Hi darksand123, the game supports TTS and has a number of blind-friendly features to make sure it's playable for anyone who may need them. However as per the sticky post in the forum here, for reasons outside of my control the itch.io version isn't supported and Steam is required.

You can grab (and wishlist it while you're there!) the game's demo on Steam and see how it plays for you; I've had a lot of players with vision considerations test it out and I believe at this stage the game is at parity in terms of functionality.

https://store.steampowered.com/app/1074830/Alcyone_The_Last_City/