Content-Length: 157720 | pFad | https://medicalxpress.com/news/2024-12-multiple-sclerosis-brain-atlas-pave.html

Multiple sclerosis brain atlas could pave way for personalized treatments

This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

trusted source

proofread

Multiple sclerosis brain atlas could pave way for personalized treatments

Multiple sclerosis brain atlas: Researchers develop map showing gene expressions for people with MS
Graphical abstract. Credit: Neuron (2024). DOI: 10.1016/j.neuron.2024.11.016

An international research team, including researchers at Karolinska Institutet, has mapped the genes expressed in the brain cells of people with multiple sclerosis (MS). The atlas, which is presented in the journal Neuron, is hoped to contribute to more personalized treatment of MS in the future.

MS is a chronic inflammatory disease that affects the brain and and usually affects people in their 30s and 40s. Symptoms vary, and some people have much more disability than others.

Currently, MS treatments target in the blood, stopping them from reaching the brain and causing damage. These are very effective in the early phase of MS. But to help treat when their MS is more progressive, researchers need to find treatments that act on the brain cells themselves.

However, there is limited understanding of how brain cells are affected in people with MS over their lives or why there is a huge diversity in how the condition affects people.

Now, an international research team including researchers at KI, Edinburgh University and Hoffmann-La Roche in Basel, among other institutions, has created an " of MS brain cells" at an individual cell resolution, by examining the largest ever number of brains from deceased people with MS, comprising more than half a million brain cells.

Four groups with different brain cell profiles

Using information on which genes are expressed in the of people with MS, the researchers were able to categorize them into four groups with different brain cell profiles.

"Since each patient group presented different signatures regarding the genes that are active in cells in the brain, they might respond to treatments differently, which highlights the need for more personalized of MS," says Gonçalo Castelo-Branco, professor at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet and one of the main authors of the paper.

So far, researchers have observed these subgroups using post-mortem brain tissue.

"To help treat MS, we need to work out how to group people with MS using blood tests," says Anna Williams, professor at the University of Edinburgh who led the study. "We could then design specifically for these subgroups, which could help us get the right drugs to the right people."

More information: snRNAseq stratifies multiple sclerosis patients into distinct white matter glial responses, Neuron (2024). DOI: 10.1016/j.neuron.2024.11.016. www.cell.com/neuron/fulltext/S0896-6273(24)00873-0

Journal information: Neuron
Citation: Multiple sclerosis brain atlas could pave way for personalized treatments (2024, December 20) retrieved 23 December 2024 from https://medicalxpress.com/news/2024-12-multiple-sclerosis-brain-atlas-pave.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Cellular architecture of lesions in multiple sclerosis now mapped out

2 shares

Feedback to editors









ApplySandwichStrip

pFad - (p)hone/(F)rame/(a)nonymizer/(d)eclutterfier!      Saves Data!


--- a PPN by Garber Painting Akron. With Image Size Reduction included!

Fetched URL: https://medicalxpress.com/news/2024-12-multiple-sclerosis-brain-atlas-pave.html

Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy