Overview

Title

Draft NIOSH Skin Notation Profile: Phenothiazine

Subject

An assessment of the available scientific information on the dermal hazard of this workplace chemical.

Purpose

To provide scientific information about the dermal hazard and NIOSH skin notation associated with this workplace chemical.

Review information

Charge to peer reviewers

1. Does this document clearly outline the systemic health hazards associated with exposures of the skin to the chemical?
   1. If not, what specific information is missing from the document?
2. If the SYS or SYS (FATAL) notations are assigned, are the rationale and logic behind the assignment clear?
   1. If not assigned, is the logic clear why it was not (e.g., insufficient data, no identified health hazard)?
   2. If not clear, what clarification is suggested?
3. Does this document clearly outline the direct (localized) health hazards associated with exposures of the skin to the chemical?
   1. If not, what specific information is missing from the document?
4. If the DIR, DIR (IRR), or DIR (COR) notations are assigned, are the rationale and logic behind the assignment clear?
   1. If not assigned, is the logic clear why it was not (e.g., insufficient data, no identified health hazard)?
   2. If not clear, what clarification is suggested?
5. Does this document clearly outline the immune-mediated responses (allergic response) associated with exposures of the skin to the chemical?
   1. If not, what specific information is missing from the document?
6. If the SEN notation is assigned, are the rationale and logic behind the assignment clear?
   1. If not assigned, is the logic clear why it was not assigned (e.g., insufficient data, no identified health hazard)?
   2. If not clear, what clarification is suggested?
7. If the ID (SK) or SK were assigned, are the rationale and logic outlined clearly within the document?
   1. If not clear, what clarification is suggested?
8. Are the conclusions supported by the data?
   1. If not, what changes are suggested?
9. Are the tables clear and appropriate?
   1. If not, what changes are suggested?
10. Are you aware of any scientific data reported in governmental publications, databases, peer-reviewed journals, or other sources that should be considered within this document?
    1. Please include the full reference citation for any additional scientific data to be considered.
11. There have been considerable improvements and advancements in dermal absorption studies and modeling since the publication of NIOSH Current Intelligence Bulletin 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2017]. In response to expert external peer reviewers' comments regarding the limitation of the skin to inhalation dose (SI) ratio information, the SI ratio was removed from the individual skin notation profile documents.
    1. Do you have any information to support removing or including the SI ratio information in these NIOSH documents?