DHEA is a precursor steroid which gives rise to the sex steroids as well as etiocholanolone which... more DHEA is a precursor steroid which gives rise to the sex steroids as well as etiocholanolone which have profound effects on a wide variety of physiologic or pathophysiologic events. DHEA modulates diabetes, obesity, carcinogenesis, tumor growth, neurite outgrowth, virus and bacterial infection, stress, pregnancy, hypertension, collagen and skin integrity, fatigue, depression, memory and immune responses. In the past, we ascribed this action to DHEA's role in "state dependency" and likened its action to "buffer hormones" in an effort to explain the multiple physiologic effects of this single hormone (1). "State dependency" explains the varied action of a hormone based upon the expression of its action only within particular physiologic settings. Examples of "state-dependent" action or "buffer hormones" with widely varied physiologic effects, other than DHEA, are thyroid or thyrotropin releasing hormones (TRH) and melatonin. Their action affects widely divergent systems, depending on physiologic state, i.e., shock, immune status, circadian or seasonal rhythms. In this regard, DHEA is perhaps our best example of a "buffer steroid" as it appears to work in widely divergent systems against a variety of targets, depending on Dehydroepiandrosterone (DHEA)
It seems the ‘form ’ of silver used has bearing on it’s effectiveness and occurrence of side-effe... more It seems the ‘form ’ of silver used has bearing on it’s effectiveness and occurrence of side-effects. One of the most effective anti-microbial therapies available to wholistic health practitioners today is Mild Silver Protein (MSP). Silver use as an antibiotic is not new. It has a long history and it has undergone resurgence of late. Even if you are not familiar with colloidal silver, you can be sure some of your patients are already using it. This article is about information you need to be aware of as their doctor. All silver products are not created equal and its effectiveness varies considerably. Unfortunately, there is a lot of hype that has gone into the marketing of silver products. They include statements like: No one knows why silver is so lethal to pathogenic organisms. “No known pathogenic virus or bacterium has been able to develop immunity to silver. Silver is not toxic to higher life forms and specifically in our case, humans. This misinformation may hurt consumers and...
Forskolin acts primarily by activating the enzyme adenylate cyclase, which results in increased c... more Forskolin acts primarily by activating the enzyme adenylate cyclase, which results in increased cyclic adenosine monophosphate (cAMP) in cells. Cyclic AMP belongs to a class of substances known as "second messengers" and is one of the most important cell-regulating compounds. Among its many roles, cAMP activates numerous other enzymes involved in diverse cellular functions. Hormones and neurotransmitters also activate adenylate cyclase, but Forskolin appears to be able to activate adenylate cyclase by itself. Thus, Forskolin can increase cyclic AMP without the assistance of hormones or neurotransmitters.
The most common type of cataract – a nuclear cataract – is characterized by a cloudy haze inside ... more The most common type of cataract – a nuclear cataract – is characterized by a cloudy haze inside the lens (Fig. 1). This haze is the physical manifestation of a random clumping together of the once beautifully ordered arrangement of lens proteins called crystallins. As the cataract develops in size and density, it reduces the amount of light that passes through the lens and scatters the light that does get through. Thus, instead of all the light rays being focused precisely to a point on the retina, forming a sharp, clear image of what we are seeing, many of the rays are spread out across the retina, forming a fuzzy image. Colors may be dulled or distorted, and there may be an annoying halo of light around bright objects, causing a glare effect.
Carnosine (beta-alanyl-L-histidine) (Fig. 1) is a naturally-occurring dipeptide composed of two a... more Carnosine (beta-alanyl-L-histidine) (Fig. 1) is a naturally-occurring dipeptide composed of two amino acids alanine and histidine. While the majority of early research on carnosine was conducted in Russia following its discovery in 1900, Western scientists have recently begun to recognize the tremendous range of health benefits supported by this highly effective anti-aging nutrient. Carnosine Declines with Age Carnosine (not to be confused with L-carnitine) is found in highest concentrations in long-lived tissues such as skeletal muscle, cardiac muscle and brain.1 Muscle carnosine levels in humans decline 63 percent from age 10 to 70 (Fig. 2).2 This marked reduction in muscle carnosine concentration may be a cause of the age-related decline in muscle mass, strength and function. Stress, infections and trauma also cause carnosine levels to decline, which may help explain the increased mortality in the elderly following stressful events. Carnosines Multiple Anti-Aging Mechanisms The metabolic pathway shown in (Fig. 3) illustrates how carnosine participates in several important biological reactions, including methylation (giving rise to anserine or ophidine), hydrolysis (leading to histidine and beta-alanine), and decarboxylation (resulting in histamine formation, which interacts with beta-alanine to result in the formation of carnicine). Carnicine, a stable analog of carnosine, has been used experimentally to reverse cataracts. Carnosines two amino acids, histidine and alanine, are metabolized in the citric acid cycle. Alanine enters through the Coenzyme A pathway and histidine through the alpha-ketoglutarate pathway. Aging is associated with damage to cellular proteins, resulting in inter-and intra-molecular cross-linking. Carnosine protects cellular proteins from such metabolic damage in at least two ways. First, as an antioxidant, carnosine prevents the formation of oxidized sugars, or glycosyl radicals, also called advanced glycosylation end products (AGEs).3 Second, carnosine bonds with potentially harmful carbonyl groups that attack and bind with proteins imbedded in the cellular membrane, and neutralizes them. Both of these processes have important implications for anti-aging therapy, in that carnosine not only prevents damaging crosslinks from forming, it eliminates cross-links that have previously formed, thus restoring normal membrane function.4 Carnosine also has the remarkable ability to down-regulate cellular and enzymatic processes when in excess, and upregulate them when suppressed. For example, carnosine decreases platelet aggregation in patients with abnormal clotting tendencies (thins the blood), and increases platelet aggregation in patients with low clotting indices.5 Closely related to this auto-regulation ability are carnosines effects as an anti-inflammatory and immunoregulatory nutrient. Carnosine suppresses Print | Close Window
Abstract : Thirty one papers are grouped in three sections: advances in adaptations to heat, adva... more Abstract : Thirty one papers are grouped in three sections: advances in adaptations to heat, advances in adaptations to altitude, and advances in biology of aging.
DHEA is a precursor steroid which gives rise to the sex steroids as well as etiocholanolone which... more DHEA is a precursor steroid which gives rise to the sex steroids as well as etiocholanolone which have profound effects on a wide variety of physiologic or pathophysiologic events. DHEA modulates diabetes, obesity, carcinogenesis, tumor growth, neurite outgrowth, virus and bacterial infection, stress, pregnancy, hypertension, collagen and skin integrity, fatigue, depression, memory and immune responses. In the past, we ascribed this action to DHEA's role in "state dependency" and likened its action to "buffer hormones" in an effort to explain the multiple physiologic effects of this single hormone (1). "State dependency" explains the varied action of a hormone based upon the expression of its action only within particular physiologic settings. Examples of "state-dependent" action or "buffer hormones" with widely varied physiologic effects, other than DHEA, are thyroid or thyrotropin releasing hormones (TRH) and melatonin. Their action affects widely divergent systems, depending on physiologic state, i.e., shock, immune status, circadian or seasonal rhythms. In this regard, DHEA is perhaps our best example of a "buffer steroid" as it appears to work in widely divergent systems against a variety of targets, depending on Dehydroepiandrosterone (DHEA)
It seems the ‘form ’ of silver used has bearing on it’s effectiveness and occurrence of side-effe... more It seems the ‘form ’ of silver used has bearing on it’s effectiveness and occurrence of side-effects. One of the most effective anti-microbial therapies available to wholistic health practitioners today is Mild Silver Protein (MSP). Silver use as an antibiotic is not new. It has a long history and it has undergone resurgence of late. Even if you are not familiar with colloidal silver, you can be sure some of your patients are already using it. This article is about information you need to be aware of as their doctor. All silver products are not created equal and its effectiveness varies considerably. Unfortunately, there is a lot of hype that has gone into the marketing of silver products. They include statements like: No one knows why silver is so lethal to pathogenic organisms. “No known pathogenic virus or bacterium has been able to develop immunity to silver. Silver is not toxic to higher life forms and specifically in our case, humans. This misinformation may hurt consumers and...
Forskolin acts primarily by activating the enzyme adenylate cyclase, which results in increased c... more Forskolin acts primarily by activating the enzyme adenylate cyclase, which results in increased cyclic adenosine monophosphate (cAMP) in cells. Cyclic AMP belongs to a class of substances known as "second messengers" and is one of the most important cell-regulating compounds. Among its many roles, cAMP activates numerous other enzymes involved in diverse cellular functions. Hormones and neurotransmitters also activate adenylate cyclase, but Forskolin appears to be able to activate adenylate cyclase by itself. Thus, Forskolin can increase cyclic AMP without the assistance of hormones or neurotransmitters.
The most common type of cataract – a nuclear cataract – is characterized by a cloudy haze inside ... more The most common type of cataract – a nuclear cataract – is characterized by a cloudy haze inside the lens (Fig. 1). This haze is the physical manifestation of a random clumping together of the once beautifully ordered arrangement of lens proteins called crystallins. As the cataract develops in size and density, it reduces the amount of light that passes through the lens and scatters the light that does get through. Thus, instead of all the light rays being focused precisely to a point on the retina, forming a sharp, clear image of what we are seeing, many of the rays are spread out across the retina, forming a fuzzy image. Colors may be dulled or distorted, and there may be an annoying halo of light around bright objects, causing a glare effect.
Carnosine (beta-alanyl-L-histidine) (Fig. 1) is a naturally-occurring dipeptide composed of two a... more Carnosine (beta-alanyl-L-histidine) (Fig. 1) is a naturally-occurring dipeptide composed of two amino acids alanine and histidine. While the majority of early research on carnosine was conducted in Russia following its discovery in 1900, Western scientists have recently begun to recognize the tremendous range of health benefits supported by this highly effective anti-aging nutrient. Carnosine Declines with Age Carnosine (not to be confused with L-carnitine) is found in highest concentrations in long-lived tissues such as skeletal muscle, cardiac muscle and brain.1 Muscle carnosine levels in humans decline 63 percent from age 10 to 70 (Fig. 2).2 This marked reduction in muscle carnosine concentration may be a cause of the age-related decline in muscle mass, strength and function. Stress, infections and trauma also cause carnosine levels to decline, which may help explain the increased mortality in the elderly following stressful events. Carnosines Multiple Anti-Aging Mechanisms The metabolic pathway shown in (Fig. 3) illustrates how carnosine participates in several important biological reactions, including methylation (giving rise to anserine or ophidine), hydrolysis (leading to histidine and beta-alanine), and decarboxylation (resulting in histamine formation, which interacts with beta-alanine to result in the formation of carnicine). Carnicine, a stable analog of carnosine, has been used experimentally to reverse cataracts. Carnosines two amino acids, histidine and alanine, are metabolized in the citric acid cycle. Alanine enters through the Coenzyme A pathway and histidine through the alpha-ketoglutarate pathway. Aging is associated with damage to cellular proteins, resulting in inter-and intra-molecular cross-linking. Carnosine protects cellular proteins from such metabolic damage in at least two ways. First, as an antioxidant, carnosine prevents the formation of oxidized sugars, or glycosyl radicals, also called advanced glycosylation end products (AGEs).3 Second, carnosine bonds with potentially harmful carbonyl groups that attack and bind with proteins imbedded in the cellular membrane, and neutralizes them. Both of these processes have important implications for anti-aging therapy, in that carnosine not only prevents damaging crosslinks from forming, it eliminates cross-links that have previously formed, thus restoring normal membrane function.4 Carnosine also has the remarkable ability to down-regulate cellular and enzymatic processes when in excess, and upregulate them when suppressed. For example, carnosine decreases platelet aggregation in patients with abnormal clotting tendencies (thins the blood), and increases platelet aggregation in patients with low clotting indices.5 Closely related to this auto-regulation ability are carnosines effects as an anti-inflammatory and immunoregulatory nutrient. Carnosine suppresses Print | Close Window
Abstract : Thirty one papers are grouped in three sections: advances in adaptations to heat, adva... more Abstract : Thirty one papers are grouped in three sections: advances in adaptations to heat, advances in adaptations to altitude, and advances in biology of aging.
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Papers by Ward Dean