... 16 RA Anderson, F-M. Chambaz, G-Defaye, C. Madani, T. A-~1 e and C-JW Brooks, J. Clzramxogr. ... more ... 16 RA Anderson, F-M. Chambaz, G-Defaye, C. Madani, T. A-~1 e and C-JW Brooks, J. Clzramxogr. ... 23 TA Baiffie, C. Grass, CJW Brooks, C. Madani and EM Ch=baz, in A. Frigerio (Editor), Mass Spectrometry in Bialagy and Medicine, Raven Press, New York, 1974, p-335. ...
ABSTRACT Relationships among taxa of the mosquito tribe Culicini are explored using 169 morpholog... more ABSTRACT Relationships among taxa of the mosquito tribe Culicini are explored using 169 morphological characters from 86 exemplar species representing the four genera and 26 subgenera of Culicini, most species groups and subgroups of subgenus Culex and an outgroup of five species from five other tribes. We analysed the data set, with multistate characters treated as unordered, under implied weights with values of K ranging from 1 to 20, implemented by TNT. Each analysis, except K = 4, produced a single most parsimonious (fittest) cladogram (MPC). The topology of the ingroup was identical for K = 6–11, whereas the MPCs for K = 14–20 differed only in the position of a single species, which occupied the same position in the K = 16 and K = 6–11 topologies. The K = 9 and K = 16 trees were given further consideration. In both these cladograms, Lutzia is sister to a clade comprising genera Culex, Deinocerites and Galindomyia. The two topologies have 13 clades in common, but their arrangements differ primarily because of Culex (Culex) duttoni acting as a ‘rogue’ taxon. We evaluated the effect of removing this species from the K = 9 and K = 16 analyses and chose the refined K = 9 topology as the best hypothesis of relationships within Culicini. Genus Culex is not monophyletic because it includes Deinocerites and Galindomyia as derived members of the New World subgenera. With the exception of subgenera Culex, Eumelanomyia and Neoculex, there is strong support for the monophyly of all genera and subgenera. Subgenus Culex would be monophyletic were four other subgenera included and three other taxa (the Afrotropical Cx. duttoni, Neotropical Cx. apicinus and the Australasian Atriceps Group) excluded.
Journal of Cellular and Molecular Medicine a Journal of Translational Medicine, 2012
Cancer cells exhibit de-regulation of multiple cellular signalling pathways and treatments of var... more Cancer cells exhibit de-regulation of multiple cellular signalling pathways and treatments of various types of cancers with polyphenols are promising. We recently reported the synthesis of a series of 33 novel divanillic and trivanillic polyphenols that displayed anticancer activity, at least in vitro, through inhibiting various kinases. This study revealed that minor chemical modifications of a trivanillate scaffold could convert cytotoxic compounds into cytostatic ones. Compound 13c, a tri-chloro derivative of trivanillic ester, displayed marked inhibitory activities against FGF-, VEGF-, EGF-and Src-related kinases, all of which are implicated not only in angiogenesis but also in the biological aggressiveness of various cancer types. The pan-anti-kinase activity of 13c occurs at less than one-tenth of its mean IC50 in vitro growth inhibitory concentrations towards a panel of 12 cancer cell lines. Of the 26 kinases for which 13c inhibited their activity by Ͼ75%, eight (Yes, Fyn, FGF-R1, EGFR, Btk, Mink, Ret and Itk) are implicated in control of the actin cytoskeleton organization to varying degrees. Compound 13c accordingly impaired the typical organization of the actin cytoskeleton in human U373 glioblastoma cells. The pan-anti-kinase activity and actin cytoskeleton organization impairment provoked by 13c concomitantly occurs with calcium homeostasis impairment but without provoking MDR phenotype activation. All of these anticancer properties enabled 13c to confer therapeutic benefits in vivo in a mouse melanoma pseudometastatic lung model. These data argue in favour of further chemically modifying trivanillates to produce novel and potent anticancer drugs.
In neutral aqueous media pyridoxal isonicotinoylhydrazone (PIH), pyridoxal benzoylhydrazone (PBH)... more In neutral aqueous media pyridoxal isonicotinoylhydrazone (PIH), pyridoxal benzoylhydrazone (PBH), salicylaldehyde isonicotinoylhydrazone (SIH), and salicylaldehyde benzoylhydrazone (SBH), which show interesting potential for iron mobilization in living cells, form bicomplexes with Fe(I1) in two kinetically distinguishable steps. The first is fast and is ascribed to complex formation with a single ligand; second-order rate constants are 1.65 X lo5, 1.70 X lo5, 0.85 X lo5, and 0.60 X lo5 mol-' dm3 S-I for PIH, PBH, SIH, and SBH, respectively. Bicomplex formation is slower and occurs for the same ligands with second-order rate constants 2.45 X lo4, 3.05 X lo4, 4.00 X 104, and 1.50 X lo4 mol-' dm's-l. The affinities of the four chelates to Fe(I1) are rather high, 7.7 X lo9, 12.5 X lo9, 0.60 X lo9, and 0.25 X lo9 mol-2 dm6, but cannot be directly correlated with their abilities to mobilize iron in vivo.
We diagnosed the polarization characteristics of Terahertz emission from a two-color femtosecond ... more We diagnosed the polarization characteristics of Terahertz emission from a two-color femtosecond laser filament when the polarizations of ω and 2 ω beams are orthogonal. We discovered that the THz pulse is elliptically polarized. The generation mechanism could be through four-wave optical rectification inside the filament zone where the inversion symmetry of air is broken.
Proceedings of Spie the International Society For Optical Engineering, 2009
We diagnosed the polarization characteristics of Terahertz (THz) emission from a femtosecond lase... more We diagnosed the polarization characteristics of Terahertz (THz) emission from a femtosecond laser filament in air in the forward direction by using a wire grid polarizer and E-O sampling technique. The experimental results have demonstrated that the investigated THz pulse is elliptical polarized. It indicates that there is a new generation mechanism for THz emission from a laser filament other
Proceedings of Spie the International Society For Optical Engineering, Oct 1, 2005
A system was developed to acquire and analyze the rocket plume in the visible and near-infrared b... more A system was developed to acquire and analyze the rocket plume in the visible and near-infrared bands. The system is designed to be deployed on the field were live rocket firing take place. It is composed of three spectrometers covering the spectrum from 400 nm to 1700 nm, a pair of fast detectors giving the temporal signature at a chosen wavelength band and a pair of CMOS cameras that capture the two-dimensional intensity map of the plume rocket. A detailed description of the instruments that composed the system is described. Results and possible improvement are also presented.
Robinson, la robinsonnade et le monde des choses Volume 35, numéro 1, printemps 1999 URI : id.eru... more Robinson, la robinsonnade et le monde des choses Volume 35, numéro 1, printemps 1999 URI : id.erudit.org/iderudit/036123ar
The cytotoxicity of oxaziridines photogenerated after irradiation of chlordiazepoxide (CDZ) and i... more The cytotoxicity of oxaziridines photogenerated after irradiation of chlordiazepoxide (CDZ) and its metabolites was investigated in vitro by a MTT assay on P388 leukemia and B16 melanoma cell lines and compared with that of the anticancer drug, melphalan. For the longer time-exposure experiment, oxaziridines had the same cytotoxicity as melphalan and this toxicity was higher when oxaziridines were photogenerated in the presence of cells. In conclusion, oxaziridines generated after CDZ, demoxepam, and desmethylchlordiazepoxide ultraviolet irradiation exhibited cytotoxicity activity against cancer cell lines. A possibility of CDZ use within the context of photodynamic therapy as a treatment for small, superficial tumors should not be excluded, because oxaziridines can be generated locally by skin-tumor local irradiation after CDZ topical administration.
... 16 RA Anderson, F-M. Chambaz, G-Defaye, C. Madani, T. A-~1 e and C-JW Brooks, J. Clzramxogr. ... more ... 16 RA Anderson, F-M. Chambaz, G-Defaye, C. Madani, T. A-~1 e and C-JW Brooks, J. Clzramxogr. ... 23 TA Baiffie, C. Grass, CJW Brooks, C. Madani and EM Ch=baz, in A. Frigerio (Editor), Mass Spectrometry in Bialagy and Medicine, Raven Press, New York, 1974, p-335. ...
ABSTRACT Relationships among taxa of the mosquito tribe Culicini are explored using 169 morpholog... more ABSTRACT Relationships among taxa of the mosquito tribe Culicini are explored using 169 morphological characters from 86 exemplar species representing the four genera and 26 subgenera of Culicini, most species groups and subgroups of subgenus Culex and an outgroup of five species from five other tribes. We analysed the data set, with multistate characters treated as unordered, under implied weights with values of K ranging from 1 to 20, implemented by TNT. Each analysis, except K = 4, produced a single most parsimonious (fittest) cladogram (MPC). The topology of the ingroup was identical for K = 6–11, whereas the MPCs for K = 14–20 differed only in the position of a single species, which occupied the same position in the K = 16 and K = 6–11 topologies. The K = 9 and K = 16 trees were given further consideration. In both these cladograms, Lutzia is sister to a clade comprising genera Culex, Deinocerites and Galindomyia. The two topologies have 13 clades in common, but their arrangements differ primarily because of Culex (Culex) duttoni acting as a ‘rogue’ taxon. We evaluated the effect of removing this species from the K = 9 and K = 16 analyses and chose the refined K = 9 topology as the best hypothesis of relationships within Culicini. Genus Culex is not monophyletic because it includes Deinocerites and Galindomyia as derived members of the New World subgenera. With the exception of subgenera Culex, Eumelanomyia and Neoculex, there is strong support for the monophyly of all genera and subgenera. Subgenus Culex would be monophyletic were four other subgenera included and three other taxa (the Afrotropical Cx. duttoni, Neotropical Cx. apicinus and the Australasian Atriceps Group) excluded.
Journal of Cellular and Molecular Medicine a Journal of Translational Medicine, 2012
Cancer cells exhibit de-regulation of multiple cellular signalling pathways and treatments of var... more Cancer cells exhibit de-regulation of multiple cellular signalling pathways and treatments of various types of cancers with polyphenols are promising. We recently reported the synthesis of a series of 33 novel divanillic and trivanillic polyphenols that displayed anticancer activity, at least in vitro, through inhibiting various kinases. This study revealed that minor chemical modifications of a trivanillate scaffold could convert cytotoxic compounds into cytostatic ones. Compound 13c, a tri-chloro derivative of trivanillic ester, displayed marked inhibitory activities against FGF-, VEGF-, EGF-and Src-related kinases, all of which are implicated not only in angiogenesis but also in the biological aggressiveness of various cancer types. The pan-anti-kinase activity of 13c occurs at less than one-tenth of its mean IC50 in vitro growth inhibitory concentrations towards a panel of 12 cancer cell lines. Of the 26 kinases for which 13c inhibited their activity by Ͼ75%, eight (Yes, Fyn, FGF-R1, EGFR, Btk, Mink, Ret and Itk) are implicated in control of the actin cytoskeleton organization to varying degrees. Compound 13c accordingly impaired the typical organization of the actin cytoskeleton in human U373 glioblastoma cells. The pan-anti-kinase activity and actin cytoskeleton organization impairment provoked by 13c concomitantly occurs with calcium homeostasis impairment but without provoking MDR phenotype activation. All of these anticancer properties enabled 13c to confer therapeutic benefits in vivo in a mouse melanoma pseudometastatic lung model. These data argue in favour of further chemically modifying trivanillates to produce novel and potent anticancer drugs.
In neutral aqueous media pyridoxal isonicotinoylhydrazone (PIH), pyridoxal benzoylhydrazone (PBH)... more In neutral aqueous media pyridoxal isonicotinoylhydrazone (PIH), pyridoxal benzoylhydrazone (PBH), salicylaldehyde isonicotinoylhydrazone (SIH), and salicylaldehyde benzoylhydrazone (SBH), which show interesting potential for iron mobilization in living cells, form bicomplexes with Fe(I1) in two kinetically distinguishable steps. The first is fast and is ascribed to complex formation with a single ligand; second-order rate constants are 1.65 X lo5, 1.70 X lo5, 0.85 X lo5, and 0.60 X lo5 mol-' dm3 S-I for PIH, PBH, SIH, and SBH, respectively. Bicomplex formation is slower and occurs for the same ligands with second-order rate constants 2.45 X lo4, 3.05 X lo4, 4.00 X 104, and 1.50 X lo4 mol-' dm's-l. The affinities of the four chelates to Fe(I1) are rather high, 7.7 X lo9, 12.5 X lo9, 0.60 X lo9, and 0.25 X lo9 mol-2 dm6, but cannot be directly correlated with their abilities to mobilize iron in vivo.
We diagnosed the polarization characteristics of Terahertz emission from a two-color femtosecond ... more We diagnosed the polarization characteristics of Terahertz emission from a two-color femtosecond laser filament when the polarizations of ω and 2 ω beams are orthogonal. We discovered that the THz pulse is elliptically polarized. The generation mechanism could be through four-wave optical rectification inside the filament zone where the inversion symmetry of air is broken.
Proceedings of Spie the International Society For Optical Engineering, 2009
We diagnosed the polarization characteristics of Terahertz (THz) emission from a femtosecond lase... more We diagnosed the polarization characteristics of Terahertz (THz) emission from a femtosecond laser filament in air in the forward direction by using a wire grid polarizer and E-O sampling technique. The experimental results have demonstrated that the investigated THz pulse is elliptical polarized. It indicates that there is a new generation mechanism for THz emission from a laser filament other
Proceedings of Spie the International Society For Optical Engineering, Oct 1, 2005
A system was developed to acquire and analyze the rocket plume in the visible and near-infrared b... more A system was developed to acquire and analyze the rocket plume in the visible and near-infrared bands. The system is designed to be deployed on the field were live rocket firing take place. It is composed of three spectrometers covering the spectrum from 400 nm to 1700 nm, a pair of fast detectors giving the temporal signature at a chosen wavelength band and a pair of CMOS cameras that capture the two-dimensional intensity map of the plume rocket. A detailed description of the instruments that composed the system is described. Results and possible improvement are also presented.
Robinson, la robinsonnade et le monde des choses Volume 35, numéro 1, printemps 1999 URI : id.eru... more Robinson, la robinsonnade et le monde des choses Volume 35, numéro 1, printemps 1999 URI : id.erudit.org/iderudit/036123ar
The cytotoxicity of oxaziridines photogenerated after irradiation of chlordiazepoxide (CDZ) and i... more The cytotoxicity of oxaziridines photogenerated after irradiation of chlordiazepoxide (CDZ) and its metabolites was investigated in vitro by a MTT assay on P388 leukemia and B16 melanoma cell lines and compared with that of the anticancer drug, melphalan. For the longer time-exposure experiment, oxaziridines had the same cytotoxicity as melphalan and this toxicity was higher when oxaziridines were photogenerated in the presence of cells. In conclusion, oxaziridines generated after CDZ, demoxepam, and desmethylchlordiazepoxide ultraviolet irradiation exhibited cytotoxicity activity against cancer cell lines. A possibility of CDZ use within the context of photodynamic therapy as a treatment for small, superficial tumors should not be excluded, because oxaziridines can be generated locally by skin-tumor local irradiation after CDZ topical administration.
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