are subject to high pressure to ensure their sustainability and competitiv... more Business organisations are subject to high pressure to ensure their sustainability and competitiveness. In the case of healthcare institutions, moreover, there are unique characteristics where human resource management is of vital importance. The workforce in these institutions is at a critical moment where the shortages of qualified staff, burnout, or job dissatisfaction represent some of the detrimental aspects for the performance of the organisation, and more importantly, they diminish the quality of patient care. The promotion of organisational commitment is positioned as one of the tools that organisations have to face this problem. This paper aims to increase knowledge about research trends that analyse organisational commitment in healthcare institutions. To this end, using bibliometric techniques, a sample of 448 publications on this subject from journals indexed in Web of Science between 1992 and 2020 is analysed. The results obtained suggest a growing interest in this subj...
Frontiers in Behavioral Neuroscience, 2021
Understanding behavioral systems as emergent systems comprising the environment and organism subs... more Understanding behavioral systems as emergent systems comprising the environment and organism subsystems, include spatial dynamics as a primary dimension in natural settings. Nevertheless, under the standard approaches, the experimental analysis of behavior is based on the single response paradigm and the temporal distribution of discrete responses. Thus, the continuous analysis of spatial behavioral dynamics is a scarcely studied field. The technological advancements in computer vision have opened new methodological perspectives for the continuous sensing of spatial behavior. With the application of such advancements, recent studies suggest that there are multiple features embedded in the spatial dynamics of behavior, such as entropy, and that they are affected by programmed stimuli (e.g., schedules of reinforcement) at least as much as features related to discrete responses. Despite the progress, the characterization of behavioral systems is still segmented, and integrated data ana...
Journal of Open Innovation: Technology, Market, and Complexity, 2021
The purpose of this paper is to analyze the literature on Gender and Company Executives with the ... more The purpose of this paper is to analyze the literature on Gender and Company Executives with the purpose of identifying lines on which future research could be directed in order to eradicate gender differences in the decision-making bodies of companies. A bibliometric study has been carried out on the Web of Science collection, which, after a series of filters, has given rise to a sample of 144 articles from 1992 to 2018. Keywords and bibliographic references were the units of analysis used. With this information, bibliometric maps have been created applying the methodology of co-word and co-cite, clustering, and visualization techniques. The results suggest that this is an emerging scientific area not yet sufficiently developed, hinting at new research related to topics, such as career, gender diversity and performance, gender and leadership, organizational behavior and mobility, and gender and ethics. The emergence of the concept of “glass cliff” has been detected in the literatur...
Journal of Open Innovation: Technology, Market, and Complexity, 2020
Family firms make a significant contribution to wealth creation. Despite the proliferation of lar... more Family firms make a significant contribution to wealth creation. Despite the proliferation of large corporations, the model remains in place. The peculiarities of the company-family relationship mean that these organizations are managed in a particular way and differently from those with a non-family composition. In recent decades, the literature on family firms has been considerable, but research related to the sustainability of this type of business is in the development phase and shows little maturity. This paper analyses the content of publications that set the trend in research on the sustainability of family firms. Bibliometric techniques are used to obtain the sample (135 docs.) of journals indexed in Web of Science (WoS) between the dates 2003 and 2019. The results suggest that the interest in sustainability in family firms is still relatively recent, barely a decade old. The most central theme has been Socioemotional-Wealth. The analysis of content points mainly to the proc...
Sustainability, 2020
Two-thirds of the world’s private companies are family owned. It is an organizational model that,... more Two-thirds of the world’s private companies are family owned. It is an organizational model that, despite the arrival of large corporations, remains and is still totally in place. The survival of these organizations is not easy, and is conditioned by multiple factors. The research that addresses the sustainability of family businesses is numerous and has been conducted from multiple disciplines. This document investigates the trends in scientific production related to family businesses and their sustainability, using bibliometric techniques and SciMAT software. A total of 286 articles were analysed between 2003 and 2019 from the journals indexed in the Web of Science (WoS). The results suggest that, although there is a growing interest in the study of the sustainability of family businesses, there is instability in the centrality of the topics, which denotes the existence of a wide margin of development. The most influential and trend-setting themes emerge mainly concentrated in thr...
Lenguaje, 2013
Este artículo presenta los referentes conceptuales que dan soporte al diseño de un instrumento ob... more Este artículo presenta los referentes conceptuales que dan soporte al diseño de un instrumento observacional para caracterizar la competencia informacional en estudiantes universitarios. Estos referentes se basan en la semiótica estructural (Greimas, 1989, Alvarado, 2007) y en una comprensión más situada de carácter histórico y cultural de esta competencia. Se concibe el instrumento como un dispositivo de orden superior en cuanto conduce a los sujetos a adoptar una posición de observadores de sí mismos (Navarro, 1995). Los resultados resaltan el carácter situado de las prácticas de acceso, evaluación y uso de fuentes de información por cuanto el instrumento toma en cuenta los contextos, los sujetos y los lenguajes.
Odontología Sanmarquina, 2014
La angina de Ludwig es una celulitis rápidamente progresiva que compromete bilateralmente los esp... more La angina de Ludwig es una celulitis rápidamente progresiva que compromete bilateralmente los espacios submaxilar, sublingual y submentoniano; y que se origena principalmente por infecciones periapicales de las segundas y terceras molares mandibulares. Debido a la rápida progresión del cuadro, que en algunos casos puede incluso poner en peligro la vida del paciente, es sumamente importante conocer los criterios necesarios para realizar un diagnóstico oportuno de la angina de Ludwig, el cual nos permita brindar el tratamiento más adecuado para detener la progresión del cuadro y prevenir la aparición de complicaciones potencialmente mortales.
Revista Venezolana De Computacion, Jan 30, 2015
Resumen: Una Revisión Documental Sistemática (RDS) permite extraer conocimiento sobre un tema de ... more Resumen: Una Revisión Documental Sistemática (RDS) permite extraer conocimiento sobre un tema de investigación; esto se hace mediante preguntas adecuadas, a partir del gran volumen de información disponible en internet. RDS se enfoca en una pregunta de investigación que trata de identificar, evaluar, seleccionar y sintetizar evidencias de investigaciones de alta calidad relevantes para esa pregunta. El objetivo principal del trabajo es realizar una RDS en el tema de la Ingeniería del Dominio (ID) de Líneas de Productos de Software Orientados a Servicios (LPSOS), quien combina los enfoques de Líneas de Productos de Software (LPS) y de Arquitecturas Orientadas a Servicios o del inglés Service-Oriented Architecture (SOA). Esta investigación pretende determinar trabajos recientes existentes en la literatura en cuanto a actividades, artefactos y técnicas para un proceso de desarrollo del dominio, según Björner y de análisis del dominio según Pohl et al.. Como resultado de esta revisión se detectó, combinando los enfoques mencionados, que las fases principales de un proceso general de ID para LPSOS son: análisis, diseño e implementación, inspiradas en las fases definidas por Pohl et al. para la ID en un contexto de LPS. Dentro de estas fases se identificaron las actividades, artefactos y técnicas más usadas en la práctica. Estos resultados serán utilizados para definir un proceso sistemático de Análisis de Dominio para LPSOS, que además contemplará el tratamiento de requisitos de calidad, aspecto relevante para un contexto de producción industrial de software y no tratado sistemáticamente en los enfoques revisados.
Enfermería Clínica, 2016
Patient-centered healthcare is currently one of the most pursued goals in health services. It is ... more Patient-centered healthcare is currently one of the most pursued goals in health services. It is necessary to ensure a sufficient level of cooperative and coordinated work between different providers and settings, including family and social and community resources. Clinical integration occurs when the care provided by health professionals and providers is integrated into a single coherent process through different professions using shared guidelines and protocols. Such coordination can be developed at three levels: macro, which involves the integration of one or more of the three basic elements that support health care (the health plan, primary care and specialty care), with the aim of reducing fragmentation of care; meso, where health and social services are coordinated to provide comprehensive care to elderly and chronic patients; and micro, aimed to improve coordination in individual patients and caregivers. The implementation of new roles, such as Advanced Practice Nursing, along with improvements in family physicians' problem-solving capacity in certain processes, or modifying the place of provision of certain services are key to ensure services adapted to the requirements of chronic patients.
Transportation Research Part C: Emerging Technologies, 2014
The rapid-growth of smartphones with embedded navigation systems such as GPS modules provides new... more The rapid-growth of smartphones with embedded navigation systems such as GPS modules provides new ways of monitoring traffic. These devices can register and send a great amount of traffic related data, which can be used for traffic state estimation. In such a case, the amount of data collected depends on two variables: the penetration rate of devices in traffic flow (P) and their data sampling frequency (z). Referring to data composition as the way certain number of observations is collected, in terms of P and z, we need to understand the relation between the amount and composition of data collected, and the accuracy achieved in traffic state estimation. This was accomplished through an in-depth analysis of two datasets of vehicle trajectories on freeways. The first dataset consists of trajectories over a real freeway, while the second dataset is obtained through microsimulation. Hypothetical scenarios of data sent by equipped vehicles were created, based on the composition of data collected. Different values of P and z were used, and each unique combination defined a specific scenario. Traffic states were estimated through two simple methods, and a more advanced one that incorporates traffic flow theory. A measure to quantify data to be collected was proposed, based on travel time, number of vehicles, penetration rate and sampling frequency. The error was below 6% for every scenario in each dataset. Also, increasing data reduced variability in data count estimation. The performance of the different estimation methods varied through each dataset and scenario. Since the same number of observations can be gathered with different combinations of P and z, the effect of data composition was analyzed (a trade-off between penetration rate and sampling frequency). Different situations were found. In some, an increase in penetration rate is more effective to reduce estimation error than an increase in sampling frequency, considering an equal increase in observations. In other areas, the opposite relationship was found. Between these areas, an indifference curve was found. In fact, this curve is the solution to the optimization problem of minimizing the error given any fixed number of observations. As a general result, increasing sampling frequency (penetration rate) is more beneficial when the current sampling frequency (penetration rate) is low, independent of the penetration rate (sampling frequency).
Plant Cell, Tissue and Organ Culture (PCTOC), 2015
Long-term cell cultures were used in coffee to study the cytological, genetic and epigenetic chan... more Long-term cell cultures were used in coffee to study the cytological, genetic and epigenetic changes occurring during cell culture ageing. The objective was to identify the mechanisms associated with somaclonal variation (SV). Three embryogenic cell lines were established in Coffea arabica (2n = 4x = 44) and somatic seedlings were regenerated after 4, 11 and 27 months. Phenotyping and AFLP, MSAP, SSAP molecular markers were performed on 199 and 124 plants, respectively. SV were only observed from the 11 and 27-month-old cultures, affecting 30 and 94 % of regenerated plants, respectively. Chromosome counts performed on 15 plants showed that normal plants systematically displayed normal chromosome numbers and that, conversely, aneuploidy (monosomy) was systematically found in variants. The allopolyploid structure of C. arabica allowed aneuploid cells to survive and regenerate viable plants. No polymorphic fragments were observed between the AFLP and SSAP electrophoretic profiles of mother plants and those of the in vitro progeny. Methylation polymorphism was low and ranged between 0.087 and 0.149 % irrespective of the culture age. The number of methylation changes per plant-normal or variant-was limited and ranged from 0 (55-80 % of the plants) to 4. The three cell lines showed similar SV rate increases during cell culture ageing and produced plants with similar molecular patterns indicating a non random process. The results showed that cell culture ageing is highly mutagenic in coffee and chromosomal rearrangements are directly linked to SV. Conversely, the analysis of methylation and transposable elements changes did not reveal any relation between the epigenetic patterns and SV.
Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto
Proceeding of the 6th international conference on Mobile systems, applications, and services - MobiSys '08, 2008
Automotive traffic monitoring using probe vehicles with Global Positioning System receivers promi... more Automotive traffic monitoring using probe vehicles with Global Positioning System receivers promises significant improvements in cost, coverage, and accuracy. Current approaches, however, raise privacy concerns because they require participants to reveal their positions to an external traffic monitoring server. To address this challenge, we propose a system based on virtual trip lines and an associated cloaking technique. Virtual trip lines are geographic markers that indicate where vehicles should provide location updates. These markers can be placed to avoid particularly privacy sensitive locations. They also allow aggregating and cloaking several location updates based on trip line identifiers, without knowing the actual geographic locations of these trip lines. Thus they facilitate the design of a distributed architecture, where no single entity has a complete knowledge of probe identities and fine-grained location information. We have implemented the system with GPS smartphone clients and conducted a controlled experiment with 20 phone-equipped drivers circling a highway segment. Results show that even with this low number of probe vehicles, travel time estimates can be provided with less than 15% error, and applying the cloaking techniques reduces travel time estimation accuracy by less than 5% compared to a standard periodic sampling approach.
Biomédica, 2010
Introducción. El TP53 es un gen supresor de tumores localizado en la región cromosómica 17p13.1; ... more Introducción. El TP53 es un gen supresor de tumores localizado en la región cromosómica 17p13.1; controla el ciclo celular y se encuentra alterado en cerca de 50% de todas las neoplasias. Objetivos. Determinar las aneuploidías del cromosoma 17 y la deleción en el locus 17p13.1 del gen TP53, en diversos tumores sólidos primarios utilizando la técnica FISH-bicolor. Materiales y métodos. Se analizaron 38 muestras de diversos tipos de tumores sólidos primarios. Todas las muestras se disociaron mecánica y enzimáticamente con colagenasa al 0,2%, antes de la obtención de los núcleos interfásicos. La técnica de FISH-bicolor se realizó en núcleos interfásicos, mediante sondas marcadas directamente con fluorocromos para el centrómero del cromosoma 17 (CEP 17; señal verde; VYSIS) y para el locus específico del gen TP53 (LSI 17p13.1; señal naranja; VYSIS). Resultados. Se encontró que 63% (24/38) de las muestras tenían aneuploidías del cromosoma 17. La monosomía fue la aneuploidía más frecuente (75%; 18/24), seguida de la trisomía (17%; 4/24); la nulisomía y la tetrasomía fueron menos frecuentes. El 89,5% (34/38) de los casos presentaron deleción del gen TP53. Sólo cuatro casos fueron normales para el número de copias del cromosoma 17 y del gen TP53. El estudio histopatológico mostró que la mayoría de las muestras eran tumores malignos. Conclusiones. La aneuploidía del cromosoma 17 y la deleción en el locus 17p13.1 del gen TP53 son alteraciones muy frecuentes en los tumores sólidos. La técnica FISH-bicolor permite detectar simultáneamente alteraciones cromosómicas numéricas y estructurales en núcleos interfásicos. Palabras clave: aneuploidía, deleción cromosómica, gen Tp53, hibridación fluorescente in situ, neoplasias, inestabilidad cromosómica, heterogeneidad genética. Detection of chromosome 17 aneuplody and TP53 gene deletion in a broad variety of solid tumors by dual-color fluorescence in situ hybridization (FISH) Introduction. TP53 is a tumor suppressor gene located on chromosome 17p13.1. This gene is essential for the control of cell cycle and has been found altered in about 50% of all tumor types. Objective. The presence of aneuploidy of chromosome 17 and TP53 gene deletion at 17p13.1 locus was determined in primary solid tumors using the dual-color FISH (fluorescence in situ hybridization). Materials and methods. Thirty-eight samples consisted of several types of primary solid tumors. All samples were mechanically and enzymatically disaggregated with 0.2% collagenase prior to obtaining interphase nuclei. The dual-color FISH was performed using direct fluorescent labeling probes for the chromosome 17 centromere (green signal) and for the TP53 gene locus-specific (orange signal). Results. Characteristic aneuploidy on chromosome 17 was found in 63% (24/38) of the samples. Monosomy occurred most frequently (75%, 18/24), followed by trisomy (17%, 4/24); nullisomy and tetrasomy were less frequent. TP53 gene deletion was found in 89.5% (34/38) of cases. Only four tumors were normal for copy number of chromosome 17 and TP53 gene. The histopathologic study showed that most of the samples were malignant tumors. Conclusions. Aneuploidy of chromosome 17 and deletion at 17p13.1 locus of TP53 gene were genetic alterations found to be very frequent in solid tumors. The dual-color FISH was able to detect both numerical and structural chromosomal abnormalities in interphase nuclei.
Psychiatry Research: Neuroimaging, 2009
Studies in cocaine-dependent human subjects have shown differences in white matter on diffusion t... more Studies in cocaine-dependent human subjects have shown differences in white matter on diffusion tensor imaging (DTI) compared to non-drug using controls. It is not known whether the FA differences seen on DTI in white matter regions of cocaine-dependent humans result from a preexisting predilection for drug use or purely from cocaine abuse. To study the effect of cocaine on brain white matter, DTI was performed on 24 rats after continuous infusion of cocaine or saline for 4 weeks, followed by brain histology. Voxel-based morphometry analysis showed 18% decrease in fractional anisotropy (FA) in the splenium of corpus callosum (CC) in cocaine-administered animals relative to saline controls (P = 0.0001). On histology, significant increase in neurofilament expression (125%, P=0.0044) and decrease in myelin basic protein (40%, P = 0.031) was observed in the same region in cocaine-administered animals. This study supports the hypothesis that chronic cocaine use alters white matter integrity in human CC. Unlike humans, where the FA in the genu differed between cocaine users and non-users, the splenium was affected in rats. These differences between rodent and human findings could be due to a several factors that include differences in the brain structure and function between species and/or the dose, timing, and duration of cocaine administration.
Journal of Neurotrauma, 2010
Longitudinal in vivo proton magnetic resonance spectroscopy (1 H-MRS) and immunohistochemistry we... more Longitudinal in vivo proton magnetic resonance spectroscopy (1 H-MRS) and immunohistochemistry were performed to investigate the tissue degeneration in traumatically injured rat spinal cord rostral and caudal to the lesion epicenter. On 1 H-MRS significant decreases in N-acetyl aspartate (NAA) and total creatine (Cr) levels in the rostral, epicenter, and caudal segments were observed by 14 days, and levels remained depressed up to 56 days post-injury (PI). In contrast, the total choline (Cho) levels increased significantly in all three segments by 14 days PI, but recovered in the epicenter and caudal, but not the rostral region, at 56 days PI. Immunohistochemistry demonstrated neuronal cell death in the gray matter, and reactive astrocytes and axonal degeneration in the dorsal, lateral, and ventral white-matter columns. These results suggest delayed tissue degeneration in regions both rostrally and caudally from the epicenter in the injured spinal cord tissue. A rostralcaudal asymmetry in tissue recovery was seen both on MRI-observed hyperintense lesion volume and the Cho, but not NAA and Cr, levels at 56 days PI. These studies suggest that dynamic metabolic changes take place in regions away from the epicenter in injured spinal cord.
Journal of Molecular Evolution, 1995
DNA sequence segments conserved since divergence of Escherichia coli and Bacillus subtilis were i... more DNA sequence segments conserved since divergence of Escherichia coli and Bacillus subtilis were identified, using the GenBank sequence database. Chromosomal locations of the conserved segments were compared between the two bacteria, and the following three features were observed. (1) Although the two genomes are nearly identical in size, chromosomal arrangements of the conserved segments are considerably different from each other. (2) In many cases, chromosomal locations of a conserved segment in the two species have deviated from each other by a multiple of 60 °. (3) There are many instances in which a contiguous segment in one genome is split into two or more segments located at distinct positions in the other genome, and these split segments were found to tend to lie on the E. coli or B. subtilis genome separated by distances of multiples of 60 °. On the basis of these observations, genome organizations of the two bacteria were discussed in terms of genome doublings as well as random chromosomal rearrangements.
Journal of Advanced Nursing, 2012
This protocol outlines a review and qualitative study to determine the models and effectiveness o... more This protocol outlines a review and qualitative study to determine the models and effectiveness of Advanced Practice Nursing developed for the health care of people over 65 years in different settings (hospital care, home care, outpatients' care, and nursing homes) and to identify the ingredients of the interventions developed by Advanced Practice Nursing in the field of geriatric care. Numbers of nurses in advanced roles have increased internationally in conjunction with research to determine their effectiveness. Nevertheless, in older people, evidence of advanced practice roles remains scattered, and there is little synthesis of evidence, and therefore it is not easy to visualize the different practice models, their components, and their impact. Study protocol with two phases: a systematic review and a qualitative study. First phase: Depending on comparability of studies, meta-analysis will be undertaken. If so, results will be summarized in relative and absolute measures or mean difference, depending on the type of outcome. Sensitivity and heterogeneity analyses will be performed. Second phase: a content analysis will be carried out of the interventions identified in the systematic review, and they will be contrasted with the contents of the Nursing Interventions Classification. Finally, this matching will be submitted to expert consensus using a Delphi technique. Approval from the Ethics Committee was obtained in July 2010 and funding was obtained in March 2011. The identification of components of Advanced Practice Nursing models and evidence of their effectiveness will contribute to designing more grounded nursing services for older people. Additionally, the categorization of Advanced Practice Nursing interventions through Nursing Interventions Classification would permit comparisons to be made between settings or between healthcare systems.
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Papers by JUAN FELIPE AVENDAÑO HERRERA