Papers by Andrea A. Rosolia
Ophthalmology and therapy, Mar 18, 2023
Yellow subthreshold micropulse laser (YSML) is a retinal laser capable of inducing a biologic res... more Yellow subthreshold micropulse laser (YSML) is a retinal laser capable of inducing a biologic response without causing thermal damage to the targeted tissue. The 577-nm YSML is delivered to the retina abiding by different protocols in which wavelength, power, duration, spot size and number of spots can be properly set to achieve the most effective and safe treatment response in various chorioretinal disorders. The ultrashort trains of power modulate the activation of the retinal pigment epithelium cells and intraretinal cells, such as Müller cells, causing no visible retinal scars. Subthreshold energy delivered by YSML stimulates the production of the heat-shock proteins, highly conserved molecules that protect cells against any sort of stress by blocking apoptotic and inflammatory pathways that cause cell damage. YSML treatment allows resorption of the subretinal fluid in central serous chorioretinopathy and intraretinal fluid in various conditions including diabetic macular edema, postoperative cystoid macular edema and other miscellaneous conditions. YSML also seems to modulate the development and progression of reticular pseudodrusen in dry age-related macular degeneration. The aim of this review is to discuss and summarize the safety and efficacy of YSML treatment in retinal diseases.
Life, May 24, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Research Square (Research Square), Jan 3, 2023
Background: To evaluate how Ectopic Inner Foveal Layers (EIFL) affect macular morphology and func... more Background: To evaluate how Ectopic Inner Foveal Layers (EIFL) affect macular morphology and function after idiopathic Epiretinal Membrane (ERM) and internal limiting membrane (ILM) peeling by the means of Best-Corrected Visual Acuity (BCVA), Optical Coherence Tomography (OCT), Microperimetry (MP-1) and Multifocal Electroretinogram (mfERG). Methods: patients underwent pars plana vitrectomy with ILM and ERM peeling. They were retrospectively followed-up for 12 months and allocated into two groups basing on baseline EIFL presence (group 1) or absence (group 2). Central Retinal Thickness (CRT) and BCVA were measured and compared pre-and post-operatively at 1, 4 and 12 months, whereas Fixation Stability (FS), Macular Sensitivity (MS) and mfERG responses were confronted at baseline and 12 months. Results: In group 1 BCVA improved (p<0.05) at 4 and 12 months (Mean difference (MD)=0.14 (SE=0.04); MD=0.13 (SE=0.05), respectively) as well as in group 2 (MD=0.31 (SE=0.07): MD=0.41 (SE=0.08), respectively). CRT did not change in group 1, whereas it decreased (p<0.05) in group 2 at 4 and 12 months (MD=-73.13-SE=23.56; MD=-76.20-SE=23.56). MS showed no changes in both groups after surgery. FS did not change in group 1, whereas group 2 improved (p<0.05) in either FS2° (+8.91±13.97) and FS4° (+4.33±3.84) at 12 months. MfERG P1 wave did not improve in group 1, while group 2 improved
Journal of Clinical Medicine, Jul 2, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Journal of Clinical Medicine, Jul 30, 2022
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
RETINAL Cases & Brief Reports, 2021
Purpose: To describe the steps leading to the development and progression of macular neovasculari... more Purpose: To describe the steps leading to the development and progression of macular neovascularization (MNV) in angioid streaks. Methods: The study was designed as retrospective, longitudinal case series. Patients with angioid streaks were investigated by means of multimodal imaging, including fundus autofluorescence and structural optical coherence tomography. Main outcome measures were hyperreflective foci and MNV progression steps. Results: Overall, 40 eyes (20 patients) affected by angioid streaks were evaluated. Over the follow-up, five eyes of five patients developed MNV. The mean follow-up was of 1.6 years. The mean number of anti–vascular endothelial growth factor injections was 4.35 ± 1.4. Mean best-corrected visual acuity was 0.53 ± 0.38 LogMAR at the MNV onset, improving to 0.42 ± 0.40 LogMAR at the end of the follow-up (P > 0.05). Intraretinal hyperreflective foci onset and coalescence represented the first alterations occurring before the onset of the MNV. Anti–vasc...
Ophthalmology and therapy, Jun 9, 2023
Introduction: Foveal eversion (FE) is a recently described optical coherence tomography (OCT) fin... more Introduction: Foveal eversion (FE) is a recently described optical coherence tomography (OCT) finding associated with negative outcome in diabetic macular edema. The main goal of the present study was to investigate the role of the FE metric in the diagnostic workup of retinal vein occlusion (RVO). Methods: This study was a retrospective, observational case series. We included 168 eyes (168 patients) affected by central RVO (CRVO) and 116 eyes (116 patients) affected by branch (RVO). We collected clinical and imaging data from CRVO and BRVO eyes affected by macular edema with a minimum follow-up of 12 months. On structural OCT, we classified FE as pattern 1a, characterized by thick vertical intraretinal columns, pattern 1b, presenting thin vertical intraretinal lines, and pattern 2, showing no signs of vertical lines in the context of the cystoid macular edema. For statistical purposes, we considered data collected at baseline, after 1 year and at the last follow-up. Results: The mean follow-up was 40 ± 25 months for CRVO eyes and 36 ± 24 months for BRVO eyes. We found FE in 64 of 168 CRVO eyes (38%) and in 25 of 116 BRVO eyes (22%). Most of the eyes developed FE during the follow-up. For CRVO eyes, we found 6 eyes (9%) with pattern 1a, 17 eyes (26%) with pattern 1b and 41 eyes (65%) with pattern 2. Of those BRVO eyes with FE, we found 8 eyes (32%) with pattern 1a ? 1b and 17 eyes (68%) with pattern 2. In both CRVO and BRVO the presence of FE was significantly associated with higher persistence of macular edema and worse outcome, with FE pattern 2 representing the most severe condition. Remarkably, FE patterns 1a and 1b were characterized by BCVA stability over the follow-up, whereas FE pattern 2 showed significant bestcorrected visual acuity (BCVA) worsening at the end of the follow-up. Conclusions: FE can be considered a negative prognostic biomarker in RVO, associated with higher persistence of macular edema and worse visual outcome. Müller cell impairment might represent the pathogenic mechanism leading to the loss of macular structural support and impairment of fluid homeostasis.
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Papers by Andrea A. Rosolia