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IP3 receptor signaling and endothelial barrier function

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Abstract

The endothelium, a monolayer of endothelial cells lining vessel walls, maintains tissue-fluid homeostasis by restricting the passage of the plasma proteins and blood cells into the interstitium. The ion Ca2+, a ubiquitous secondary messenger, initiates signal transduction events in endothelial cells that is critical to control of vascular tone and endothelial permeability. The ion Ca2+ is stored inside the intracellular organelles and released into the cytosol in response to environmental cues. The inositol 1,4,5-trisphosphate (IP3) messenger facilitates Ca2+ release through IP3 receptors which are Ca2+-selective intracellular channels located within the membrane of the endoplasmic reticulum. Binding of IP3 to the IP3Rs initiates assembly of IP3R clusters, a key event responsible for amplification of Ca2+ signals in endothelial cells. This review discusses emerging concepts related to architecture and dynamics of IP3R clusters, and their specific role in propagation of Ca2+ signals in endothelial cells.

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Modified from Fan et al. [133] with permission of the publisher. Copyright ©2015, Nature Publishing Group

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  1. Department of Pharmacology and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL, 60612, USA

    Mitchell Y. Sun, Melissa Geyer & Yulia A. Komarova

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  1. Mitchell Y. Sun
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  2. Melissa Geyer
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  3. Yulia A. Komarova
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Correspondence to Yulia A. Komarova.

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Supported by NIH Grants R01 HL103922 to Y.A.K; AHA AWARD 13PRE17090090 to M.G.

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The authors declare that they have no competing interests.

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Sun, M.Y., Geyer, M. & Komarova, Y.A. IP3 receptor signaling and endothelial barrier function. Cell. Mol. Life Sci. 74, 4189–4207 (2017). https://doi.org/10.1007/s00018-017-2624-8

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  • DOI: https://doi.org/10.1007/s00018-017-2624-8

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