Summary
Rats were trained to respond for water rewards on different bars in a Skinner box depending on whether they had previously been injected with nicotine or with saline. No other drug tested could consistently elicit responses on the “nicotine correct” bar. Pre-treatment with mecamylamine abolished the rats' ability to distinguish between nicotine and saline but pretreatment with chlorisondamine did not.
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Morrison, C.F., Stephenson, J.A. Nicotine injections as the conditioned stimulus in discrimination learning. Psychopharmacologia 15, 351–360 (1969). https://doi.org/10.1007/BF00403710
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DOI: https://doi.org/10.1007/BF00403710