ICI-118,551

ICI-118,551
	3-(izopropilamino)-1-[(7-metil-4-indanil)oksi]butan-2-ol
Identifikacija
CAS registarski broj	72795-19-8
PubChem	3682
MeSH	ICI+118551
ChEMBL	CHEMBL513389
Jmol-3D slike	Slika 1
SMILES
	CC1=C2CCCC2=C(C=C1)OCC(C(C)NC(C)C)O
InChI
	InChI=1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3 ; Kod: VFIDUCMKNJIJTO-UHFFFAOYSA-N
Svojstva
Molekulska formula	C17H27NO2
Molarna masa	277,402 g/mol
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

ICI-118,551 je selektivni antagonist beta-2 (β₂) adrenergičkog receptora.^[4]^[5] ICI se vezuje za β₂ receptor sa više od sto puta većim afinitetom nego za β₁ ili β₃ receptor.^[6]^[7] Kompanija Imperijalne hemijske industrije je razvila ovo jedinjenje.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Hillman KL, Doze VA, Porter JE (August 2005). „Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus”. The Journal of Pharmacology and Experimental Therapeutics 314 (2): 561–7. DOI:10.1124/jpet.105.084947. PMID 15908513.
↑ Summerhill S, Stroud T, Nagendra R, Perros-Huguet C, Trevethick M (2008). „A cell-based assay to assess the persistence of action of agonists acting at recombinant human beta(2) adrenoceptors”. Journal of Pharmacological and Toxicological Methods 58 (3): 189–97. DOI:10.1016/j.vascn.2008.06.003. PMID 18652905.
↑ Mauriège P, De Pergola G, Berlan M, Lafontan M (May 1988). „Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta-1 antagonists”. Journal of Lipid Research 29 (5): 587–601. PMID 2900871. ^{[mrtav link]}
↑ Emorine LJ, Marullo S, Briend-Sutren MM, et al. (September 1989). „Molecular characterization of the human beta 3-adrenergic receptor”. Science 245 (4922): 1118–21. DOI:10.1126/science.2570461. PMID 2570461.

Vanjske veze

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid15908513-4] Hillman KL, Doze VA, Porter JE (August 2005). „Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus”. The Journal of Pharmacology and Experimental Therapeutics 314 (2): 561–7. DOI:10.1124/jpet.105.084947. PMID 15908513.

[pmid18652905-5] Summerhill S, Stroud T, Nagendra R, Perros-Huguet C, Trevethick M (2008). „A cell-based assay to assess the persistence of action of agonists acting at recombinant human beta(2) adrenoceptors”. Journal of Pharmacological and Toxicological Methods 58 (3): 189–97. DOI:10.1016/j.vascn.2008.06.003. PMID 18652905.

[pmid2900871-6] Mauriège P, De Pergola G, Berlan M, Lafontan M (May 1988). „Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta-1 antagonists”. Journal of Lipid Research 29 (5): 587–601. PMID 2900871. ^{[mrtav link]}

[pmid2570461-7] Emorine LJ, Marullo S, Briend-Sutren MM, et al. (September 1989). „Molecular characterization of the human beta 3-adrenergic receptor”. Science 245 (4922): 1118–21. DOI:10.1126/science.2570461. PMID 2570461.

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ICI-118,551

Reference

Vanjske veze

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