Simon J McCarthy

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Address: Oregon City, Oregon, United States

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Harvard Medical School

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Papers by Simon J McCarthy

Chitosan dressing promotes healing in third degree burns in mice: Gene expression analysis shows biphasic effects for rapid tissue regeneration and decreased fibrotic signaling

Journal of Biomedical Materials Research Part A, 2012

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Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from chitosan and including a polymer mesh material of poly-4-hydroxy butyrate

Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as chitosan

Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities and platelet activation

The Journal of biological chemistry, Jan 23, 2017

Platelet factor 4 (PF4) is produced by platelets with roles in both inflammation and wound healin... more Platelet factor 4 (PF4) is produced by platelets with roles in both inflammation and wound healing. PF4 is stored in platelet α-granules bound to the glycosaminoglycan (GAG) chains of serglycin. This study revealed that platelet serglycin is decorated with chondroitin/dermatan sulfate (CS/DS) and that PF4 binds to these GAG chains. Additionally, PF4 had a higher affinity for endothelial-derived perlecan heparan sulfate (HS) chains than serglycin GAG chains. The binding of PF4 to perlecan was found to inhibit both FGF2 signaling and platelet activation. This study revealed additional insight into the ways in which PF4 interacts with components of the vasculature to modulate cellular events.

Compositions, assemblies, and methods applied during or after a dental procedure to ameliorate fluid loss and/or promote healing, using a hydrophilic polymer sponge structure such as chitosan

Hydrophillic polymer dental sponge

Supple tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan

Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chistosan

Siloxane-Containing Polyurethane-Urea Compositions

Nanomaterial wound dressing assembly

Tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan

Biocompatible and Bioabsorbable Derivatized Chitosan Compositions

The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins

Biomaterials, 2011

Chitosan has been shown to promote initial wound closure events to prevent blood loss. Platelet a... more Chitosan has been shown to promote initial wound closure events to prevent blood loss. Platelet adhesion and activation are crucial early events in these processes after traumatic bleeding leading to thrombus formation. Platelet adhesion to chitosan was found to be enhanced in the presence of adsorbed plasma and extracellular matrix proteins and was found to be primarily mediated by a IIb b 3 integrins, while a 2 b 1 integrins were found to be involved in platelet adhesion to collagen and perlecan. Platelets were found to be activated by chitosan, as shown by an increase in the expression of a IIb b 3 integrins and P-selectin, while the extent of activation was modulated by the presence of proteins including perlecan and fibrinogen. Collagen-coated chitosan was found to activate platelets to the same extent as either chitosan or collagen alone. These data support the role of plasma and extracellular matrix proteins in promoting chitosan mediated platelet adhesion and activation supporting the hypothesis that chitosan promotes wound healing via these interactions.

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Process for the Purification of Polyethers