gsDesign: Group Sequential Design

Derives group sequential clinical trial designs and describes their properties. Particular focus on time-to-event, binary, and continuous outcomes. Largely based on methods described in Jennison, Christopher and Turnbull, Bruce W., 2000, "Group Sequential Methods with Applications to Clinical Trials" ISBN: 0-8493-0316-8.

Version: 3.6.5
Depends: R (≥ 3.5.0)
Imports: dplyr (≥ 1.1.0), ggplot2 (≥ 3.1.1), graphics, gt, magrittr, methods, r2rtf, rlang, stats, tibble, tidyr, tools, xtable
Suggests: covr, data.table, gridExtra, kableExtra, knitr, mvtnorm, ragg, rmarkdown, scales, testthat, utils
Published: 2024-11-14
DOI: 10.32614/CRAN.package.gsDesign
Author: Keaven Anderson [aut, cre], Merck & Co., Inc., Rahway, NJ, USA and its affiliates [cph]
Maintainer: Keaven Anderson <keaven_anderson at merck.com>
BugReports: https://github.com/keaven/gsDesign/issues
License: GPL (≥ 3)
URL: https://keaven.github.io/gsDesign/, https://github.com/keaven/gsDesign
NeedsCompilation: yes
Materials: README NEWS
In views: ExperimentalDesign
CRAN checks: gsDesign results

Documentation:

Reference manual: gsDesign.pdf
Vignettes: Conditional error spending functions (source, R code)
Conditional power and conditional error (source, R code)
A gentle introduction to group sequential design (source, R code)
Graphical testing for group sequential design (source)
A cure model calendar-based design (source, R code)
Spending function overview (source, R code)
Overview of survival endpoint design (source, R code)
Vaccine efficacy trial design (source, R code)
Binomial SPRT (source, R code)
gsDesign package overview (source, R code)
Basic time-to-event group sequential design using gsSurv (source, R code)
Multiplicity graphs (source)
Two-sample normal sample size (source, R code)
Integer sample size and event counts (source, R code)

Downloads:

Package source: gsDesign_3.6.5.tar.gz
Windows binaries: r-devel: gsDesign_3.6.5.zip, r-release: gsDesign_3.6.5.zip, r-oldrel: gsDesign_3.6.5.zip
macOS binaries: r-release (arm64): gsDesign_3.6.5.tgz, r-oldrel (arm64): gsDesign_3.6.5.tgz, r-release (x86_64): gsDesign_3.6.5.tgz, r-oldrel (x86_64): gsDesign_3.6.5.tgz
Old sources: gsDesign archive

Reverse dependencies:

Reverse depends: gsbDesign
Reverse imports: BayesOrdDesign, gsDesign2, randomizeR
Reverse suggests: ADCT, BinGSD, gMCPLite, gscounts, ph2bye, ph2mult, RTSA, simtrial

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