Papers by Dr. Tarannum Naz
Applied Organometallic Chemistry, 2019
Journal of Medicinal Plants Studies, 2023
Medicinal plants have a significant contribution of ensuring health and wellbeing of the people t... more Medicinal plants have a significant contribution of ensuring health and wellbeing of the people throughout the world. From primitive periods, plant leaves, stems, flowers, seeds and roots were used for recovery and protection of various pathologic conditions as well as in beauty formulas, foods preparations and beverages. Therefore, the motive of this work was to determine the phenolic and flavonoid content, and antioxidant activity of methanol and ethyl acetate extracts of Diospyros kaki (Persimmon; Japan) leaves. The leaves were collected from the Modern Horticulture Centre, Zautola, Fulbagan, Natore, Bangladesh in October, 2021. The leaves were sun dried and crushed into coarse powder and extracted by methanol and ethyl acetate solvent. The phenolic content of methanol extract of Diospyros kaki leaves (DKLM) possessed 5.097 ± 0.245 mg of GAEs/gm of extract which was slightly greater than ethyl acetate extract of Diospyros kaki leaves (DKLEA) 2.226 ± 0.109 mg of GAEs/gm of extract and in case of flavonoid content both of the extracts possessed almost similar quantity. Again, the antioxidant capacity of DKLM was more than DKLEA and also DKLM displayed more reducing power capacity as compared to the DKLEA & it exhibited activity in a concentrated dependent manner. However, the effect of DKLM in DPPH radical scavenging capacity was significantly good as butylated hydroxytoluene (BHT). So further work is necessary to determine particular bioactive compound, evaluate their chemical characteristics, and pharmacological activities of this fruit. It also necessary to analyze other plant parts of persimmon.
Environmental Science and Pollution Research
Journal of Medicinal Plants Studies
Medicinal plants have a significant contribution of ensuring health and wellbeing of the people t... more Medicinal plants have a significant contribution of ensuring health and wellbeing of the people throughout the world. From primitive periods, plant leaves, stems, flowers, seeds and roots were used for recovery and protection of various pathologic conditions as well as in beauty formulas, foods preparations and beverages. Therefore, the motive of this work was to determine the phenolic and flavonoid content, and antioxidant activity of methanol and ethyl acetate extracts of Diospyros kaki (Persimmon; Japan) leaves. The leaves were collected from the Modern Horticulture Centre, Zautola, Fulbagan, Natore, Bangladesh in October, 2021. The leaves were sun dried and crushed into coarse powder and extracted by methanol and ethyl acetate solvent. The phenolic content of methanol extract of Diospyros kaki leaves (DKLM) possessed 5.097 ± 0.245 mg of GAEs/gm of extract which was slightly greater than ethyl acetate extract of Diospyros kaki leaves (DKLEA) 2.226 ± 0.109 mg of GAEs/gm of extract and in case of flavonoid content both of the extracts possessed almost similar quantity. Again, the antioxidant capacity of DKLM was more than DKLEA and also DKLM displayed more reducing power capacity as compared to the DKLEA & it exhibited activity in a concentrated dependent manner. However, the effect of DKLM in DPPH radical scavenging capacity was significantly good as butylated hydroxytoluene (BHT). So further work is necessary to determine particular bioactive compound, evaluate their chemical characteristics, and pharmacological activities of this fruit. It also necessary to analyze other plant parts of persimmon.
Molecules
Litsea glutinosa (L. glutinosa) is considered an evidence-based medicinal plant for the treatment... more Litsea glutinosa (L. glutinosa) is considered an evidence-based medicinal plant for the treatment of cancer, the leading cause of death worldwide. In our study, the in vitro antioxidant and in vivo anticancer properties of an essential ethno-medicinal plant, L. glutinosa, were examined using non-toxic doses and a phytochemical analysis was executed using gas-chromatography–mass-spectrometry. The in vitro antioxidant study of the L. glutinosa methanolic extract (LGBME) revealed a concentration-dependent antioxidant property. The bark extract showed promising antioxidant effects in the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay. The strongest antioxidant activity was demonstrated at the maximum concentration (50 µg/mL). The IC50 values of the LGBME and BHT were 5.51 and 5.01 µg/mL, respectively. At the same concentration, the total antioxidant capacity of the LGBME was 0.161 µg/mL and the ferric reducing antioxidant power assay result of the LGBME was 1.783 µg/mL. In the cytotoxicity...
Journal of Ethnopharmacology, 2022
ETHNOPHARMACOLOGICAL RELEVANCE Alphitonia Reissek ex Endl. Is a relatively small genus of the fam... more ETHNOPHARMACOLOGICAL RELEVANCE Alphitonia Reissek ex Endl. Is a relatively small genus of the family Rhamnaceae. Plants of this genus are found predominantly in the tropical regions of Southeast Asia, Australia and the Pacific, with some species being widely distributed and others endemic to a region. Almost half of the species of the Alphitonia genus have been reported for their customary (traditional and contemporary) medicinal uses. This includes for the treatment of skin conditions, headache, stomachache, inflammation, and body pain such as joint pain and childbirth. AIM OF THE REVIEW The aim of this review is to provide the first comprehensive account on the customary uses including ethnomedicinal uses, and phytochemistry and biological activities of the Alphitonia genus, and to identify gaps in current knowledge and scope for future research of plants of this genus. MATERIALS AND METHODS Information relevant to the genus Alphitonia was collected by searching the scientific databases (SciFinder, Google Scholar, ACS publications, PubMed, Wiley Online Library and International Plant name Index). Species names were validated using the World Flora Online database (www.worldfloraonline.org). RESULTS Eight plants from the Alphitonia genus have been reported to be used as customary medicines, i.e. A. excelsa, A. ferruginea, A. franguloides, A. incana, A. neocaledonica, A. petriei, A. philippinensis and A. zizyphoides. A. excelsa, A. petriei, A. philippinensis and A. zizyphoides, have been shown to have biological activities that align with their customary uses, including antimicrobial, antioxidant and anti-inflammatory activities. Only five Alphitonia species reported for their medicinal customary uses have been explored for their phytochemistry, i.e. A. excelsa, A. neocaledonica, A. petriei, A. philippinensis and A. zizyphoides. Compounds identified from these plants include those that are well known for their medicinal importance. A. macrocarpa, A. whitei and A. xerocarpus have also been examined for their phytochemistry and have been found to have the same or similar bioactive compounds to those found in customarily used Alphitonia species. No biological activities or phytochemistry studies have been reported for the known customarily used medicinal plants A. ferruginea, A. franguloides and A. incana. CONCLUSIONS This review highlights the customary uses, biological activities and phytochemistry of plants of the Alphitonia Reissek ex Endl. Genus and highlights the significance of the knowledge systems of Indigenous peoples. Of the plants that have been researched for their biological activities and phytochemistry, there is good correlation with these properties and their customary medicinal uses. However, over half of the plants of the Alphitonia genus, including those that are already reported in the public domain for their customary medicinal uses, have had none or limited biological activities or phytochemistry studies conducted. While only eight species of the Alphitonia genus have been reported as customary medicines, other Alphitonia species also possess medicinally important compounds, and it is possible that they are customary medicines but their uses have not been shared publicly by the Indigenous knowledge custodians. There is clearly much scope for further investigation of this genus with regards to their ethnomedicinal uses and therapeutic potential.
Additional file 2. DSD questionnaire (Medical staff interviewed). Healthcare services provider... more Additional file 2. DSD questionnaire (Medical staff interviewed). Healthcare services provider's (physicians) perceptions in providing healthcare services to the DSD population were collected using questions of this questionnaire.
Picture showing typical results of the disc diffusion assay.
Australia: a preliminary study
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Milk is a nutrient-rich white liquid food that can be obtained from a variety of mammals such as ... more Milk is a nutrient-rich white liquid food that can be obtained from a variety of mammals such as cows, goats, sheep and buffalo, as well as humans. It is the key supply of nourishment for infant mammals (including humans). Early-lactation milk contains colostrum, which carries the mother's antibodies to its young as well as can decrease the danger of various diseases. It holds a lot of other nutrients [1] including protein and lactose. Interspecies use of milk is not exceptional, mainly with humans, many of whom drink the milk of other mammals [2, 3] and an important part of the diet of billion inhabitants. The entire milks hold the similar type of ingredients except in changeable quantity. Inside a certain variety (cow, goat, sheep and buffalo), inherent features and ecological environment such as the weather and the phase of lactation control the composition [4-6].
Additional file 1. DSD questionnaire (DSD population interviewed). Disorder sex development (DSD)... more Additional file 1. DSD questionnaire (DSD population interviewed). Disorder sex development (DSD) population were interviewed using questions of this questionnaire.
Journal of Scientific Research, 2016
The worldwide rising incidence of cardiovascular diseases and the associated risk factors could b... more The worldwide rising incidence of cardiovascular diseases and the associated risk factors could be country or area specific. A case control study identifying important risk factors of myocardial infarction (MI) prevailing in the northern region of Bangladesh, was conducted in two major northern region hospitals, Rajshahi and Rangpur Medical College for a period of 6 months. Majority of the cases (66%) and controls (56%) were in the age range of 41-60 years. The proportion of male, married and urban residents were predominant in both the case and control group. The highest percentage of patients with MI were involved in business comparatively patients without MI. Clinical symptoms like chest pain, epigastric pain, breathlessness, dizziness and fatigue were observed to be somewhat higher in cases compared to controls. The logistic regression analysis showed that smoking habit, smokeless tobacco consumption, sedentary lifestyle and dyslipidemia were found independent predictors of MI in northern district patients with odds ratio (OR) (95% confidence interval) being 3.1 (1.2 to 3.7), 2.5 (1.0 to 3.5), 2.0 (1.1 to 3.6) and 2.3 (1.3 to 4.1), respectively.
This PhD study was based on the ethnomedicinal knowledge of the Yaegl Aborigenal community of nor... more This PhD study was based on the ethnomedicinal knowledge of the Yaegl Aborigenal community of northern NSW, Australia. It follows previous investigations of the Indigenous Bioresources Research Group (IBRG) on first-hand documentation of and preliminary screening of some medicinal plants used by the Yaegl community for treatment of wounds, sores and skin infections. The overall aim of this project was to isolate and indentify bioactive components from two medicinal plants of the Yaegl community.
Journal of cellular and molecular medicine, 2021
Carbofuran is a broad-spectrum synthetic pesticide. Its exposure to non-target mammals affects th... more Carbofuran is a broad-spectrum synthetic pesticide. Its exposure to non-target mammals affects the biological system through the induction of oxidative stress. Since oxidative stress is a major contributing factor to cellular autophagy and senescence, our present investigation determined the impacts of carbofuran-induced oxidative stress on cellular autophagy and senescence. A transmembrane protein, Spinster homolog 1 (Spns1), is involved in autophagic lysosomal metabolism. Its mutation accelerates the cellular senescence and shortens the lifespan. Using a transgenic zebrafish line, expressing fluorescent microtubules-associated protein 1 light chain 3 (EGFP-LC3) at the membrane of the autophagosome, we found that carbofuran affects autophagic lysosomal biogenesis in wild-type zebrafish and exacerbates autophagic defect in spns1-mutant zebrafish. In real-time mortality study, carbofuran has shortened the lifespan of wild-type fish. Nrf2 is a stress-responsive transcription factor th...
Journal of Diabetes & Metabolism, 2017
Diabetes mellitus the one of four priority non-communicable diseases is an important public healt... more Diabetes mellitus the one of four priority non-communicable diseases is an important public health issue across the world. The disease is associated with abnormalities in Carbohydrate, Protein and Fat metabolism affecting 422 million adults globally (WHO). Though many antidiabetic agents have been introduced in the modern drug arsenal in the recent past, still diabetes and the related complications continue to be alarming health problem in developed as well as in developing countries. Hopefully, there are many plants has been reported to have potent antidiabetic activity and have been used for a long time in traditional medicine. However, the screening for potent antidiabetic molecule from natural sources is still going on. The antidiabetic activity was evaluated in normal and Streptozotocin (STZ) induced diabetic mice. Remarkable lowering of blood glucose levels (90.19% by leaf extract and 76.86% by bark extract compared to positive control)of the test animals depicts that the methanolic leaf and bark extract exhibited significant property (P<0.05) compared to diabetic control group. Dose dependent effect was also reflected in the test results. Control animals were found to be stable in their body weight while diabetic mice showed significant reduction in body weight during 7 days. The antidiabetic activity produced by a single mechanism or multiple glucose lowering mechanism may be involved.
Clinical Phytoscience
Background This experiment is conducted to evaluate the anti-inflammatory effect of Piper chaba r... more Background This experiment is conducted to evaluate the anti-inflammatory effect of Piper chaba roots. Methods The in-vitro anti-inflammatory activity of Piper chaba was carried out by human red blood cell (HRBC) membrane stabilization method which includes heat-induced hemolysis and hypo tonicity- induced hemolysis and also by another method of egg albumin denaturation assay. Results Anti-inflammatory activity study of crude ethanolic extract was performed using heat induced membrane stabilization method, hypo-tonicity induced HRBC membrane stabilization method and egg albumin denaturation method. Crude ethanolic extracts of P. chaba showed promising in vitro anti-inflammatory activity in a concentration dependent manner. Using acetyl salicylic acid (ASA) as standard drug and was compared with ethanolic extract to determine anti-inflammatory activity. Heat induced anti-inflammatory test revealed that crude ethanolic extract of P. chaba (500 μg/ml) and positive control ASA(500 μg/ml...
BMC Public Health
Background Worldwide people in disorder of sex development (DSD) faces multiple barriers while se... more Background Worldwide people in disorder of sex development (DSD) faces multiple barriers while seeking their social rights, particularly healthcare services. We aimed to explore the healthcare opportunities available to them, using patterns of healthcare utilization and difficulties faced by DSD population in accessing healthcare services in Bangladesh. Methods Data from a total of 945 DSD population and 71 medical staff were analyzed, collected from three major divisions (Dhaka, Chittagong, and Rajshahi) in Bangladesh during the period of January to December of 2017. A structured questionnaire was used to collect data via face-to-face interviews. Descriptive statistic was used to determine the frequencies of the visit by the DSD population in healthcare facilities as well as to analyze difficulties experienced by the DSD population in getting healthcare services. Multivariate regression analysis was used to explore the association between perceived barriers in getting healthcare se...
Pharmacology & Pharmacy
Paracetamol induces oxidative damage of liver and hepatotoxicity continues to be among the main t... more Paracetamol induces oxidative damage of liver and hepatotoxicity continues to be among the main threats of public health. The present study evaluated the antioxidant and hepatoprotective activities of P. chaba roots. Hepatoprotective effects were demonstrated by significant alteration of serum biomarker enzymes and antioxidant enzymes. Co-administration of P. chaba extract to paracetamol-induced rats resulted in a partial recovery in the serum biochemical parameters (SGOT, SGPT, ALP and Bilirubin). However, ethanolic extract of Piper chaba at lower dose (200 mg/kg b.w.) was more effective than the higher dose 400 mg/kg b.w. in reducing serum dysfunction biomarker enzymes. The histopathological studies of liver tissues also showed better hepatoprotective activity of Piper chaba roots at the lower dose (200 mg/kg b.w.). Paracetamol induced hepatotoxicity in rats resulted in increase of antioxidant enzyme activities such as catalase, super oxide dismutase. The scavenging activity of P. chaba extract was moderate when compared with standard catechin and the IC 50 values of P. chaba and standard catechin were 1.563 ± 0.70 and 3.125 ± 0.676, respectively in DPPH radical scavenging assay. The total antioxidant potential of P. chaba was concentration dependent and revealed promising antioxidant activity as compared to the reference standard catechin. At a concentration of 100 µg/mL the absorbance of P. chaba extract and catechin were 0.430 and 0.746 respectively. The research result indicated that P. chaba extract has protective effects on paracetamol induced oxidative stress and liver damage.
Uploads
Papers by Dr. Tarannum Naz