International Journal of Production Research, 2010
In today's economic environment, manufacturing organisations compete against ... more In today's economic environment, manufacturing organisations compete against each other as part of supply chains (SC). As both the SC strategic level and production floor operational level are interdependent, a misalignment between them has a deep impact on the performance of the manufacturing organisation. For this reason, in this paper we develop an analytical expression of the impact such misalignment
RAZÃO DE HEDGE ÓTIMA DE MÍNIMO MPI (MOMENTO PARCIAL INFERIOR) NO MERCADO FUTURO DE BOI GORDO NA B... more RAZÃO DE HEDGE ÓTIMA DE MÍNIMO MPI (MOMENTO PARCIAL INFERIOR) NO MERCADO FUTURO DE BOI GORDO NA BM&F PEDRO VALENTIM MARQUES; JOÃO GOMES MARTINES-FILHO; JOSÉ CÉSAR CRUZ-JÚNIOR; ESALQ-USP PIRACICABA -SP -BRASIL cesarcruzjr@hotmail.com APRESENTAÇÃO ORAL Comercialização, Mercados e Preços Razão de hedge ótima de mínimo MPI (momento parcial inferior) no mercado futuro de boi gordo na BM&F Grupo de Pesquisa: Comercialização, Mercados e Preços
We also characterize which are the stable regions in a convex cone, i.e., second order minima of ... more We also characterize which are the stable regions in a convex cone, i.e., second order minima of perimeter under a volume constraint. From this it follows that the isoperimetric regions in a convex cone are the euclidean balls centered at the vertex intersected with the cone.
Objectives. To investigate the ability of bone marrow (BM)-derived mesenchymal stromal cells (BM-... more Objectives. To investigate the ability of bone marrow (BM)-derived mesenchymal stromal cells (BM-MSCs) in suppressing the proliferation of stimulated lymphocytes across a range of conditions including autologous BM-MSCs derived from autoimmune disease (AD) patients. Methods. In vitro cultures of BM-MSCs from healthy donors and AD patients were established and characterized by their differentiation potential into adipocytes and osteoblasts, and their fibroblast-colony-forming unit (CFU-F) ability and phenotype by flow cytometry. BM-MSCs (irradiated and non-irradiated) from healthy and AD patients were tested for their ability to suppress the in vitro proliferation of autologous and allogeneic peripheral blood mononuclear cells (PBMC) (from healthy donors and patients suffering from various ADs) stimulated with anti-CD3" antibody alone or in combination with anti-CD28 antibody. The antiproliferative effect of the BM-MSCs from healthy donors was tested also on transformed B-cell lines as a model of non-antigenstimulated lymphocytes. Results. BM-MSCs from healthy donors and AD patients reduced the proliferation of autologous and allogeneic PBMCs by up to 90% in a cell dose-dependent fashion. The immunosuppression was independent of the proliferation of the BM-MSCs and was also effective on already proliferating cells. It was independent also of the clinical activity of AD. An MSC dose-dependent pattern of suppression of proliferation was observed also with transformed B-cell lines, similar to that observed with proliferating PBMC. Conclusions.The BM-MSCs exhibit extensive anti-proliferative properties against lymphocytes under different conditions. This property might offer a form of immunomodulatory cellular therapy for AD patients if further confirmed in animal models.
International Journal of Production Research, 2010
In today's economic environment, manufacturing organisations compete against ... more In today's economic environment, manufacturing organisations compete against each other as part of supply chains (SC). As both the SC strategic level and production floor operational level are interdependent, a misalignment between them has a deep impact on the performance of the manufacturing organisation. For this reason, in this paper we develop an analytical expression of the impact such misalignment
RAZÃO DE HEDGE ÓTIMA DE MÍNIMO MPI (MOMENTO PARCIAL INFERIOR) NO MERCADO FUTURO DE BOI GORDO NA B... more RAZÃO DE HEDGE ÓTIMA DE MÍNIMO MPI (MOMENTO PARCIAL INFERIOR) NO MERCADO FUTURO DE BOI GORDO NA BM&F PEDRO VALENTIM MARQUES; JOÃO GOMES MARTINES-FILHO; JOSÉ CÉSAR CRUZ-JÚNIOR; ESALQ-USP PIRACICABA -SP -BRASIL cesarcruzjr@hotmail.com APRESENTAÇÃO ORAL Comercialização, Mercados e Preços Razão de hedge ótima de mínimo MPI (momento parcial inferior) no mercado futuro de boi gordo na BM&F Grupo de Pesquisa: Comercialização, Mercados e Preços
We also characterize which are the stable regions in a convex cone, i.e., second order minima of ... more We also characterize which are the stable regions in a convex cone, i.e., second order minima of perimeter under a volume constraint. From this it follows that the isoperimetric regions in a convex cone are the euclidean balls centered at the vertex intersected with the cone.
Objectives. To investigate the ability of bone marrow (BM)-derived mesenchymal stromal cells (BM-... more Objectives. To investigate the ability of bone marrow (BM)-derived mesenchymal stromal cells (BM-MSCs) in suppressing the proliferation of stimulated lymphocytes across a range of conditions including autologous BM-MSCs derived from autoimmune disease (AD) patients. Methods. In vitro cultures of BM-MSCs from healthy donors and AD patients were established and characterized by their differentiation potential into adipocytes and osteoblasts, and their fibroblast-colony-forming unit (CFU-F) ability and phenotype by flow cytometry. BM-MSCs (irradiated and non-irradiated) from healthy and AD patients were tested for their ability to suppress the in vitro proliferation of autologous and allogeneic peripheral blood mononuclear cells (PBMC) (from healthy donors and patients suffering from various ADs) stimulated with anti-CD3" antibody alone or in combination with anti-CD28 antibody. The antiproliferative effect of the BM-MSCs from healthy donors was tested also on transformed B-cell lines as a model of non-antigenstimulated lymphocytes. Results. BM-MSCs from healthy donors and AD patients reduced the proliferation of autologous and allogeneic PBMCs by up to 90% in a cell dose-dependent fashion. The immunosuppression was independent of the proliferation of the BM-MSCs and was also effective on already proliferating cells. It was independent also of the clinical activity of AD. An MSC dose-dependent pattern of suppression of proliferation was observed also with transformed B-cell lines, similar to that observed with proliferating PBMC. Conclusions.The BM-MSCs exhibit extensive anti-proliferative properties against lymphocytes under different conditions. This property might offer a form of immunomodulatory cellular therapy for AD patients if further confirmed in animal models.
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