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Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1

Nature volume 379, pages 826–829 (1996)Cite this article

Abstract

THE process of learning involves stable changes in synaptic efficacy for which long-term potentiation (LTP)1 provides a widely adopted mammalian model. Synaptic modification induced by learning or LTP may involve the action of cell adhesion molecules2–4. One such candidate is the ubiquitous neuronal glycoprotein Thy-1 (refs 5, 6). In mice in which the gene encoding Thy-1 has been inactivated, we find a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus. Spatial learning by Thy-1-deficient mice, as assessed in the watermaze7, is unimpaired. Thus LTP in the cortical input to the dentate gyrus seems not to be required for spatial learning.

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References

  1. Bliss, T. V. P. & Collingridge, G. L. Nature 361, 31–39 (1993).

    Article  ADS  CAS  Google Scholar 

  2. Mayford, M., Barsilai, A., Keller, F., Schacher, S. & Kandel, E. R. Science 256, 638–644 (1992).

    Article  ADS  CAS  Google Scholar 

  3. Luthi, A., Laurent, J.-P., Figurov, A., Muller, D. & Schachner, M. Nature 372, 777–779 (1994).

    Article  ADS  Google Scholar 

  4. Fazeli, M. S., Breen, K., Errington, M. L. & Bliss, T. V. P. Neurosci. Lett. 169, 77–80 (1994).

    Article  CAS  Google Scholar 

  5. Morris, R. BioEssays 14, 715–722 (1992).

    Article  CAS  Google Scholar 

  6. Tiveron, M. C. et al. Nature 355, 745–748 (1992).

    Article  ADS  CAS  Google Scholar 

  7. Morris, R. G. M. Learn. Motivation 12, 239–260 (1981).

    Article  Google Scholar 

  8. Gordon, J. A., Silva, A., Morris, R., Tokugawa, Y. & Stryker, M. P. Soc. Neurosci. Abstr. 20, 203.5 (1994).

    Google Scholar 

  9. Wigstrom, H. & Gustafsson, B. Brain Res. 275, 153–158 (1983).

    Article  CAS  Google Scholar 

  10. Sloviter, R. S. & Brisman, J. L. J. Neurosci. 15, 811–820 (1995).

    Article  CAS  Google Scholar 

  11. Schenk, F. & Morris, R. G. M. Expl Brain Res. 58, 11–28 (1985).

    Article  CAS  Google Scholar 

  12. McNamara, R. K. & Skelton, R. W. Brain Res. Rev. 18, 33–49 (1993).

    Article  CAS  Google Scholar 

  13. Whishaw, I. Q. Behav. Brain Res. 24, 59–72 (1987).

    Article  CAS  Google Scholar 

  14. McNaughton, B. L., Barnes, C. A., Meltzer, J. & Sutherland, R. J. Expl Brain Res. 76, 485–96 (1989).

    Article  CAS  Google Scholar 

  15. Conrad, C. D. & Roy, E. J. J. Neurosci. 13, 2582–2590 (1993).

    Article  CAS  Google Scholar 

  16. Cho, Y. H. & Jaffard, R. Neurobiol. Learning Memory 64, 285–290 (1995).

    Article  CAS  Google Scholar 

  17. Silva, A. J., Stevens, C. F., Tonegawa, S. & Wang, Y. Science 257, 201–206 (1992).

    Article  ADS  CAS  Google Scholar 

  18. Silva, A. J., Paylor, R., Wehner, J. M. & Tonegawa, S. Science 257, 206–211 (1992).

    Article  ADS  CAS  Google Scholar 

  19. Abeliovich, A. et al. Cell 75, 1263–1271 (1993).

    Article  CAS  Google Scholar 

  20. Bach, M. E., Hawkins, R. D., Osman, M., Kandel, E. R. & Mayford, M. Cell 81, 905–915 (1995).

    Article  CAS  Google Scholar 

  21. Grant, S. G. N. et al. Science 258, 1903–1910 (1992).

    Article  ADS  CAS  Google Scholar 

  22. Bourtchuladze, R. et al. Cell 79, 59–68 (1994).

    Article  CAS  Google Scholar 

  23. Mayford, M., Abel, T. & Kandel, E. R. Curr. Opin. Neurobiol. 5, 141–148 (1995).

    Article  CAS  Google Scholar 

  24. Swanson, L. W., Kohler, C. & Bjorklund, A. in Handbook of Chemical Neuroanatomy. Vol. 5 Integrated systems of the CNS, Part I (eds Bjorklund, A., Hokfelt, T. & Swanson, L. W.) 125–277 (Elsevier, Amsterdam, 1987).

    Google Scholar 

  25. Forrest, D. et al. Neuron 13, 325–338 (1994).

    Article  CAS  Google Scholar 

  26. Ransom, R. W. & Stec, N. L. J. Neurochem. 51, 830–836 (1988).

    Article  CAS  Google Scholar 

  27. Halasy, K. & Somogyi, P. Eur. J. Neurosci. 5, 411–429 (1993).

    Article  CAS  Google Scholar 

  28. Naquet, P. et al. Immunol. Ser. 45, 99–117 (1989).

    CAS  PubMed  Google Scholar 

  29. Murphy, K. P. S. J., Williams, J. H., Bettache, N. & Bliss, T. V. P. Neuropharmacology 33, 1375–1385 (1994).

    Article  CAS  Google Scholar 

  30. Hanse, E. & Gustafsson, B. Eur. J. Neurosci. 4, 1191–1201 (1992).

    Article  Google Scholar 

Download references

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Author notes

  1. M. Nosten-Bertrand

    Present address: UMB C9923 au CNRS, Hôpital de la Pitié Salpêtrière, 75013, Paris, France

Authors and Affiliations

  1. Department of Neurobiology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    M. Nosten-Bertrand, E. Barboni, E. Kozlova & R. J. Morris

  2. Department of Neurophysiology, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    M. L. Errington, K. P. S. J. Murphy & T. V. P. Bliss

  3. Division of Molecular Medicine, North Shore University Hospital, Cornell University Medical College, New York, 11030, USA

    Y. Tokugawa & J. Silver

  4. Department of Human Biopathology, University of Rome 'La Sapienza', Rome, 00100, Italy

    E. Barboni

  5. Department of Cell Biology and Genetics, Erasmus University, Rotterdam, 3000DR, The Netherlands

    D. Michalovich

  6. Centre for Neuroscience, University of Edinburgh, Edinburgh, EH8 9LE, UK

    R. G. M. Morris

  7. Roche Institute of Molecular Biology, Nutley, New Jersey, 07110, USA

    C. L. Stewart

  8. Department of Experimental Pathology, UMDS Guy's Hospital, London Bridge, London, SE1 9RT, UK

    R. J. Morris

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Nosten-Bertrand, M., Errington, M., Murphy, K. et al. Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature 379, 826–829 (1996). https://doi.org/10.1038/379826a0

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