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A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Cell cycle re-entry requires the growth factor-stimulation of at least two distinct classes of protein kinases: (i) the p42/p44 MAP kinases activated by the Ras>Raf>MKK cascade and (ii) the G1 cyclin-dependent protein kinases (CDKs). Specific inactivation of either class of kinase arrests fibroblasts in G1. Growth factors promote nuclear translocation and persistent activation of p42/p44 MAP kinases during the entire G0/G1 period. Here, we demonstrate that induction of cyclin D1, and therefore cdk4/6 activity associated with, is positively controlled by the p42/p44 MAP kinase cascade whereas the parallel cytokines/stress-activated p38MAP kinase cascade is antagonistic. Finally, using an antisense approach we demonstrate that p27Kip1 plays a key role in setting the growth factor-dependency of the GO state.

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Author information

Authors and Affiliations

  1. Centre de Biochimie-CNRS, Université de Nice, Parc Valrose, 06108, Nice, France

    Josée N. Lavoie, Nathalie Rivard, Gilles L’Allemain & Jacques Pouysségur

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  1. Josée N. Lavoie
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  2. Nathalie Rivard
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  3. Gilles L’Allemain
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  4. Jacques Pouysségur
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer , Silvana Guidet  & Lee Vogel ,  & 

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© 1996 Springer Science+Business Media New York

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Lavoie, J.N., Rivard, N., L’Allemain, G., Pouysségur, J. (1996). A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry. In: Meijer, L., Guidet, S., Vogel, L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5873-6_5

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  • DOI: https://doi.org/10.1007/978-1-4615-5873-6_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7693-4

  • Online ISBN: 978-1-4615-5873-6

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