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A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

Nature volume 346, pages 245–250 (1990)Cite this article

Abstract

A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.

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Author notes

  1. Peter Goodfellow: Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX, UK

Authors and Affiliations

  1. Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    John Gubbay, Jérôme Collignon, Peter Koopman, Blanche Capel, Androulla Economou, Andrea Münsterberg, Nigel Vivian, Peter Goodfellow & Robin Lovell-Badge

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  1. John Gubbay
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  2. Jérôme Collignon
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  3. Peter Koopman
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  4. Blanche Capel
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  5. Androulla Economou
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  6. Andrea Münsterberg
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  7. Nigel Vivian
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  8. Peter Goodfellow
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  9. Robin Lovell-Badge
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Gubbay, J., Collignon, J., Koopman, P. et al. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346, 245–250 (1990). https://doi.org/10.1038/346245a0

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