As the primary office that clears official, unclassified DoD information for public release on behalf of the Secretary of Defense, DOPSR receives requests directly for DoD security and policy review and public release approval of DoD information from organizations across the Executive Branch. Examples include the White House Office of Science and Technology, Central Intelligence Agency, Federal Bureau of Investigation, the Office of the Director of National Intelligence, NASA, the Department of State, and the Department of Homeland Security.

In addition, DOPSR acts as the sole DoD liaison to the Inter-agency Security Classification Appeals Panel (ISCAP) that provides the citizenry and users of the classification system with a forum for further review of previous declassification review decisions.