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Microbial Issues

CMV reactivation is associated with a lower incidence of relapse after allo-SCT for CML

Bone Marrow Transplantation volume 48, pages 1313–1316 (2013)Cite this article

Abstract

Preemptive therapy at CMV reactivation has diminished post-transplant CMV mortality. Furthermore, recent studies suggest a favorable ‘virus-versus-leukemia’ effect from reactivating CMV, reducing relapse of AML after SCT. We studied the relationship of CMV reactivation with leukemic relapse in 110 patients with CML receiving HLA-identical sibling SCT between 1993 and 2008. Of these, 79 (72%) were in chronic phase, 5 in second chronic phase, 17 in accelerated phase and 9 in blast phase. A total of 97 patients (88%) received a myeloablative conditioning regimen, 97 received 4-log ex vivo T cell-depleted grafts and 13 received T-replete grafts. CMV reactivation before day 100 was observed in 72 patients (65.5%). At a median follow-up of 6.2 years, CMV reactivation < day 100 as a time-dependent covariate was an independent factor associated with decreased relapse. We conclude that CMV reactivation may contribute to a beneficial GVL effect in CML transplant recipients.

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Acknowledgements

This research was supported by the Intramural Research Program of the National institutes of Health, at the National Heart, Lung, and Blood Institute.

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Authors and Affiliations

  1. Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    S Ito, P Pophali, E K Koklanaris, J Superata, R Childs, M Battiwalla & A J Barrett

  2. Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    Wu CO

  3. Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA

    G A Fahle

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  1. S Ito
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  2. P Pophali
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Correspondence to S Ito.

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Ito, S., Pophali, P., CO, W. et al. CMV reactivation is associated with a lower incidence of relapse after allo-SCT for CML. Bone Marrow Transplant 48, 1313–1316 (2013). https://doi.org/10.1038/bmt.2013.49

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