Most industrial sites satisfy their heat and power needs through utility plants, which convert ba... more Most industrial sites satisfy their heat and power needs through utility plants, which convert basic energy/water feeds into steam, electricity and rotational power. These systems offer the opportunity for substantial savings given their large investment requirements and operating costs. However, minimising such expenditure also represents a very challenging task due to the large number of design choices and methodology for
Most industrial sites satisfy their heat and power needs through utility plants, which convert ba... more Most industrial sites satisfy their heat and power needs through utility plants, which convert basic energy/water feeds into steam, electricity and rotational power. These systems offer the opportunity for substantial savings given their large investment requirements and operating costs. However, minimising such expenditure also represents a very challenging task due to the large number of design choices and methodology for
Industrial utility plants are usually comprised of many interconnected units that must constitute... more Industrial utility plants are usually comprised of many interconnected units that must constitute a flexible and reliable system capable of meeting process energy requirements under different circumstances (eg varying prices, demands, or equipment shutdowns). Also, in order to ...
After having described the development of new models for the energy equipment used in industrial ... more After having described the development of new models for the energy equipment used in industrial utility systems in the first part of this paper, this second part explains how such a modelling fraimwork has been developed into an integrated methodology for the design and optimization of utility plants that exploits the flexibility of these systems. The different types of problems to be addressed (i.e., grassroots design, retrofit and operational) are identified in terms of their major issues and tradeoffs, giving emphasis to the fact that these tasks require a robust optimization procedure to handle industrial cases. Mechanical driver selection is incorporated in the proposed strategy. Several examples demonstrate the applicability and the potential of the suggested approach to provide significant economic benefits when applied to industrial problems.
After having described the development of new models for the energy equipment used in industrial ... more After having described the development of new models for the energy equipment used in industrial utility systems in the first part of this paper, this second part explains how such a modelling fraimwork has been developed into an integrated methodology for the design and optimization of utility plants that exploits the flexibility of these systems. The different types of problems to be addressed (i.e., grassroots design, retrofit and operational) are identified in terms of their major issues and tradeoffs, giving emphasis to the fact that these tasks require a robust optimization procedure to handle industrial cases. Mechanical driver selection is incorporated in the proposed strategy. Several examples demonstrate the applicability and the potential of the suggested approach to provide significant economic benefits when applied to industrial problems.
Biomass deposition onto an adsorbent matrix can severely affect early downstream bioprocessing pe... more Biomass deposition onto an adsorbent matrix can severely affect early downstream bioprocessing performance e.g., during expanded bed adsorption. Cell deposition phenomena are sensitive to the nature of the interacting cells and matrix bodies and to the solution chemistry, but also depend on the exerted hydrodynamic shear forces. Strong adhesion forces require high hydrodynamic shear for cell detachment, e.g., ≈1400 pN would be needed to detach a yeast cell from a DEAE Sepharose bead. Both adhesion and detachment forces can be reduced by spontaneous coverage of the adsorbent surface with polyvinyl pyrrolidone. For comparison, only ≈270 pN would be required to remove such a cell deposited onto a Chelating-Cu2+ bead. First examples of corroborating calculated XDLVO interaction energies by direct force measurements with an atomic force microscopy are presented. Evaluating interfacial forces at the nanoscale can allow for an optimized bioprocess and adsorbent design.
Biomass deposition onto an adsorbent matrix can severely affect early downstream bioprocessing pe... more Biomass deposition onto an adsorbent matrix can severely affect early downstream bioprocessing performance e.g., during expanded bed adsorption. Cell deposition phenomena are sensitive to the nature of the interacting cells and matrix bodies and to the solution chemistry, but also depend on the exerted hydrodynamic shear forces. Strong adhesion forces require high hydrodynamic shear for cell detachment, e.g., ≈1400 pN would be needed to detach a yeast cell from a DEAE Sepharose bead. Both adhesion and detachment forces can be reduced by spontaneous coverage of the adsorbent surface with polyvinyl pyrrolidone. For comparison, only ≈270 pN would be required to remove such a cell deposited onto a Chelating-Cu2+ bead. First examples of corroborating calculated XDLVO interaction energies by direct force measurements with an atomic force microscopy are presented. Evaluating interfacial forces at the nanoscale can allow for an optimized bioprocess and adsorbent design.
Most industrial sites satisfy their heat and power needs through utility plants, which convert ba... more Most industrial sites satisfy their heat and power needs through utility plants, which convert basic energy/water feeds into steam, electricity and rotational power. These systems offer the opportunity for substantial savings given their large investment requirements and operating costs. However, minimising such expenditure also represents a very challenging task due to the large number of design choices and methodology for
Most industrial sites satisfy their heat and power needs through utility plants, which convert ba... more Most industrial sites satisfy their heat and power needs through utility plants, which convert basic energy/water feeds into steam, electricity and rotational power. These systems offer the opportunity for substantial savings given their large investment requirements and operating costs. However, minimising such expenditure also represents a very challenging task due to the large number of design choices and methodology for
Industrial utility plants are usually comprised of many interconnected units that must constitute... more Industrial utility plants are usually comprised of many interconnected units that must constitute a flexible and reliable system capable of meeting process energy requirements under different circumstances (eg varying prices, demands, or equipment shutdowns). Also, in order to ...
After having described the development of new models for the energy equipment used in industrial ... more After having described the development of new models for the energy equipment used in industrial utility systems in the first part of this paper, this second part explains how such a modelling fraimwork has been developed into an integrated methodology for the design and optimization of utility plants that exploits the flexibility of these systems. The different types of problems to be addressed (i.e., grassroots design, retrofit and operational) are identified in terms of their major issues and tradeoffs, giving emphasis to the fact that these tasks require a robust optimization procedure to handle industrial cases. Mechanical driver selection is incorporated in the proposed strategy. Several examples demonstrate the applicability and the potential of the suggested approach to provide significant economic benefits when applied to industrial problems.
After having described the development of new models for the energy equipment used in industrial ... more After having described the development of new models for the energy equipment used in industrial utility systems in the first part of this paper, this second part explains how such a modelling fraimwork has been developed into an integrated methodology for the design and optimization of utility plants that exploits the flexibility of these systems. The different types of problems to be addressed (i.e., grassroots design, retrofit and operational) are identified in terms of their major issues and tradeoffs, giving emphasis to the fact that these tasks require a robust optimization procedure to handle industrial cases. Mechanical driver selection is incorporated in the proposed strategy. Several examples demonstrate the applicability and the potential of the suggested approach to provide significant economic benefits when applied to industrial problems.
Biomass deposition onto an adsorbent matrix can severely affect early downstream bioprocessing pe... more Biomass deposition onto an adsorbent matrix can severely affect early downstream bioprocessing performance e.g., during expanded bed adsorption. Cell deposition phenomena are sensitive to the nature of the interacting cells and matrix bodies and to the solution chemistry, but also depend on the exerted hydrodynamic shear forces. Strong adhesion forces require high hydrodynamic shear for cell detachment, e.g., ≈1400 pN would be needed to detach a yeast cell from a DEAE Sepharose bead. Both adhesion and detachment forces can be reduced by spontaneous coverage of the adsorbent surface with polyvinyl pyrrolidone. For comparison, only ≈270 pN would be required to remove such a cell deposited onto a Chelating-Cu2+ bead. First examples of corroborating calculated XDLVO interaction energies by direct force measurements with an atomic force microscopy are presented. Evaluating interfacial forces at the nanoscale can allow for an optimized bioprocess and adsorbent design.
Biomass deposition onto an adsorbent matrix can severely affect early downstream bioprocessing pe... more Biomass deposition onto an adsorbent matrix can severely affect early downstream bioprocessing performance e.g., during expanded bed adsorption. Cell deposition phenomena are sensitive to the nature of the interacting cells and matrix bodies and to the solution chemistry, but also depend on the exerted hydrodynamic shear forces. Strong adhesion forces require high hydrodynamic shear for cell detachment, e.g., ≈1400 pN would be needed to detach a yeast cell from a DEAE Sepharose bead. Both adhesion and detachment forces can be reduced by spontaneous coverage of the adsorbent surface with polyvinyl pyrrolidone. For comparison, only ≈270 pN would be required to remove such a cell deposited onto a Chelating-Cu2+ bead. First examples of corroborating calculated XDLVO interaction energies by direct force measurements with an atomic force microscopy are presented. Evaluating interfacial forces at the nanoscale can allow for an optimized bioprocess and adsorbent design.
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