PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Compute standard Non-Compartmental Analysis (NCA) parameters for typical pharmacokinetic analyses and summarize them.

Version:	0.11.0
Imports:	checkmate, dplyr (≥ 0.5.0), digest, nlme, purrr, rlang, stats, tidyr, tibble, utils, lifecycle
Suggests:	covr, cowplot, ggplot2, knitr, labeling, pander, pmxTools, rmarkdown, spelling, testthat (≥ 3.0.0), units, withr
Published:	2024-06-19
DOI:	10.32614/CRAN.package.PKNCA
Author:	Bill Denney [aut, cre], Clare Buckeridge [aut], Sridhar Duvvuri [ctb]
Maintainer:	Bill Denney <wdenney at humanpredictions.com>
BugReports:	https://github.com/billdenney/pknca/issues
License:	AGPL-3
URL:	https://billdenney.github.io/pknca/, https://github.com/billdenney/pknca, http://billdenney.github.io/pknca/
NeedsCompilation:	no
Language:	en-US
Citation:	PKNCA citation info
Materials:	README NEWS
In views:	MixedModels, Pharmacokinetics
CRAN checks:	PKNCA results

Documentation:

Reference manual:

PKNCA.pdf

Vignettes:

Introduction to PKNCA and Usage Instructions (source, R code) Computing NCA Parameters for Theophylline (source, R code) Selection of Calculation Intervals (source, R code) Sparse NCA Calculations (source, R code) AUC Calculation with PKNCA (source, R code) Half-life calculation with Tobit regression (source, R code) Half-Life Calculation (source, R code) Post-Processing (source, R code) Unit Assignment and Conversion with PKNCA (source, R code) Data Imputation (source, R code) Superposition of Pharmacokinetic Data (source, R code) Methods Used for Dose-Aware Concentration Interpolation/Extrapolation (source, R code) Noncompartmental evaluation of time to steady-state (source, R code) AUC integration methods (source, R code) PKNCA Training Sessions (source, R code) Options for Controlling PKNCA (source, R code) PKNCA Validation (source, R code) Writing PKNCA Parameter Functions (source, R code)

Downloads:

Package source:	PKNCA_0.11.0.tar.gz
Windows binaries:	r-devel: PKNCA_0.11.0.zip, r-release: PKNCA_0.11.0.zip, r-oldrel: PKNCA_0.11.0.zip
macOS binaries:	r-release (arm64): PKNCA_0.11.0.tgz, r-oldrel (arm64): PKNCA_0.11.0.tgz, r-release (x86_64): PKNCA_0.11.0.tgz, r-oldrel (x86_64): PKNCA_0.11.0.tgz
Old sources:	PKNCA archive

Reverse dependencies:

Reverse imports:	mbbe, pmxTools, ruminate, ubiquity
Reverse suggests:	babelmixr2

Linking:

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