balsamifera L) dan 13. Jamur ((Ganoderma lucidum).). Ada dua jenis obat yang sudah diproduksi Pra... more balsamifera L) dan 13. Jamur ((Ganoderma lucidum).). Ada dua jenis obat yang sudah diproduksi Prajuru Pura Tamba Waras yaitu Obat Minum dan Obat Urut
Experiments were performed to determine the effect of allelochemicals released by weed clipping o... more Experiments were performed to determine the effect of allelochemicals released by weed clipping on the growth of vanilla cuttings. The objective of these experiments was to find out safe plant material for mulching vanilla plantation. The first experiment was conducted in the wet season, where two nodes cuttings were transplanted into 5 groups of pots containing topsoil and mulched with grass (G), fern (F), taro (T), dry leaf (DL) and without mulch as control cuttings (C). The second experiment was under dry season but using a similar procedure like that in the first experiment except dry leaf was replaced with coconut husk (CH). These two experiments were using 8 replicates and grown in a shaded greenhouse. Phenolic compounds in weed clippings were examined using the Folin-Ciocalteu method. This study found that fern and taro clipping decreased soil pH, delayed emergence of new root and bud burst in vanilla cutting. By contrast, grass clipping, dry leaf and coconut husk did not decrease soil pH and did not delay root emergence and bud burst. The growth rate of the new stem in grass added plant was 1.4 folds relative control but only 0.4 fold in taro added plants. It is concluded that vanilla plant resistant to phenolic compound released by grass clipping, but susceptible to phenolic compound released by taro clipping.
Biopharmaca is a biological preparation that comes from nature that has properties as a medicine.... more Biopharmaca is a biological preparation that comes from nature that has properties as a medicine. Biopharmaca products are categorized into three types, namely herbal medicine, standardized herbal medicine (OHT), and phytopharmaca. The research objective is to find out the benefits of biopharmaca products in leading a healthy Indonesia. Qualitative descriptive research with the method of collecting data is observation and recording documents. The results show that the benefits of biopharmaca products can improve health in the community, are more effective, more affordable, and have relatively smaller side effects. The use of biopharmaca products has global competitiveness that is utilized by residents of several countries such as: China (People’s Republic of China) reaching 90%, Chile reaching 71%, Colombia reaching 40%, France reaching 49%, Canada reaching 78%, Britain reaching 60%, The United States reached 42%, and Germany reached 73%. In moving towards a healthy Indonesia, bioph...
Aloe vera (Aloe barbadensis Miller) contains anthraquinone compounds, flavonoids and saponins whi... more Aloe vera (Aloe barbadensis Miller) contains anthraquinone compounds, flavonoids and saponins which are thought to have antibacterial effects so as to inhibit bacterial growth. The purpose of the study was to determine the inhibitory power of Aloe barbadensis Miller on the growth of Staphylococcus aureus bacteria. The pure experimental study was conducted with The Randomized Posttest Only Control Group Design using six (6) treatments, namely aloe vera extract with a concentration of 25%, 50%, 75%, 100%, Chloramphenicol 30 mcg antibiotics as a positive control, and sterile aquadest as a control negative for Staphylococcus aureus bacteria grown on Mueller Hinton media. After being treated, it was incubated for 24 hours and measured its inhibitory power. The growth inhibition data of Staphylococcus aureus bacteria in the form of inhibition zone diameter was analyzed statistically by Kruskal Wallis test, at the level of confidence α = 0.05. The results showed that the average inhibitory...
Apabila ada kritik dan saran, mohon menyampaikan kritik & saran untuk Kementerian Pendidikan dan ... more Apabila ada kritik dan saran, mohon menyampaikan kritik & saran untuk Kementerian Pendidikan dan Kebudayaan terkait upaya untuk melancarkan implementasi kebijakan Merdeka Belajar-Kampus Merdeka? Kembali Selanjutnya Perlu dilakukan sosialisasi secara langsung kepada para dosen dan Program Studi melaui workshop SURVEI MERDEKA BELAJAR-KAMPUS MERDEKA (MBKM) Terimakasih atas partisipasi Saudara dalam mengisi survei ini. Partisipasi dan kontribusi saudara, akan menjadi dasar strategi implementasi MBKM tahun depan.
The rhizome of the bangle contains antibacterial compounds including saponins, flavonoids, essent... more The rhizome of the bangle contains antibacterial compounds including saponins, flavonoids, essential oils, and tannins. The aim of the study was to determine the inhibitory power of bangle rhizome extract on the growth of Staphylococcus aureus bacteria. True research - experiment with posttest design with control group was carried out by giving 6 treatment groups, namely negative control group (K-) using aquadest, positive control group (K +) using 30 mcg Chloramphenicol antibiotics, 25% ( PE1), 50% (PE2), 75% (PE3), and 100% (PE4) of concentration of rhizome extract treatment. After the treatment is complete, the inhibition is measured. The research data were analyzed statistically by Kruskall Wallis non parametric test and Sperman Rang correlation test. The results showed that the average inhibition of bangle rhizomes in each group in groups K-, K+, PE1, PE2, PE3, and PE4 were 0.000 ± 0.000, 25.000 ± 0.408, 14.250 ± 0.479, 16.500 ± 0.289, 17.750 ± 0.250, 19,500 ± 0.289 differ sign...
Logam timbal (Pb) sebagai sisa hasil pembakaran bahan bakar fosil kendaraan bermotor merupakan pe... more Logam timbal (Pb) sebagai sisa hasil pembakaran bahan bakar fosil kendaraan bermotor merupakan penyebab utama pencemaran lingkungan udara. Daun trembesi sebagai tanaman peneduh jalan berfungsi sebagai bioindicator pencemaran udara oleh logam Pb. Tujuan penelitian adalah untuk menentukan kandungan logam Pb dan perbedaan kandungannya pada daun trembesi yang berada disebelah Utara dan Selatan Jalan Prof. Dr. Ida Bagus Mantra. Penelitian dilakukan dengan mengambil sampel daun trembesi di lima wilayah (klaster) yang masing-masing berjarak 4 km baik di sebelah Utara maupun Selatan Jalan Prof. Dr Ida Bagus Mantra. Penentuan kandungan logam Pb pada daun trembesi dilakukan dengan metode AAS. Data kandungan logam Pb pada daun trembesi dianalisis secara statistk dengan dengan uji beda Mann Whitney µ pada taraf signifikansi ? = 0,05. Dari hasil penelitian dapat disimpulkan bahwa kandungan rata-rata logam Pb pada daun trembesi yang berada disebelah Utara dan Selatan Jalan Prof. Dr. Ida ba...
Loloh air rebusan daun sirih merupakan obat tradisional Bali mengandung senyawa aktif Hidroksicha... more Loloh air rebusan daun sirih merupakan obat tradisional Bali mengandung senyawa aktif Hidroksichavikol, memiliki aktivitas sebagai antioksidan dan antidislipemia. Dari hasil-hasil penelitian dilaporkan bahwa loloh air rebusan daun sirih mengandung senyawa aktif hidroksikavikol (HC). Senyawa aktif hiroksikavikol memiliki aktivitas sebagai antioksidan dan antidislipidemia. Sebagai anti oksidan dapat mengais ROS dan menghambat aktivitas radikal bebas. Sebagai antidislipidemia dapat menormalkan metabolisma lipid dengan menurunkan kadar kolesterol total, trigliserida, LDL dan VLDL serta meningkatkan kadar HDL serum darah. Stres oksidatif dan dislipidemia merupakan factor resiko utama penyakit jantung yang disebabkan oleh aterosklerosis. Aterosklerosis adalah terjadinya pembentukkan plak di dalam lumen pembuluh darah yang dipicu oleh sters oksidatif melalui disfungsi sel endotel, implamasi dan peroksidasi lipid. Stres oksidatif menyebabkan disfunsi sel endotel, meningkatkan kontraktilitas...
Pestisida sintetis yang digunakan dalam pengendalian organisme pengganggu tanaman (OPT) menimbulk... more Pestisida sintetis yang digunakan dalam pengendalian organisme pengganggu tanaman (OPT) menimbulkan masalah terkait pencemaran lingkungan, kesehatan, terganggunya musuh alami bukan sasaran, resiko pada pengguna dan konsumen serta masalah negatif lainnya. Oleh karena itu perlu dicari alternatif insektisida berbahan baku alami dari tanaman yang berpotensi sebagai pestisida. Brotowali (Tinospora crispa L. Miers) banyak tumbuh di Jawa, Bali dan Maluku, merupakan tanaman berkhasiat obat, antijamur, antibakteri, antinemasida anti antimoluska. Hasil penelitian ekstrak daun brotowali pada konsentrasi 1% dapat menekan aktivitas makan potongan daun kubis secara in vitro sebesar 44,29% dan mortalitas larva Plutella xylostella sebesar 13,33%. Korelasi nyata (r2 = 0,9585) terjadi antara konsentrasi ekstrak daun brotowali dengan penurunan aktivitas makan larva P. xylostella. Hasil fraksinasi ekstrak daun brotowali dari beberapa pelarut didapat 14 kelompok senyawa (fraksi). Fraksi V dengan pelarut...
Kadar asam urat yang tinggi merupakan faktor etiologi utama dari gout dan patofisiologi jaringan ... more Kadar asam urat yang tinggi merupakan faktor etiologi utama dari gout dan patofisiologi jaringan pembuluh darah. Beberapa penelitian menjelaskan bahwa asam urat dapat menginduksi inflamasi dengan aktivasi sistem imun dan mengubah karakteristik VSMC dan sel endotel, untuk memberi kecenderungan terjadinya proliferasi VSCM dan disfunsi sel endotel (ECD). Asam urat berperan sebagai sinyal berbahaya yang dapat memicu aktivasi NLRP3-implamasom dengan merangsang Toll-like receptor jalur 2/4-Myd88 selanjutnya diaktifkan oleh pathogen-associated molecular patterns (PAMPs) atau damage-associated molecular patterns (DAMPs) untuk membentuk IL-1 dan IL-18 sebagai sitokin proinflamasi melalui jalur aktivasi NF-KB. IL-1 melalui reseptornya (IL-1R) pada sel, dan bersama dengan faktor kemotaktik lain, berfungsi sebagai sinyal untuk menarik neutrofil dan sel-sel imun lainnya, sehingga memunculkan respon inflamasi. Konsentrasi asam urat yang tinggi menginduksi proliferasi VSMC dengan penyerapan kedala...
Majegau plants are widely used for various needs, including for medicinal ingredients, cultural a... more Majegau plants are widely used for various needs, including for medicinal ingredients, cultural and traditional rituals, so that their existence in nature becomes scarce. To prevent its extinction, it is necessary to preserve, especially the forests on the island of Bali. The preservation of majegau plants as ceremonial plants and medicinal plants in the Pura Batukau area, was carried out using the method of labeling majegau plants and counseling for parejura pura. Majegau plants as ceremonial plants, especially in Bali, are widely used as sacred building materials (temples), as ceremonial firewood (pasepan) and are used in manusa yadnya ceremonies because they are believed to have their stems symbolizing Bhatara Sadasiwa. Majegau plants as medicinal plants are used as ingredients in traditional medicine, namely sap, roots to leaves mixed with vinegar, charcoal salt for herbal medicine is used to treat nausea without vomiting. Besides, it is also traditionally used to treat skin irr...
Penyakit virus corona (COVID-19) yang disebabkan oleh virus corona 2 sindrum pernapasan akut bera... more Penyakit virus corona (COVID-19) yang disebabkan oleh virus corona 2 sindrum pernapasan akut berat (SARS-CoV-2) awalnya di mulai di Wuhan Cina pada Desember 2019, menyebar keseluruh dunia dan mempengaruhi lebih dari 180 negara. Sebagai kasus yang menyebar secara global telah dicatat bahwa orang-orang dengan penyakit kronis yang mendasar yang sudah ada sebelumnya lebih memungkinkan untuk terserang virus dan menjadi lebih parah. Pasien COVID-19 dengan riwayat penyakit penyerta memiliki prognosis penyakit yang parah dengan peningkatan risiko kematian yang semakin tinggi. Komorbiditas (penyakit penyerta) COVID-19 yang sudah ada sebelumnya dan paling umum adalah hipertensi, diabetes, dan penyakit kardiovaskular. Sirih merupakan tanamam obat yang sudah dikenal selama berabad-abad, daunnya banyak digunakan sebagai bahan obat tradisional untuk mengobati berbagai macam penyakit mengndung senyawa bioaktif seperti polifenol, alkaloid, steroid, saponin, dan tannin, memiliki aktivitas farmakolog...
This research aims to use tubers into tape products as a substitution for rice in the application... more This research aims to use tubers into tape products as a substitution for rice in the application of fermented biotechnological learning. The research used a type of local tubers such as sweet potato, which includes purple sweet potato (purple color), honey sweet potato (yellow color), white sweet potato (white color) and taro (Colocasia esculenta (L.) Schott.), while the control treatment used cassava (Manihot utillisima Crantz) using completely randomized research design. The tests were conducted by looking for the alcohol content and through organoleptic test (taste) as well as the appearance of the tape products by involving 20 researchers as testers. The results showed that the making of tape using tubers through fermentation process produced an average alcohol of 3.994% in honey sweet potatoes; 1.3773% in white sweet potato; 1.0576% in purple sweet potato; 1.3295% in taro and 0.59625% in cassava. The organoleptic test conducted by the panelists showed: honey sweet potato (yell...
ECOTROPHIC : Jurnal Ilmu Lingkungan (Journal of Environmental Science), 2020
This research objective examined the source of pollutants, water quality and water pollution leve... more This research objective examined the source of pollutants, water quality and water pollution level of Buyan Lake. The research conducted field observation to identify the source of pollutants, measuring the water quality and water pollution level of Lake Buyan compared to the standard of environmental quality and damage criteria. This research employed the newest standard measurement and equipment in purpose of water and wastewater inspection. Furthermore, this research used STORET method to analys the pollution level. The results discovered that the pollutant’s source was the settlement and agricultural activities around Buyan Lake. The average value of physical parameters i.e temperature, dissolved residue (TDS), suspended residue (TSS), turbidity and brightness are 23.02 oC; 127 mg.L-1, 4.71 mg L-1, 12.52 JTU; and 133.6 cm respectively. The average values ??of the chemical parameters i.e. pH, DO, BOD5, COD, NO3, NO2, Ammonia and Phosphate are 7.48, 5.95 mg.L-1*, 25.46 mg.L-1*, 42...
Hiperurisemia sudah dikenal sejak dahulu, dan mendapat perhatian medis karena berhubungan dengan ... more Hiperurisemia sudah dikenal sejak dahulu, dan mendapat perhatian medis karena berhubungan dengan berbagai penyakit seperti tekanan darah tinggi, aterosklerosis, penyakit ginjal, diabetes melitus dan penyakit kardiovaskular. Hubungan ini mungkin memiliki penyebab yang signifikan namun, tidak ada mekanisma yang jelas hiperurisemia menyebabkan penyakit kardiovaskular. Hiperurisemia sebagai faktor risiko penyakit kardiovaskular dengan memberikan efek vaskular secara langsung dan menyebabkan kerusakan vaskular. Berdasarkan hasil-hasil penelitian diketahui bahwa Asam urat menyebabkan proliferasi endotel, produksi angiotensin II dan peningkatan stres oksidatif (ROS). Asam urat pada konsentrasi tinggi (hiperurisemia) menimbulkan stress oksidatif dengan meningkatkan pembentukan ROS, menginduksi perubahan vaskular melalui aktivasi jalur sinyal sensitif redoks mengaktifkan mitogen activated protein kinase (MAPKs), tirosin kinase dan faktor transkripsi (NFKB, AP-1, dan HIF-1) merangsang Volume ...
Sore throat is a respiratory infection caused by a bacterial infection of Streptococcus pyogenes.... more Sore throat is a respiratory infection caused by a bacterial infection of Streptococcus pyogenes. Betel leaf is used for loloh (traditional medicine) which has antimicrobial activity. The purpose of this study was to determine the content of active compounds and the antibacterial activity of the boiled water and juice of betel leaf against Streptococcus pyogenes. Explorative research using GC-MS method was used to identify and determine the abundance (content) of active compounds from loloh while the experimental research with the Randomized Post Test Only Control Group Design was carried out by treating the samples in four groups those are the negative control group with distilled water, the positive control group with 30 μg vancomycin, the treatment group with boiled water of betel leaf and betel leaf juice water to prove the antibacterial activity of loloh. The antibacterial activity data of the study results were analyzed statistically nonparametric through the Kruskal-Wallis te...
Background: Betel leaf extracts (Piper betle L.) antioxidant activity and enzyme inhibitors of XO... more Background: Betel leaf extracts (Piper betle L.) antioxidant activity and enzyme inhibitors of XO. Hyperuricemia cause oxidative stress by increasing the formation of reactive oxygen species (ROS) cause lipid peroxidation and oxygenation of low-density lipoprotein cholesterol (LDLc). Objective: The aim of this research was to determine the betel leaf extract as an anti hyperuricemia that can lower the blood uric acid levels and oxidative stress by lowering the levels of MDA and increase the SOD of hyperuricemia of the rat's blood. Method: Experimental research was conducted with the design of The Randomized Post Test Only Control Group Design, on normal Wistar rats (Rattus norvegicus), administered with oxonic potassium (hyperuricemia) and the hyperuricemia rats either given betel leaf extract and allopurinol. After the experiment of uric acid levels, MDA and SOD in rat blood determined. Results: The results showed that the betel leaf extract significantly (p <0.05) lower uric acid levels, MDA and increase levels of SOD in rat blood. There is a positive correlation between the levels of uric acid with MDA levels and a negative correlation, although not significantly with SOD (p >0.05). Conclusion: It can be concluded that the betel leaf extract as an anti-hyperuricemia can lower the uric acid levels and decreases oxidative stress by lowering the levels of MDA and increasing the SOD.
Clinical manifestations of dengue virus infection vary from unspecified fever, dengue fever (DF) ... more Clinical manifestations of dengue virus infection vary from unspecified fever, dengue fever (DF) and dengue hemorrhagic fever (DHF). The fundamental difference in the diagnosis between DF and DHF is plasma leakage, hypotension, thrombocytopenia and hemorrhagic diathesis in DHF. The objectives of the study were to determine the lowest platelet, haematocrit increase, and TNF-α levels in DF and DHF patients as an indication of severity of dengue virus infection. The cross-sectional study was conducted by taking 54 blood samples of patients aged 26-45 years who were infected by dengue virus and grouped into two groups: DF patient group (27 blood samples) and DHF group (27 blood samples). The lowest platelets and hematocrit rise were determined by Hematology Analyzer and the TNF-α levels were determined by ELISA. The data obtained were statistically analyzed by independent Mann-Whitney test. The results showed that the lowest mean platelet counts of DF patients were significantly (p <...
balsamifera L) dan 13. Jamur ((Ganoderma lucidum).). Ada dua jenis obat yang sudah diproduksi Pra... more balsamifera L) dan 13. Jamur ((Ganoderma lucidum).). Ada dua jenis obat yang sudah diproduksi Prajuru Pura Tamba Waras yaitu Obat Minum dan Obat Urut
Experiments were performed to determine the effect of allelochemicals released by weed clipping o... more Experiments were performed to determine the effect of allelochemicals released by weed clipping on the growth of vanilla cuttings. The objective of these experiments was to find out safe plant material for mulching vanilla plantation. The first experiment was conducted in the wet season, where two nodes cuttings were transplanted into 5 groups of pots containing topsoil and mulched with grass (G), fern (F), taro (T), dry leaf (DL) and without mulch as control cuttings (C). The second experiment was under dry season but using a similar procedure like that in the first experiment except dry leaf was replaced with coconut husk (CH). These two experiments were using 8 replicates and grown in a shaded greenhouse. Phenolic compounds in weed clippings were examined using the Folin-Ciocalteu method. This study found that fern and taro clipping decreased soil pH, delayed emergence of new root and bud burst in vanilla cutting. By contrast, grass clipping, dry leaf and coconut husk did not decrease soil pH and did not delay root emergence and bud burst. The growth rate of the new stem in grass added plant was 1.4 folds relative control but only 0.4 fold in taro added plants. It is concluded that vanilla plant resistant to phenolic compound released by grass clipping, but susceptible to phenolic compound released by taro clipping.
Biopharmaca is a biological preparation that comes from nature that has properties as a medicine.... more Biopharmaca is a biological preparation that comes from nature that has properties as a medicine. Biopharmaca products are categorized into three types, namely herbal medicine, standardized herbal medicine (OHT), and phytopharmaca. The research objective is to find out the benefits of biopharmaca products in leading a healthy Indonesia. Qualitative descriptive research with the method of collecting data is observation and recording documents. The results show that the benefits of biopharmaca products can improve health in the community, are more effective, more affordable, and have relatively smaller side effects. The use of biopharmaca products has global competitiveness that is utilized by residents of several countries such as: China (People’s Republic of China) reaching 90%, Chile reaching 71%, Colombia reaching 40%, France reaching 49%, Canada reaching 78%, Britain reaching 60%, The United States reached 42%, and Germany reached 73%. In moving towards a healthy Indonesia, bioph...
Aloe vera (Aloe barbadensis Miller) contains anthraquinone compounds, flavonoids and saponins whi... more Aloe vera (Aloe barbadensis Miller) contains anthraquinone compounds, flavonoids and saponins which are thought to have antibacterial effects so as to inhibit bacterial growth. The purpose of the study was to determine the inhibitory power of Aloe barbadensis Miller on the growth of Staphylococcus aureus bacteria. The pure experimental study was conducted with The Randomized Posttest Only Control Group Design using six (6) treatments, namely aloe vera extract with a concentration of 25%, 50%, 75%, 100%, Chloramphenicol 30 mcg antibiotics as a positive control, and sterile aquadest as a control negative for Staphylococcus aureus bacteria grown on Mueller Hinton media. After being treated, it was incubated for 24 hours and measured its inhibitory power. The growth inhibition data of Staphylococcus aureus bacteria in the form of inhibition zone diameter was analyzed statistically by Kruskal Wallis test, at the level of confidence α = 0.05. The results showed that the average inhibitory...
Apabila ada kritik dan saran, mohon menyampaikan kritik & saran untuk Kementerian Pendidikan dan ... more Apabila ada kritik dan saran, mohon menyampaikan kritik & saran untuk Kementerian Pendidikan dan Kebudayaan terkait upaya untuk melancarkan implementasi kebijakan Merdeka Belajar-Kampus Merdeka? Kembali Selanjutnya Perlu dilakukan sosialisasi secara langsung kepada para dosen dan Program Studi melaui workshop SURVEI MERDEKA BELAJAR-KAMPUS MERDEKA (MBKM) Terimakasih atas partisipasi Saudara dalam mengisi survei ini. Partisipasi dan kontribusi saudara, akan menjadi dasar strategi implementasi MBKM tahun depan.
The rhizome of the bangle contains antibacterial compounds including saponins, flavonoids, essent... more The rhizome of the bangle contains antibacterial compounds including saponins, flavonoids, essential oils, and tannins. The aim of the study was to determine the inhibitory power of bangle rhizome extract on the growth of Staphylococcus aureus bacteria. True research - experiment with posttest design with control group was carried out by giving 6 treatment groups, namely negative control group (K-) using aquadest, positive control group (K +) using 30 mcg Chloramphenicol antibiotics, 25% ( PE1), 50% (PE2), 75% (PE3), and 100% (PE4) of concentration of rhizome extract treatment. After the treatment is complete, the inhibition is measured. The research data were analyzed statistically by Kruskall Wallis non parametric test and Sperman Rang correlation test. The results showed that the average inhibition of bangle rhizomes in each group in groups K-, K+, PE1, PE2, PE3, and PE4 were 0.000 ± 0.000, 25.000 ± 0.408, 14.250 ± 0.479, 16.500 ± 0.289, 17.750 ± 0.250, 19,500 ± 0.289 differ sign...
Logam timbal (Pb) sebagai sisa hasil pembakaran bahan bakar fosil kendaraan bermotor merupakan pe... more Logam timbal (Pb) sebagai sisa hasil pembakaran bahan bakar fosil kendaraan bermotor merupakan penyebab utama pencemaran lingkungan udara. Daun trembesi sebagai tanaman peneduh jalan berfungsi sebagai bioindicator pencemaran udara oleh logam Pb. Tujuan penelitian adalah untuk menentukan kandungan logam Pb dan perbedaan kandungannya pada daun trembesi yang berada disebelah Utara dan Selatan Jalan Prof. Dr. Ida Bagus Mantra. Penelitian dilakukan dengan mengambil sampel daun trembesi di lima wilayah (klaster) yang masing-masing berjarak 4 km baik di sebelah Utara maupun Selatan Jalan Prof. Dr Ida Bagus Mantra. Penentuan kandungan logam Pb pada daun trembesi dilakukan dengan metode AAS. Data kandungan logam Pb pada daun trembesi dianalisis secara statistk dengan dengan uji beda Mann Whitney µ pada taraf signifikansi ? = 0,05. Dari hasil penelitian dapat disimpulkan bahwa kandungan rata-rata logam Pb pada daun trembesi yang berada disebelah Utara dan Selatan Jalan Prof. Dr. Ida ba...
Loloh air rebusan daun sirih merupakan obat tradisional Bali mengandung senyawa aktif Hidroksicha... more Loloh air rebusan daun sirih merupakan obat tradisional Bali mengandung senyawa aktif Hidroksichavikol, memiliki aktivitas sebagai antioksidan dan antidislipemia. Dari hasil-hasil penelitian dilaporkan bahwa loloh air rebusan daun sirih mengandung senyawa aktif hidroksikavikol (HC). Senyawa aktif hiroksikavikol memiliki aktivitas sebagai antioksidan dan antidislipidemia. Sebagai anti oksidan dapat mengais ROS dan menghambat aktivitas radikal bebas. Sebagai antidislipidemia dapat menormalkan metabolisma lipid dengan menurunkan kadar kolesterol total, trigliserida, LDL dan VLDL serta meningkatkan kadar HDL serum darah. Stres oksidatif dan dislipidemia merupakan factor resiko utama penyakit jantung yang disebabkan oleh aterosklerosis. Aterosklerosis adalah terjadinya pembentukkan plak di dalam lumen pembuluh darah yang dipicu oleh sters oksidatif melalui disfungsi sel endotel, implamasi dan peroksidasi lipid. Stres oksidatif menyebabkan disfunsi sel endotel, meningkatkan kontraktilitas...
Pestisida sintetis yang digunakan dalam pengendalian organisme pengganggu tanaman (OPT) menimbulk... more Pestisida sintetis yang digunakan dalam pengendalian organisme pengganggu tanaman (OPT) menimbulkan masalah terkait pencemaran lingkungan, kesehatan, terganggunya musuh alami bukan sasaran, resiko pada pengguna dan konsumen serta masalah negatif lainnya. Oleh karena itu perlu dicari alternatif insektisida berbahan baku alami dari tanaman yang berpotensi sebagai pestisida. Brotowali (Tinospora crispa L. Miers) banyak tumbuh di Jawa, Bali dan Maluku, merupakan tanaman berkhasiat obat, antijamur, antibakteri, antinemasida anti antimoluska. Hasil penelitian ekstrak daun brotowali pada konsentrasi 1% dapat menekan aktivitas makan potongan daun kubis secara in vitro sebesar 44,29% dan mortalitas larva Plutella xylostella sebesar 13,33%. Korelasi nyata (r2 = 0,9585) terjadi antara konsentrasi ekstrak daun brotowali dengan penurunan aktivitas makan larva P. xylostella. Hasil fraksinasi ekstrak daun brotowali dari beberapa pelarut didapat 14 kelompok senyawa (fraksi). Fraksi V dengan pelarut...
Kadar asam urat yang tinggi merupakan faktor etiologi utama dari gout dan patofisiologi jaringan ... more Kadar asam urat yang tinggi merupakan faktor etiologi utama dari gout dan patofisiologi jaringan pembuluh darah. Beberapa penelitian menjelaskan bahwa asam urat dapat menginduksi inflamasi dengan aktivasi sistem imun dan mengubah karakteristik VSMC dan sel endotel, untuk memberi kecenderungan terjadinya proliferasi VSCM dan disfunsi sel endotel (ECD). Asam urat berperan sebagai sinyal berbahaya yang dapat memicu aktivasi NLRP3-implamasom dengan merangsang Toll-like receptor jalur 2/4-Myd88 selanjutnya diaktifkan oleh pathogen-associated molecular patterns (PAMPs) atau damage-associated molecular patterns (DAMPs) untuk membentuk IL-1 dan IL-18 sebagai sitokin proinflamasi melalui jalur aktivasi NF-KB. IL-1 melalui reseptornya (IL-1R) pada sel, dan bersama dengan faktor kemotaktik lain, berfungsi sebagai sinyal untuk menarik neutrofil dan sel-sel imun lainnya, sehingga memunculkan respon inflamasi. Konsentrasi asam urat yang tinggi menginduksi proliferasi VSMC dengan penyerapan kedala...
Majegau plants are widely used for various needs, including for medicinal ingredients, cultural a... more Majegau plants are widely used for various needs, including for medicinal ingredients, cultural and traditional rituals, so that their existence in nature becomes scarce. To prevent its extinction, it is necessary to preserve, especially the forests on the island of Bali. The preservation of majegau plants as ceremonial plants and medicinal plants in the Pura Batukau area, was carried out using the method of labeling majegau plants and counseling for parejura pura. Majegau plants as ceremonial plants, especially in Bali, are widely used as sacred building materials (temples), as ceremonial firewood (pasepan) and are used in manusa yadnya ceremonies because they are believed to have their stems symbolizing Bhatara Sadasiwa. Majegau plants as medicinal plants are used as ingredients in traditional medicine, namely sap, roots to leaves mixed with vinegar, charcoal salt for herbal medicine is used to treat nausea without vomiting. Besides, it is also traditionally used to treat skin irr...
Penyakit virus corona (COVID-19) yang disebabkan oleh virus corona 2 sindrum pernapasan akut bera... more Penyakit virus corona (COVID-19) yang disebabkan oleh virus corona 2 sindrum pernapasan akut berat (SARS-CoV-2) awalnya di mulai di Wuhan Cina pada Desember 2019, menyebar keseluruh dunia dan mempengaruhi lebih dari 180 negara. Sebagai kasus yang menyebar secara global telah dicatat bahwa orang-orang dengan penyakit kronis yang mendasar yang sudah ada sebelumnya lebih memungkinkan untuk terserang virus dan menjadi lebih parah. Pasien COVID-19 dengan riwayat penyakit penyerta memiliki prognosis penyakit yang parah dengan peningkatan risiko kematian yang semakin tinggi. Komorbiditas (penyakit penyerta) COVID-19 yang sudah ada sebelumnya dan paling umum adalah hipertensi, diabetes, dan penyakit kardiovaskular. Sirih merupakan tanamam obat yang sudah dikenal selama berabad-abad, daunnya banyak digunakan sebagai bahan obat tradisional untuk mengobati berbagai macam penyakit mengndung senyawa bioaktif seperti polifenol, alkaloid, steroid, saponin, dan tannin, memiliki aktivitas farmakolog...
This research aims to use tubers into tape products as a substitution for rice in the application... more This research aims to use tubers into tape products as a substitution for rice in the application of fermented biotechnological learning. The research used a type of local tubers such as sweet potato, which includes purple sweet potato (purple color), honey sweet potato (yellow color), white sweet potato (white color) and taro (Colocasia esculenta (L.) Schott.), while the control treatment used cassava (Manihot utillisima Crantz) using completely randomized research design. The tests were conducted by looking for the alcohol content and through organoleptic test (taste) as well as the appearance of the tape products by involving 20 researchers as testers. The results showed that the making of tape using tubers through fermentation process produced an average alcohol of 3.994% in honey sweet potatoes; 1.3773% in white sweet potato; 1.0576% in purple sweet potato; 1.3295% in taro and 0.59625% in cassava. The organoleptic test conducted by the panelists showed: honey sweet potato (yell...
ECOTROPHIC : Jurnal Ilmu Lingkungan (Journal of Environmental Science), 2020
This research objective examined the source of pollutants, water quality and water pollution leve... more This research objective examined the source of pollutants, water quality and water pollution level of Buyan Lake. The research conducted field observation to identify the source of pollutants, measuring the water quality and water pollution level of Lake Buyan compared to the standard of environmental quality and damage criteria. This research employed the newest standard measurement and equipment in purpose of water and wastewater inspection. Furthermore, this research used STORET method to analys the pollution level. The results discovered that the pollutant’s source was the settlement and agricultural activities around Buyan Lake. The average value of physical parameters i.e temperature, dissolved residue (TDS), suspended residue (TSS), turbidity and brightness are 23.02 oC; 127 mg.L-1, 4.71 mg L-1, 12.52 JTU; and 133.6 cm respectively. The average values ??of the chemical parameters i.e. pH, DO, BOD5, COD, NO3, NO2, Ammonia and Phosphate are 7.48, 5.95 mg.L-1*, 25.46 mg.L-1*, 42...
Hiperurisemia sudah dikenal sejak dahulu, dan mendapat perhatian medis karena berhubungan dengan ... more Hiperurisemia sudah dikenal sejak dahulu, dan mendapat perhatian medis karena berhubungan dengan berbagai penyakit seperti tekanan darah tinggi, aterosklerosis, penyakit ginjal, diabetes melitus dan penyakit kardiovaskular. Hubungan ini mungkin memiliki penyebab yang signifikan namun, tidak ada mekanisma yang jelas hiperurisemia menyebabkan penyakit kardiovaskular. Hiperurisemia sebagai faktor risiko penyakit kardiovaskular dengan memberikan efek vaskular secara langsung dan menyebabkan kerusakan vaskular. Berdasarkan hasil-hasil penelitian diketahui bahwa Asam urat menyebabkan proliferasi endotel, produksi angiotensin II dan peningkatan stres oksidatif (ROS). Asam urat pada konsentrasi tinggi (hiperurisemia) menimbulkan stress oksidatif dengan meningkatkan pembentukan ROS, menginduksi perubahan vaskular melalui aktivasi jalur sinyal sensitif redoks mengaktifkan mitogen activated protein kinase (MAPKs), tirosin kinase dan faktor transkripsi (NFKB, AP-1, dan HIF-1) merangsang Volume ...
Sore throat is a respiratory infection caused by a bacterial infection of Streptococcus pyogenes.... more Sore throat is a respiratory infection caused by a bacterial infection of Streptococcus pyogenes. Betel leaf is used for loloh (traditional medicine) which has antimicrobial activity. The purpose of this study was to determine the content of active compounds and the antibacterial activity of the boiled water and juice of betel leaf against Streptococcus pyogenes. Explorative research using GC-MS method was used to identify and determine the abundance (content) of active compounds from loloh while the experimental research with the Randomized Post Test Only Control Group Design was carried out by treating the samples in four groups those are the negative control group with distilled water, the positive control group with 30 μg vancomycin, the treatment group with boiled water of betel leaf and betel leaf juice water to prove the antibacterial activity of loloh. The antibacterial activity data of the study results were analyzed statistically nonparametric through the Kruskal-Wallis te...
Background: Betel leaf extracts (Piper betle L.) antioxidant activity and enzyme inhibitors of XO... more Background: Betel leaf extracts (Piper betle L.) antioxidant activity and enzyme inhibitors of XO. Hyperuricemia cause oxidative stress by increasing the formation of reactive oxygen species (ROS) cause lipid peroxidation and oxygenation of low-density lipoprotein cholesterol (LDLc). Objective: The aim of this research was to determine the betel leaf extract as an anti hyperuricemia that can lower the blood uric acid levels and oxidative stress by lowering the levels of MDA and increase the SOD of hyperuricemia of the rat's blood. Method: Experimental research was conducted with the design of The Randomized Post Test Only Control Group Design, on normal Wistar rats (Rattus norvegicus), administered with oxonic potassium (hyperuricemia) and the hyperuricemia rats either given betel leaf extract and allopurinol. After the experiment of uric acid levels, MDA and SOD in rat blood determined. Results: The results showed that the betel leaf extract significantly (p <0.05) lower uric acid levels, MDA and increase levels of SOD in rat blood. There is a positive correlation between the levels of uric acid with MDA levels and a negative correlation, although not significantly with SOD (p >0.05). Conclusion: It can be concluded that the betel leaf extract as an anti-hyperuricemia can lower the uric acid levels and decreases oxidative stress by lowering the levels of MDA and increasing the SOD.
Clinical manifestations of dengue virus infection vary from unspecified fever, dengue fever (DF) ... more Clinical manifestations of dengue virus infection vary from unspecified fever, dengue fever (DF) and dengue hemorrhagic fever (DHF). The fundamental difference in the diagnosis between DF and DHF is plasma leakage, hypotension, thrombocytopenia and hemorrhagic diathesis in DHF. The objectives of the study were to determine the lowest platelet, haematocrit increase, and TNF-α levels in DF and DHF patients as an indication of severity of dengue virus infection. The cross-sectional study was conducted by taking 54 blood samples of patients aged 26-45 years who were infected by dengue virus and grouped into two groups: DF patient group (27 blood samples) and DHF group (27 blood samples). The lowest platelets and hematocrit rise were determined by Hematology Analyzer and the TNF-α levels were determined by ELISA. The data obtained were statistically analyzed by independent Mann-Whitney test. The results showed that the lowest mean platelet counts of DF patients were significantly (p <...
Uploads
Papers by I Made Sumarya