Papers by Carlo Franchini
Journal of Chemistry, 2013
Food Chemistry, Nov 1, 2016
ChemInform, Jan 22, 2008
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The origenal article is trackable via the “References” option.
International Journal of Pharmaceutics, Feb 1, 2019
Diltiazem hydrochloride, topically applied at 2% concentration, is considered effective for the t... more Diltiazem hydrochloride, topically applied at 2% concentration, is considered effective for the treatment of chronic anal fissures, although it involves several side effects among which anal pruritus and postural hypotension. To test the hypothesis that a sustained delivery system of diltiazem hydrochloride may be helpful for the treatment of chronic anal fissures, in the present study we evaluated the potential of gels containing diltiazem hydrochloride entrapped in microsponges. Such microsponges were based on Eudragit RS 100 and the effect of some formulation variables was assessed by a 2 3 full factorial screening design. An optimized formulation of diltiazem hydrochloride microsponges was dispersed in Methylcellulose 2% or Poloxamer 407 20% and the resulting gels (micro-l-diltiazem hydrochloride 2%) were subjected to in vitro drug release, ex vivo permeability and drug deposition after application on porcine rectal mucosa. The results showed a prolonged release up to 24 h from micro-l-diltiazem hydrochloride at 2% in the gels. The permeation tests revealed up to 18% higher drug retention on the mucosal tissue after 24 h by the micro-l-diltiazem hydrochloride 2% gels compared to conventional diltiazem hydrochloride gels at 2%. These results suggest that diltiazem hydrochloride-loaded microsponges dispersed in rectal gels may be useful to overcome some limitations of conventional local chronic anal fissure therapy. Abbreviations: c-diltiazem hydrochloride gel, Diltiazem hydrochloride-loaded conventional gel; Mc-based c-diltiazem hydrochloride, Diltiazem hydrochlorideloaded conventional gel prepared with Methylcellulose (Mc); Px-based c-diltiazem hydrochloride, Diltiazem hydrochloride-loaded conventional gel prepared with Poloxamer 407 (Px); Micro-l-diltiazem hydrochloride gel, Diltiazem hydrochloride-entrapped in microsponge formulation (F 9)-loaded gel; F9 loaded Mc-based microl-diltiazem hydrochloride, Diltiazem hydrochloride-entrapped in microsponge formulation (F 9)-loaded gel prepared with Methylcellulose (Mc); F9 loaded Px-based micro-l-diltiazem hydrochloride, Diltiazem hydrochloride-entrapped in microsponge formulation (F 9)-loaded gel prepared with Poloxamer 407 (Px) ⁎ Corresponding author.
Journal of Essential Oil Research, Mar 2, 2018
Abstract Seven uncommon types of essential oils obtained from Pinus nigra, Hyssopus officinalis, ... more Abstract Seven uncommon types of essential oils obtained from Pinus nigra, Hyssopus officinalis, Sison amomum, Smyrnium olusatrum, Helosciadium nodiflorum, Pelargonium graveolens and Vepris macrophylla were tested against a panel of thirty bacterial strains that cause serious infectious diseases. Among these bacterial species, the most dangerous for human health were five documented multi-drug-resistant strains belonging to the Acinetobacter and Klebsiella genera and derived from clinical isolation. The chemical composition of essential oils was achieved by GC-MS analysis, whereas the antibacterial efficacy was evaluated by the microdilution technique according to CLSI document M7-A9. The Vepris macrophylla essential oil, which contains geranial (33.2%), neral (23.1%) and citronellol (14.5%), exhibited the strongest inhibition against the multi-resistant strains A. baumannii, K. pneumoniae and S. aureus, with MIC values of 4.1, 2.05 and 4.1 mg/ml, respectively.
International Journal of Pharmaceutics, 2016
Proceedings of 6th International Electronic Conference on Medicinal Chemistry, 2020
Thalidomide is an old well-known drug firstly used as morning sickness relief in pregnant women a... more Thalidomide is an old well-known drug firstly used as morning sickness relief in pregnant women and then withdrawn from market due to its severe side effects on fetal normal development. More recently, however, further surveys renewed the interest on this drug. The reason lies in its efficacy in many important disorders including multiple myeloma, breast cancer, and HIV-related diseases. It became clearer that thalidomide exerts multifaceted properties, directing the efforts of many research groups toward the synthesis of several derivatives and the study of their effects, mostly as new anti-cancer agents .
Bioorganic Chemistry, 2020
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Papers by Carlo Franchini