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The Changing Balance Between Osteoblastogenesis and Adipogenesis in Aging and its Impact on Hematopoiesis

  • Skeletal Biology (DB Burr, Section Editor)
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Abstract

Osteoblasts (OBs) and adipocytes (APs) share a common mesenchymal ancestor. It is now clear that mesenchymal stem cell (MSC) maturation along the OB lineage comes at the expense of adipogenesis and vice versa. During aging, this balance increasingly favors the formation of APs. Hematopoiesis also slowly declines during the aging process. The role of OB lineage cells in hematopoiesis has been studied, but less is known about how APs regulate hematopoiesis. A few studies have demonstrated a negative relationship between APs and hematopoiesis; however, there is also evidence that brown adipose tissue (BAT) may promote hematopoiesis. This review will examine the current knowledge of how adipogenesis and osteogenesis change with aging and the implications of this changing environment on hematopoeisis.

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Acknowledgements

Indiana University is an NIDDK designated Center of Excellence in Molecular Hematology (NIDDK P01 DK090948). M.B. is supported by an NHLBI training grant (T32 HL007910-13).

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M Bethel: NIH training grant; BR Chitteti: none; EF Srour: none; and MA Kacena: institution NIH grant.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Indiana University School of Medicine, 1120 South Drive, FH 115, Indianapolis, IN, 46202, USA

    Monique Bethel & Melissa A. Kacena

  2. Department of Medicine, Indiana University School of Medicine, 980 W. Walnut Street, R3-C356, Indianapolis, IN, 46202, USA

    Brahmananda R. Chitteti

  3. Departments of Medicine, Pediatrics, Microbiology and Immunology, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, 980 W. Walnut Street, R3-C312, Indianapolis, IN, 46202, USA

    Edward F. Srour

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  1. Monique Bethel
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  2. Brahmananda R. Chitteti
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  4. Melissa A. Kacena
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Correspondence to Melissa A. Kacena.

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Bethel, M., Chitteti, B.R., Srour, E.F. et al. The Changing Balance Between Osteoblastogenesis and Adipogenesis in Aging and its Impact on Hematopoiesis. Curr Osteoporos Rep 11, 99–106 (2013). https://doi.org/10.1007/s11914-013-0135-6

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