Abstract
The incidence of infertility and two or more spontaneous abortions was significantly increased in the parents, compared to that reported for the general population, in this pilot survey of 61 patients evaluated for major childhood psychoses. In addition, 18% of our patients had a history of early gestational exposure to progesterone/estrogen compounds (9 patients) and to cortisone (2 patients). This frequency of gestational hormonė exposure was significantly increased over that in normal infants from three published surveys. However, in 5 of the 11 patients with gestational hormonal exposure, the medication was prescribed because of prior parental reproductive problems or bleeding during the current pregnancy. Therefore, it cannot be concluded that the gestational hormonal exposure was causally related to the psychoses present in these patients. In order to obtain more conclusive data, there will need to be continued monitoring of parental reproductive histories and gestational environmental exposures in autistic and schizophrenic children.
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Rothman, K. J. Personal communication, March 18, 1980.
References
Aarskog, D. Maternal progestins as a possible cause of hypospadias.New England Journal of Medicine, 1979,300, 75–78.
American Psychiatric Association.Diagnostic and statistical manual of disorders (3rd ed.). Washington, D. C.: Author, 1980.
Funderburk, S. J., Guthrie, D., & Meldrum, D. Suboptimal pregnancy outcome among women with prior abortions and premature births.American Journal of Osbtetrics and Gynecology, 1976,126, 55–60.
Gill, W. B., Schumacher, G. F. B., & Bibbo, M. Structural and functional abnormalities in the sex organs of male offspring of mothers treated with diethylstilbestrol (DES).Journal of Reproductive Medicine, 1916,16, 147–153.
Goujard, J., & Rumeau-Rouquette, C. First-trimester exposure to progestagen/oestrogen and congenital malformations.Lancet, 1977,i, 482–483.
Heinonen, O. P., Slone, D., Monson, R. R., Hook, E. B., & Shapiro, S. Cardiovascular birth defects and antenatal exposure to female sex hormones.New England Journal of Medicine, 1977,296, 67–70.
Janerich, D. T., Dugan, J. M., Standfast, S. J., & Strite, L. Congenital heart disease and prenatal exposure to exogenous sex hormones.British Medical Journal, 1977,1, 1058–1060.
Janerich, D. T., Piper, J. M., & Glebatis, D. M. Oral contraceptives and congenital limb-reduction defects.New England Journal of Medicine, 1974,291, 697–700.
Niswander, K. R., & Gordon, M. Maternal characteristics. Section 3. Past obstetrical history. InWomen and their pregnancies. Washington, D.C.: United States Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, 1972. Pp. 154–206.
Nora, J. J., Nora, A. H., Blu, J., Ingram, J., Fountain, A., Peterson, M., Lortscher, R. H., Kimberling, W. J. Exogenous progestogen and estrogen implicated in birth defects.Journal of the American Medical Association, 1978,240, 837–843.
Ornitz, E. M. Childhood autism — A review of the clinical and experimental literature.California Medicine, 1973,118, 21–47.
Pasamanick, B., & Lilienfeld, A. Association of maternal and fetal factors with development of mental deficiency.Journal of the American Medical Association, 1955,159, 155–160.
Reinisch, J. M., Simon, N. G., Karow, W. G., & Gandelman, R. Prenatal exposure to prednisone in humans and animals retards intrauterine growth.Science, 1978,202, 436–438.
Rothman, K. J., Fyler, D. C., Goldblatt, A., & Kreidberg, M. B. Exogenous hormones and other drug exposures of children with congenital heart disease.American Journal of Epidemiology, 1979,109, 433–439.
Torrey, E., Hersh, S., & McCabe, K. Early childhood psychosis and bleeding during pregnancy. A prospective study of gravid women and their offspring.Journal of Autism and Childhood Schizophrenia, 1975,5, 287–297.
Wilson, J. G., & Brent, R. L. Are female sex hormones teratogenic?American Journal of Obstetrics and Gynecology, 1981,141, 567–570.
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This research was supported in part by the UCLA Mental Retardation/Child Psychiatry Division, by USPHS grant NCT-927, Maternal and Child Health Service, and by HD-04612, HD-05615, and HD-06576, National Institute of Child Health and Human Development. We are grateful to Linda Wake for psychological testing, to Debra Deitrich and Marcia Greensite for coordinating patient visits, and to Judith Hohl for assistance with preparation of the manuscript.
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Funderburk, S.J., Carter, J., Tanguay, P. et al. Parental reproductive problems and gestational hormonal exposure in autistic and schizophrenic children. J Autism Dev Disord 13, 325–332 (1983). https://doi.org/10.1007/BF01531570
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DOI: https://doi.org/10.1007/BF01531570