This Perspective discusses current knowledge of the diverse roles played by different macrophage populations within the Mycobacterium tuberculosis-infected lung. The underlying hypothesis is that disease outcome depends on macrophage ontogeny and epigenetic programming, in addition to the immune environment.

This Review summarizes mechanisms for the regulation of cGAS–STING signalling, describes its crosstalk with other signalling pathways, and outlines the diverse cellular outcomes of cGAS–STING biology and its roles in inflammatory disease, ageing and tumorigenesis.

This Review discusses recent advances in our understanding of the biology of endogenous tissue regeneration in the thymus, highlighting the clinical implications of poor thymic recovery.

Here the authors describe the different ways that cancer cells evade the immune system and how these mechanisms impact immunoediting and tumour clonality. They suggest that in tumours that become highly heterogeneous, presentation of subclonal antigens can result in immune evasion and may explain their poor prognosis and response to immunotherapy.