Arsenic (As) is ubiquitously prevalent in organic and inorganic forms in the environment. Inorgan... more Arsenic (As) is ubiquitously prevalent in organic and inorganic forms in the environment. Inorganic arsenic is classified as Group I carcinogen to both humans and animals. It is causing contamination of water, air, and soil, which has led to chronic arsenicos is as a newly-emerging public-health issue. Acute or chronic exposure of arsenic through groundwater endangers the health of more than 100 million people worldwide specially the residents of the densely populated Indo-Bangladesh Gangetic delta. Microbial reduction of iron oxyhydroxide(FeOOH) that causes major arsenic pollution in the plains of Ganges-Meghna-Brahmaputra Rivers has also been discussed. Long-term exposure to arsenic can cause skin lesions, cancer, pulmonary diseases, cardiovascular diseases, neurotoxicity, and memory loss. Several experimental studies performed in Zimapan, Mexico have shown high concentration of inorganic As in BECs, which can be used as a marker for cancer. With more stringent regulations, arsenic content requires to be reduced to a few parts per billion. Various techniques are being developed to provide arsenic-free drinking water like membranes, coagulation, anion exchange, disposable iron media, softening etc. Several natural methods like bioremediation and phytoremediation are also being widely used.
International Journal of Advance Research, Ideas and Innovations in Technology, 2019
With the development of Big Data, the utilization of NoSQL (Not just SQL) innovation is rising qu... more With the development of Big Data, the utilization of NoSQL (Not just SQL) innovation is rising quickly among web organizations and different undertakings. Advantages incorporate straightforwardness of plan, level scaling and better command over accessibility. NoSQL databases are progressively viewed as a feasible option in contrast to relational databases, as more associations perceive that its pattern less information model is a superior strategy for taking care of the huge volumes of organized, semi-organized and unstructured information, being caught and handled today. For instance, NoSQL databases are regularly used to gather and store web-based life information. This paper means to present the ideas driving NoSQL, gives a survey of applicable writing, features the diverse NoSQL database types, and give contentions to and against embracing NoSQL. A little model application has been created to evaluate the expressed NoSQL benefits and delineate the contrasts between the SQL and N...
Waste management is one of the biggest challenges for the civic bodies. About Rs. 4.7 crores is b... more Waste management is one of the biggest challenges for the civic bodies. About Rs. 4.7 crores is being spent everybody to manage garbage in Delhi alone but result is yet not satisfactory. ‘Dry Wastes’ generated every day in houses and establishments are includes Wood, Clothes, Plastic, Papers, Metals etc. whereas ‘wet waste’ includes kitchen wastes such as vegetable, fruits peels, tea leaves, coffee grounds, bones, fish scales etc. National Green Tribunal (NGT) has directed to enforce segregation of waste at source. But due to contractors-official nexus, most of the wastes are being sent to the dumping ground. Waste management at home is now necessary. Plastic packets containing any food should wash properly and dried before placing into dry waste container, dry waste and wet waste should be kept separately. Wet waste can be used for composting in a process by which dry waste is converted in to compost to be used for kitchen garden. The contribution of rag pickers is significant in t...
Chemolithoautotrophy is a primordial process, where chemical energy converts inorganic carbon to ... more Chemolithoautotrophy is a primordial process, where chemical energy converts inorganic carbon to organic. The prevalence of chemosynthesis was examined in the mangrove clam, Polymesoda erosa, and the ambient sediment at Chorao Island, Mandovi estuary, Goa. The sediment system is reducing, organically rich, high in electron donors, acceptors, and inorganic carbon. This clam thrives by immersing 75-90% of its body in sulfidic sediments. Hence, it is hypothesized that it could have an adaptive mechanism like microbially mediated utilization of reduced sulfur compound, S2O32- (model compound) coupled to inorganic carbon uptake. During spawning, maximum carbonate uptake rates of 449 and 594 nmole C g dry wt-1 h-1 were recorded in the gill and foot, respectively. Next generation sequencing revealed that Thiothrix and other sulfur oxidizers gathered from ambient sediment were present in gill, mantle and foot in the ratio 1:3:14 and 1:5:6, respectively. It is inferred that the clam and thes...
Arsenic (As) is ubiquitously prevalent in organic and inorganic forms in the environment. Inorgan... more Arsenic (As) is ubiquitously prevalent in organic and inorganic forms in the environment. Inorganic arsenic is classified as Group I carcinogen to both humans and animals. It is causing contamination of water, air, and soil, which has led to chronic arsenicos is as a newly-emerging public-health issue. Acute or chronic exposure of arsenic through groundwater endangers the health of more than 100 million people worldwide specially the residents of the densely populated Indo-Bangladesh Gangetic delta. Microbial reduction of iron oxyhydroxide(FeOOH) that causes major arsenic pollution in the plains of Ganges-Meghna-Brahmaputra Rivers has also been discussed. Long-term exposure to arsenic can cause skin lesions, cancer, pulmonary diseases, cardiovascular diseases, neurotoxicity, and memory loss. Several experimental studies performed in Zimapan, Mexico have shown high concentration of inorganic As in BECs, which can be used as a marker for cancer. With more stringent regulations, arsenic content requires to be reduced to a few parts per billion. Various techniques are being developed to provide arsenic-free drinking water like membranes, coagulation, anion exchange, disposable iron media, softening etc. Several natural methods like bioremediation and phytoremediation are also being widely used.
International Journal of Advance Research, Ideas and Innovations in Technology, 2019
With the development of Big Data, the utilization of NoSQL (Not just SQL) innovation is rising qu... more With the development of Big Data, the utilization of NoSQL (Not just SQL) innovation is rising quickly among web organizations and different undertakings. Advantages incorporate straightforwardness of plan, level scaling and better command over accessibility. NoSQL databases are progressively viewed as a feasible option in contrast to relational databases, as more associations perceive that its pattern less information model is a superior strategy for taking care of the huge volumes of organized, semi-organized and unstructured information, being caught and handled today. For instance, NoSQL databases are regularly used to gather and store web-based life information. This paper means to present the ideas driving NoSQL, gives a survey of applicable writing, features the diverse NoSQL database types, and give contentions to and against embracing NoSQL. A little model application has been created to evaluate the expressed NoSQL benefits and delineate the contrasts between the SQL and N...
Waste management is one of the biggest challenges for the civic bodies. About Rs. 4.7 crores is b... more Waste management is one of the biggest challenges for the civic bodies. About Rs. 4.7 crores is being spent everybody to manage garbage in Delhi alone but result is yet not satisfactory. ‘Dry Wastes’ generated every day in houses and establishments are includes Wood, Clothes, Plastic, Papers, Metals etc. whereas ‘wet waste’ includes kitchen wastes such as vegetable, fruits peels, tea leaves, coffee grounds, bones, fish scales etc. National Green Tribunal (NGT) has directed to enforce segregation of waste at source. But due to contractors-official nexus, most of the wastes are being sent to the dumping ground. Waste management at home is now necessary. Plastic packets containing any food should wash properly and dried before placing into dry waste container, dry waste and wet waste should be kept separately. Wet waste can be used for composting in a process by which dry waste is converted in to compost to be used for kitchen garden. The contribution of rag pickers is significant in t...
Chemolithoautotrophy is a primordial process, where chemical energy converts inorganic carbon to ... more Chemolithoautotrophy is a primordial process, where chemical energy converts inorganic carbon to organic. The prevalence of chemosynthesis was examined in the mangrove clam, Polymesoda erosa, and the ambient sediment at Chorao Island, Mandovi estuary, Goa. The sediment system is reducing, organically rich, high in electron donors, acceptors, and inorganic carbon. This clam thrives by immersing 75-90% of its body in sulfidic sediments. Hence, it is hypothesized that it could have an adaptive mechanism like microbially mediated utilization of reduced sulfur compound, S2O32- (model compound) coupled to inorganic carbon uptake. During spawning, maximum carbonate uptake rates of 449 and 594 nmole C g dry wt-1 h-1 were recorded in the gill and foot, respectively. Next generation sequencing revealed that Thiothrix and other sulfur oxidizers gathered from ambient sediment were present in gill, mantle and foot in the ratio 1:3:14 and 1:5:6, respectively. It is inferred that the clam and thes...
Цель работы-изучить возможности клинического применения малеолярного винта из оригинального биоре... more Цель работы-изучить возможности клинического применения малеолярного винта из оригинального биорезорбируемого магниевого сплава МС-10 при проведении остеосинтеза медиальной лодыжки. Материалы и методы. В ходе работы провели апробацию остеосинтеза медиальной лодыжки биорезорбируемыми имплантатами, изготовленными из модифицированного магниевого сплава МС-10, оценили клиническое течение раннего и позднего послеоперационного периода, реакцию мягких тканей, рентгенологическую динамику консолидации перелома и восстановление функции конечности.
INTRODUCTION Cocooning, the vaccination of close contacts of a newborn, is a strategy to limit th... more INTRODUCTION Cocooning, the vaccination of close contacts of a newborn, is a strategy to limit the risk of pertussis and influenza infection among vulnerable infants. METHODS Pregnant women in Colorado and Georgia referred close contacts to an app that provided tailored educational videos about vaccines along with a small pharmacy-based financial incentive for vaccine receipt. The primary objective of this study was to determine the feasibility of implementing this app-based cocooning intervention. RESULTS Two hundred seventy seven contacts were enrolled in this study. Of those who received the educational videos, 96% found them interesting, 100% found them clear to understand, 97% found them helpful, and 99% trusted them. Completion of the videos led to significant increases in influenza vaccine knowledge (p = 0.025), Tdap vaccine knowledge (p < 0.001), and intention to receive these vaccines (p = 0.046). Of the 136 participants who reported receiving influenza vaccine, 41 (30%) reported receiving it at a pharmacy, and of the 66 who reported receiving Tdap vaccine, 15 (23%) reported receiving it at a pharmacy. Of all participants, 80% reported being comfortable receiving vaccines at a pharmacy instead of a doctor's office. The provision of small pharmacy-based financial incentives combined with individually-tailored educational videos about vaccines led to 6.97 (95%CI: 2.25-21.64) times higher odds of self-reported receipt of influenza vaccine than providing small pharmacy-based financial incentives without these videos. No significant difference was found for Tdap vaccine. CONCLUSIONS Tailored vaccine education can positively impact vaccine knowledge and intentions among adults. An app-based referral program providing education and financial incentives for cocooning vaccination at pharmacies is feasible.
International Journal of Bioinformatics Research and Applications, 2020
SCAN DB, acronym for Skin cancer NER database, provides a unique, first of its kind repository fo... more SCAN DB, acronym for Skin cancer NER database, provides a unique, first of its kind repository for understanding the regulatory mechanism of the nucleotide excision repair (NER) pathway, disease dynamics, genetics, clinical information, expression, and evolutionary trajectories of the skin cancers. DNA damage has emerged as a major culprit in cancer and many age related diseases. DNA repair and genomic integrity management have become of prime importance in this cancerous era. One of the significant pathways to remove these bulky lesions is NER pathway, whose deficiencies of NER repair proteins are also associated with the skin cancer prone inherited disorder - Xeroderma pigmentosum and other neurodegenerative abnormalities like Cockayne Syndrome and Trichothiodystrophy. However, a well structured, integrated and comprehensive resource of NER pathway and related skin cancers is presently not available. Therefore, SCAN DB effectively bridges this gap in knowledge. The database can be accessed using the URL: http://bioinfoindia.org/SCANDB//index.php
Цель работы-изучить возможности клинического применения малеолярного винта из оригинального биоре... more Цель работы-изучить возможности клинического применения малеолярного винта из оригинального биорезорбируемого магниевого сплава МС-10 при проведении остеосинтеза медиальной лодыжки. Материалы и методы. В ходе работы провели апробацию остеосинтеза медиальной лодыжки биорезорбируемыми имплантатами, изготовленными из модифицированного магниевого сплава МС-10, оценили клиническое течение раннего и позднего послеоперационного периода, реакцию мягких тканей, рентгенологическую динамику консолидации перелома и восстановление функции конечности.
INTRODUCTION Cocooning, the vaccination of close contacts of a newborn, is a strategy to limit th... more INTRODUCTION Cocooning, the vaccination of close contacts of a newborn, is a strategy to limit the risk of pertussis and influenza infection among vulnerable infants. METHODS Pregnant women in Colorado and Georgia referred close contacts to an app that provided tailored educational videos about vaccines along with a small pharmacy-based financial incentive for vaccine receipt. The primary objective of this study was to determine the feasibility of implementing this app-based cocooning intervention. RESULTS Two hundred seventy seven contacts were enrolled in this study. Of those who received the educational videos, 96% found them interesting, 100% found them clear to understand, 97% found them helpful, and 99% trusted them. Completion of the videos led to significant increases in influenza vaccine knowledge (p = 0.025), Tdap vaccine knowledge (p < 0.001), and intention to receive these vaccines (p = 0.046). Of the 136 participants who reported receiving influenza vaccine, 41 (30%) reported receiving it at a pharmacy, and of the 66 who reported receiving Tdap vaccine, 15 (23%) reported receiving it at a pharmacy. Of all participants, 80% reported being comfortable receiving vaccines at a pharmacy instead of a doctor's office. The provision of small pharmacy-based financial incentives combined with individually-tailored educational videos about vaccines led to 6.97 (95%CI: 2.25-21.64) times higher odds of self-reported receipt of influenza vaccine than providing small pharmacy-based financial incentives without these videos. No significant difference was found for Tdap vaccine. CONCLUSIONS Tailored vaccine education can positively impact vaccine knowledge and intentions among adults. An app-based referral program providing education and financial incentives for cocooning vaccination at pharmacies is feasible.
The role of miRNAs in determining human neural stem cell (NSC) fate remains elusive despite their... more The role of miRNAs in determining human neural stem cell (NSC) fate remains elusive despite their high expression in the developing nervous system. In this study, we investigate the role of miR-137, a brain-enriched miRNA, in determining the fate of human induced pluripotent stem cells-derived NSCs (hiNSCs). We show that ectopic expression of miR-137 in hiNSCs reduces proliferation and accelerates neuronal differentiation and migration. TargetScan and MicroT-CDS predict myocyte enhancer factor-2A (MEF2A), a transcription factor that regulates peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) transcription, as a target of miR-137. Using a reporter assay, we validate MEF2A as a downstream target of miR-137. Our results indicate that reduced levels of MEF2A reduce the transcription of PGC1α, which in turn impacts mitochondrial dynamics. Notably, miR-137 accelerates mitochondrial biogenesis in a PGC1α independent manner by upregulating nuclear factor erythroid 2 (NFE2...
International Journal of Bioinformatics Research and Applications, 2020
SCAN DB, acronym for Skin cancer NER database, provides a unique, first of its kind repository fo... more SCAN DB, acronym for Skin cancer NER database, provides a unique, first of its kind repository for understanding the regulatory mechanism of the nucleotide excision repair (NER) pathway, disease dynamics, genetics, clinical information, expression, and evolutionary trajectories of the skin cancers. DNA damage has emerged as a major culprit in cancer and many age related diseases. DNA repair and genomic integrity management have become of prime importance in this cancerous era. One of the significant pathways to remove these bulky lesions is NER pathway, whose deficiencies of NER repair proteins are also associated with the skin cancer prone inherited disorder - Xeroderma pigmentosum and other neurodegenerative abnormalities like Cockayne Syndrome and Trichothiodystrophy. However, a well structured, integrated and comprehensive resource of NER pathway and related skin cancers is presently not available. Therefore, SCAN DB effectively bridges this gap in knowledge. The database can be accessed using the URL: http://bioinfoindia.org/SCANDB//index.php
The role of miRNAs in determining human neural stem cell (NSC) fate remains elusive despite their... more The role of miRNAs in determining human neural stem cell (NSC) fate remains elusive despite their high expression in the developing nervous system. In this study, we investigate the role of miR-137, a brain-enriched miRNA, in determining the fate of human induced pluripotent stem cells-derived NSCs (hiNSCs). We show that ectopic expression of miR-137 in hiNSCs reduces proliferation and accelerates neuronal differentiation and migration. TargetScan and MicroT-CDS predict myocyte enhancer factor-2A (MEF2A), a transcription factor that regulates peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) transcription, as a target of miR-137. Using a reporter assay, we validate MEF2A as a downstream target of miR-137. Our results indicate that reduced levels of MEF2A reduce the transcription of PGC1α, which in turn impacts mitochondrial dynamics. Notably, miR-137 accelerates mitochondrial biogenesis in a PGC1α independent manner by upregulating nuclear factor erythroid 2 (NFE2...
Objective Many American adults are insufficiently active. Digital health programs are designed to... more Objective Many American adults are insufficiently active. Digital health programs are designed to motivate this population to engage in regular physical activity and often rely on wearable devices and apps to objectively measure physical activity for a large number of participants. The purpose of this epidemiological study was to analyze the rates of physical activity among participants in a digital health program. Method We conducted a cross-sectional study of participants enrolled in a digital health program between January 2014 and December 2016. All activity data were objectively collected through wearable devices. Results Participants ( n = 241,013) were on average 39.7 years old and 65.7% were female. Participants walked on average 3.72 miles per day. Overall, 5.3% and 21.8% of participants were being treated with diabetes and cardiovascular medications respectively, but these rates varied across young, middle and older adults. Participants of all ages being treated with card...
Objective Many American adults are insufficiently active. Digital health programs are designed to... more Objective Many American adults are insufficiently active. Digital health programs are designed to motivate this population to engage in regular physical activity and often rely on wearable devices and apps to objectively measure physical activity for a large number of participants. The purpose of this epidemiological study was to analyze the rates of physical activity among participants in a digital health program. Method We conducted a cross-sectional study of participants enrolled in a digital health program between January 2014 and December 2016. All activity data were objectively collected through wearable devices. Results Participants ( n = 241,013) were on average 39.7 years old and 65.7% were female. Participants walked on average 3.72 miles per day. Overall, 5.3% and 21.8% of participants were being treated with diabetes and cardiovascular medications respectively, but these rates varied across young, middle and older adults. Participants of all ages being treated with card...
Arsenic (As) is ubiquitously prevalent in organic and inorganic forms in the environment. Inorgan... more Arsenic (As) is ubiquitously prevalent in organic and inorganic forms in the environment. Inorganic arsenic is classified as Group I carcinogen to both humans and animals. It is causing contamination of water, air, and soil, which has led to chronic arsenicos is as a newly-emerging public-health issue. Acute or chronic exposure of arsenic through groundwater endangers the health of more than 100 million people worldwide specially the residents of the densely populated Indo-Bangladesh Gangetic delta. Microbial reduction of iron oxyhydroxide(FeOOH) that causes major arsenic pollution in the plains of Ganges-Meghna-Brahmaputra Rivers has also been discussed. Long-term exposure to arsenic can cause skin lesions, cancer, pulmonary diseases, cardiovascular diseases, neurotoxicity, and memory loss. Several experimental studies performed in Zimapan, Mexico have shown high concentration of inorganic As in BECs, which can be used as a marker for cancer. With more stringent regulations, arsenic content requires to be reduced to a few parts per billion. Various techniques are being developed to provide arsenic-free drinking water like membranes, coagulation, anion exchange, disposable iron media, softening etc. Several natural methods like bioremediation and phytoremediation are also being widely used.
International Journal of Advance Research, Ideas and Innovations in Technology, 2019
With the development of Big Data, the utilization of NoSQL (Not just SQL) innovation is rising qu... more With the development of Big Data, the utilization of NoSQL (Not just SQL) innovation is rising quickly among web organizations and different undertakings. Advantages incorporate straightforwardness of plan, level scaling and better command over accessibility. NoSQL databases are progressively viewed as a feasible option in contrast to relational databases, as more associations perceive that its pattern less information model is a superior strategy for taking care of the huge volumes of organized, semi-organized and unstructured information, being caught and handled today. For instance, NoSQL databases are regularly used to gather and store web-based life information. This paper means to present the ideas driving NoSQL, gives a survey of applicable writing, features the diverse NoSQL database types, and give contentions to and against embracing NoSQL. A little model application has been created to evaluate the expressed NoSQL benefits and delineate the contrasts between the SQL and N...
Waste management is one of the biggest challenges for the civic bodies. About Rs. 4.7 crores is b... more Waste management is one of the biggest challenges for the civic bodies. About Rs. 4.7 crores is being spent everybody to manage garbage in Delhi alone but result is yet not satisfactory. ‘Dry Wastes’ generated every day in houses and establishments are includes Wood, Clothes, Plastic, Papers, Metals etc. whereas ‘wet waste’ includes kitchen wastes such as vegetable, fruits peels, tea leaves, coffee grounds, bones, fish scales etc. National Green Tribunal (NGT) has directed to enforce segregation of waste at source. But due to contractors-official nexus, most of the wastes are being sent to the dumping ground. Waste management at home is now necessary. Plastic packets containing any food should wash properly and dried before placing into dry waste container, dry waste and wet waste should be kept separately. Wet waste can be used for composting in a process by which dry waste is converted in to compost to be used for kitchen garden. The contribution of rag pickers is significant in t...
Chemolithoautotrophy is a primordial process, where chemical energy converts inorganic carbon to ... more Chemolithoautotrophy is a primordial process, where chemical energy converts inorganic carbon to organic. The prevalence of chemosynthesis was examined in the mangrove clam, Polymesoda erosa, and the ambient sediment at Chorao Island, Mandovi estuary, Goa. The sediment system is reducing, organically rich, high in electron donors, acceptors, and inorganic carbon. This clam thrives by immersing 75-90% of its body in sulfidic sediments. Hence, it is hypothesized that it could have an adaptive mechanism like microbially mediated utilization of reduced sulfur compound, S2O32- (model compound) coupled to inorganic carbon uptake. During spawning, maximum carbonate uptake rates of 449 and 594 nmole C g dry wt-1 h-1 were recorded in the gill and foot, respectively. Next generation sequencing revealed that Thiothrix and other sulfur oxidizers gathered from ambient sediment were present in gill, mantle and foot in the ratio 1:3:14 and 1:5:6, respectively. It is inferred that the clam and thes...
Arsenic (As) is ubiquitously prevalent in organic and inorganic forms in the environment. Inorgan... more Arsenic (As) is ubiquitously prevalent in organic and inorganic forms in the environment. Inorganic arsenic is classified as Group I carcinogen to both humans and animals. It is causing contamination of water, air, and soil, which has led to chronic arsenicos is as a newly-emerging public-health issue. Acute or chronic exposure of arsenic through groundwater endangers the health of more than 100 million people worldwide specially the residents of the densely populated Indo-Bangladesh Gangetic delta. Microbial reduction of iron oxyhydroxide(FeOOH) that causes major arsenic pollution in the plains of Ganges-Meghna-Brahmaputra Rivers has also been discussed. Long-term exposure to arsenic can cause skin lesions, cancer, pulmonary diseases, cardiovascular diseases, neurotoxicity, and memory loss. Several experimental studies performed in Zimapan, Mexico have shown high concentration of inorganic As in BECs, which can be used as a marker for cancer. With more stringent regulations, arsenic content requires to be reduced to a few parts per billion. Various techniques are being developed to provide arsenic-free drinking water like membranes, coagulation, anion exchange, disposable iron media, softening etc. Several natural methods like bioremediation and phytoremediation are also being widely used.
International Journal of Advance Research, Ideas and Innovations in Technology, 2019
With the development of Big Data, the utilization of NoSQL (Not just SQL) innovation is rising qu... more With the development of Big Data, the utilization of NoSQL (Not just SQL) innovation is rising quickly among web organizations and different undertakings. Advantages incorporate straightforwardness of plan, level scaling and better command over accessibility. NoSQL databases are progressively viewed as a feasible option in contrast to relational databases, as more associations perceive that its pattern less information model is a superior strategy for taking care of the huge volumes of organized, semi-organized and unstructured information, being caught and handled today. For instance, NoSQL databases are regularly used to gather and store web-based life information. This paper means to present the ideas driving NoSQL, gives a survey of applicable writing, features the diverse NoSQL database types, and give contentions to and against embracing NoSQL. A little model application has been created to evaluate the expressed NoSQL benefits and delineate the contrasts between the SQL and N...
Waste management is one of the biggest challenges for the civic bodies. About Rs. 4.7 crores is b... more Waste management is one of the biggest challenges for the civic bodies. About Rs. 4.7 crores is being spent everybody to manage garbage in Delhi alone but result is yet not satisfactory. ‘Dry Wastes’ generated every day in houses and establishments are includes Wood, Clothes, Plastic, Papers, Metals etc. whereas ‘wet waste’ includes kitchen wastes such as vegetable, fruits peels, tea leaves, coffee grounds, bones, fish scales etc. National Green Tribunal (NGT) has directed to enforce segregation of waste at source. But due to contractors-official nexus, most of the wastes are being sent to the dumping ground. Waste management at home is now necessary. Plastic packets containing any food should wash properly and dried before placing into dry waste container, dry waste and wet waste should be kept separately. Wet waste can be used for composting in a process by which dry waste is converted in to compost to be used for kitchen garden. The contribution of rag pickers is significant in t...
Chemolithoautotrophy is a primordial process, where chemical energy converts inorganic carbon to ... more Chemolithoautotrophy is a primordial process, where chemical energy converts inorganic carbon to organic. The prevalence of chemosynthesis was examined in the mangrove clam, Polymesoda erosa, and the ambient sediment at Chorao Island, Mandovi estuary, Goa. The sediment system is reducing, organically rich, high in electron donors, acceptors, and inorganic carbon. This clam thrives by immersing 75-90% of its body in sulfidic sediments. Hence, it is hypothesized that it could have an adaptive mechanism like microbially mediated utilization of reduced sulfur compound, S2O32- (model compound) coupled to inorganic carbon uptake. During spawning, maximum carbonate uptake rates of 449 and 594 nmole C g dry wt-1 h-1 were recorded in the gill and foot, respectively. Next generation sequencing revealed that Thiothrix and other sulfur oxidizers gathered from ambient sediment were present in gill, mantle and foot in the ratio 1:3:14 and 1:5:6, respectively. It is inferred that the clam and thes...
Цель работы-изучить возможности клинического применения малеолярного винта из оригинального биоре... more Цель работы-изучить возможности клинического применения малеолярного винта из оригинального биорезорбируемого магниевого сплава МС-10 при проведении остеосинтеза медиальной лодыжки. Материалы и методы. В ходе работы провели апробацию остеосинтеза медиальной лодыжки биорезорбируемыми имплантатами, изготовленными из модифицированного магниевого сплава МС-10, оценили клиническое течение раннего и позднего послеоперационного периода, реакцию мягких тканей, рентгенологическую динамику консолидации перелома и восстановление функции конечности.
INTRODUCTION Cocooning, the vaccination of close contacts of a newborn, is a strategy to limit th... more INTRODUCTION Cocooning, the vaccination of close contacts of a newborn, is a strategy to limit the risk of pertussis and influenza infection among vulnerable infants. METHODS Pregnant women in Colorado and Georgia referred close contacts to an app that provided tailored educational videos about vaccines along with a small pharmacy-based financial incentive for vaccine receipt. The primary objective of this study was to determine the feasibility of implementing this app-based cocooning intervention. RESULTS Two hundred seventy seven contacts were enrolled in this study. Of those who received the educational videos, 96% found them interesting, 100% found them clear to understand, 97% found them helpful, and 99% trusted them. Completion of the videos led to significant increases in influenza vaccine knowledge (p = 0.025), Tdap vaccine knowledge (p < 0.001), and intention to receive these vaccines (p = 0.046). Of the 136 participants who reported receiving influenza vaccine, 41 (30%) reported receiving it at a pharmacy, and of the 66 who reported receiving Tdap vaccine, 15 (23%) reported receiving it at a pharmacy. Of all participants, 80% reported being comfortable receiving vaccines at a pharmacy instead of a doctor's office. The provision of small pharmacy-based financial incentives combined with individually-tailored educational videos about vaccines led to 6.97 (95%CI: 2.25-21.64) times higher odds of self-reported receipt of influenza vaccine than providing small pharmacy-based financial incentives without these videos. No significant difference was found for Tdap vaccine. CONCLUSIONS Tailored vaccine education can positively impact vaccine knowledge and intentions among adults. An app-based referral program providing education and financial incentives for cocooning vaccination at pharmacies is feasible.
International Journal of Bioinformatics Research and Applications, 2020
SCAN DB, acronym for Skin cancer NER database, provides a unique, first of its kind repository fo... more SCAN DB, acronym for Skin cancer NER database, provides a unique, first of its kind repository for understanding the regulatory mechanism of the nucleotide excision repair (NER) pathway, disease dynamics, genetics, clinical information, expression, and evolutionary trajectories of the skin cancers. DNA damage has emerged as a major culprit in cancer and many age related diseases. DNA repair and genomic integrity management have become of prime importance in this cancerous era. One of the significant pathways to remove these bulky lesions is NER pathway, whose deficiencies of NER repair proteins are also associated with the skin cancer prone inherited disorder - Xeroderma pigmentosum and other neurodegenerative abnormalities like Cockayne Syndrome and Trichothiodystrophy. However, a well structured, integrated and comprehensive resource of NER pathway and related skin cancers is presently not available. Therefore, SCAN DB effectively bridges this gap in knowledge. The database can be accessed using the URL: http://bioinfoindia.org/SCANDB//index.php
Цель работы-изучить возможности клинического применения малеолярного винта из оригинального биоре... more Цель работы-изучить возможности клинического применения малеолярного винта из оригинального биорезорбируемого магниевого сплава МС-10 при проведении остеосинтеза медиальной лодыжки. Материалы и методы. В ходе работы провели апробацию остеосинтеза медиальной лодыжки биорезорбируемыми имплантатами, изготовленными из модифицированного магниевого сплава МС-10, оценили клиническое течение раннего и позднего послеоперационного периода, реакцию мягких тканей, рентгенологическую динамику консолидации перелома и восстановление функции конечности.
INTRODUCTION Cocooning, the vaccination of close contacts of a newborn, is a strategy to limit th... more INTRODUCTION Cocooning, the vaccination of close contacts of a newborn, is a strategy to limit the risk of pertussis and influenza infection among vulnerable infants. METHODS Pregnant women in Colorado and Georgia referred close contacts to an app that provided tailored educational videos about vaccines along with a small pharmacy-based financial incentive for vaccine receipt. The primary objective of this study was to determine the feasibility of implementing this app-based cocooning intervention. RESULTS Two hundred seventy seven contacts were enrolled in this study. Of those who received the educational videos, 96% found them interesting, 100% found them clear to understand, 97% found them helpful, and 99% trusted them. Completion of the videos led to significant increases in influenza vaccine knowledge (p = 0.025), Tdap vaccine knowledge (p < 0.001), and intention to receive these vaccines (p = 0.046). Of the 136 participants who reported receiving influenza vaccine, 41 (30%) reported receiving it at a pharmacy, and of the 66 who reported receiving Tdap vaccine, 15 (23%) reported receiving it at a pharmacy. Of all participants, 80% reported being comfortable receiving vaccines at a pharmacy instead of a doctor's office. The provision of small pharmacy-based financial incentives combined with individually-tailored educational videos about vaccines led to 6.97 (95%CI: 2.25-21.64) times higher odds of self-reported receipt of influenza vaccine than providing small pharmacy-based financial incentives without these videos. No significant difference was found for Tdap vaccine. CONCLUSIONS Tailored vaccine education can positively impact vaccine knowledge and intentions among adults. An app-based referral program providing education and financial incentives for cocooning vaccination at pharmacies is feasible.
The role of miRNAs in determining human neural stem cell (NSC) fate remains elusive despite their... more The role of miRNAs in determining human neural stem cell (NSC) fate remains elusive despite their high expression in the developing nervous system. In this study, we investigate the role of miR-137, a brain-enriched miRNA, in determining the fate of human induced pluripotent stem cells-derived NSCs (hiNSCs). We show that ectopic expression of miR-137 in hiNSCs reduces proliferation and accelerates neuronal differentiation and migration. TargetScan and MicroT-CDS predict myocyte enhancer factor-2A (MEF2A), a transcription factor that regulates peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) transcription, as a target of miR-137. Using a reporter assay, we validate MEF2A as a downstream target of miR-137. Our results indicate that reduced levels of MEF2A reduce the transcription of PGC1α, which in turn impacts mitochondrial dynamics. Notably, miR-137 accelerates mitochondrial biogenesis in a PGC1α independent manner by upregulating nuclear factor erythroid 2 (NFE2...
International Journal of Bioinformatics Research and Applications, 2020
SCAN DB, acronym for Skin cancer NER database, provides a unique, first of its kind repository fo... more SCAN DB, acronym for Skin cancer NER database, provides a unique, first of its kind repository for understanding the regulatory mechanism of the nucleotide excision repair (NER) pathway, disease dynamics, genetics, clinical information, expression, and evolutionary trajectories of the skin cancers. DNA damage has emerged as a major culprit in cancer and many age related diseases. DNA repair and genomic integrity management have become of prime importance in this cancerous era. One of the significant pathways to remove these bulky lesions is NER pathway, whose deficiencies of NER repair proteins are also associated with the skin cancer prone inherited disorder - Xeroderma pigmentosum and other neurodegenerative abnormalities like Cockayne Syndrome and Trichothiodystrophy. However, a well structured, integrated and comprehensive resource of NER pathway and related skin cancers is presently not available. Therefore, SCAN DB effectively bridges this gap in knowledge. The database can be accessed using the URL: http://bioinfoindia.org/SCANDB//index.php
The role of miRNAs in determining human neural stem cell (NSC) fate remains elusive despite their... more The role of miRNAs in determining human neural stem cell (NSC) fate remains elusive despite their high expression in the developing nervous system. In this study, we investigate the role of miR-137, a brain-enriched miRNA, in determining the fate of human induced pluripotent stem cells-derived NSCs (hiNSCs). We show that ectopic expression of miR-137 in hiNSCs reduces proliferation and accelerates neuronal differentiation and migration. TargetScan and MicroT-CDS predict myocyte enhancer factor-2A (MEF2A), a transcription factor that regulates peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) transcription, as a target of miR-137. Using a reporter assay, we validate MEF2A as a downstream target of miR-137. Our results indicate that reduced levels of MEF2A reduce the transcription of PGC1α, which in turn impacts mitochondrial dynamics. Notably, miR-137 accelerates mitochondrial biogenesis in a PGC1α independent manner by upregulating nuclear factor erythroid 2 (NFE2...
Objective Many American adults are insufficiently active. Digital health programs are designed to... more Objective Many American adults are insufficiently active. Digital health programs are designed to motivate this population to engage in regular physical activity and often rely on wearable devices and apps to objectively measure physical activity for a large number of participants. The purpose of this epidemiological study was to analyze the rates of physical activity among participants in a digital health program. Method We conducted a cross-sectional study of participants enrolled in a digital health program between January 2014 and December 2016. All activity data were objectively collected through wearable devices. Results Participants ( n = 241,013) were on average 39.7 years old and 65.7% were female. Participants walked on average 3.72 miles per day. Overall, 5.3% and 21.8% of participants were being treated with diabetes and cardiovascular medications respectively, but these rates varied across young, middle and older adults. Participants of all ages being treated with card...
Objective Many American adults are insufficiently active. Digital health programs are designed to... more Objective Many American adults are insufficiently active. Digital health programs are designed to motivate this population to engage in regular physical activity and often rely on wearable devices and apps to objectively measure physical activity for a large number of participants. The purpose of this epidemiological study was to analyze the rates of physical activity among participants in a digital health program. Method We conducted a cross-sectional study of participants enrolled in a digital health program between January 2014 and December 2016. All activity data were objectively collected through wearable devices. Results Participants ( n = 241,013) were on average 39.7 years old and 65.7% were female. Participants walked on average 3.72 miles per day. Overall, 5.3% and 21.8% of participants were being treated with diabetes and cardiovascular medications respectively, but these rates varied across young, middle and older adults. Participants of all ages being treated with card...
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Papers by Tanya Singh