Li Lanjuan: Difference between revisions

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{{shortShort description|Chinese epidemiologist (born 1947)}}
{{Use dmy dates|date=February 2020}}
{{ChineseFamily name hatnote|[[Li (surname 李)|Li]]|lang=Chinese}}
{{short description|Chinese epidemiologist}}
{{Infobox scientistofficeholder
{{Chinese name|[[Li (surname 李)|Li]]}}
| name = Li Lanjuan
{{Infobox scientist
| name native_name = Li Lanjuan{{nobold|李兰娟}}
| native_name_lang = zh
| image = 李兰娟院士.jpg
| captionimage = Li in 2006 = 李兰娟院士.jpg
| caption = Li in 2006
| birth_date = {{birth date and age|df=yes|1947|09|13}}
| office = Director-general of the Health Department of Zhejiang Province
| birth_place = [[Shaoxing]], [[Zhejiang]], [[Republic of China (1912–1949)|Republic of China]]
| term_start = March 1998
| death_date = <!-- {{death date and age|df=yes|}} or {{death year and age| }}-->
| term_end = March 2008
| death_place =
| birth_date = {{birth date and age|df=yes|1947|09|13}}
| death_cause =
| birth_place = [[Shaoxing]], [[Zhejiang]], [[Republic of China (1912–1949)|Republic of China]]
| resting_place =
| death_date = <!-- {{death date and age|df=yes|}} or {{death year and age| }}-->
| resting_place_coordinates = <!--{{coord|LAT|LONG|type:landmark|display=it}}-->
| fieldsdeath_place = [[Epidemiology]]
| occupation = [[Epidemiologist]], [[hepatologist]]
| workplaces = First Affiliated Hospital of [[Zhejiang University]]
| alma_materparty = [[ZhejiangChinese MedicalCommunist UniversityParty]]
| alma_mater = [[Zhejiang Medical University]]
| spouse = {{ill|Zheng Shusen|zh|郑树森 (医学家)}}
| childrenspouse = 1[[Zheng sonShusen]]
| children = 1 son
| awards = [[State Science and Technology Progress Award]] (6 times)<br />[[Ho Leung Ho Lee Prize]] (2014)
| thesis_titlesignature = <!--(or | thesis1_title = and | thesis2_title =<!--(filename only)-->
| signature_alt =
| thesis_url = <!--(or | thesis1_url = and | thesis2_url = )-->
| awards = [[State Science and Technology Progress Award]] (6 times)<br />[[Ho Leung Ho Lee Prize]] (2014)
| thesis_year = <!--(or | thesis1_year = and | thesis2_year = )-->
| website = <!--{{URL|www.example.com}}-->
| doctoral_advisor = <!--(or | doctoral_advisors = )-->
| module = {{Infobox Chinesescientist| child=yes
| academic_advisors =
| fields = [[Epidemiology]]
| doctoral_students =
| workplaces = First Affiliated Hospital of [[Zhejiang University]]
| notable_students =
| known_for =
| signature = <!--(filename only)-->
| signature_alt =
| website = <!--{{URL|www.example.com}}-->
| module = {{Infobox Chinese|child=yes
|s = {{linktext|李|兰|娟}}
|t = {{linktext|李|蘭|娟}}
|p = Lǐ Lánjuān
|w =
}}
| module2 = {{Infobox Chinese|child=yes
| s = {{linktext|李|兰|娟}}
| t = {{linktext|李|蘭|娟}}
| p = Lǐ Lánjuān
}}
}}
'''Li Lanjuan''' ({{zh|s=李兰娟<!-- see MOS:ZH -->}}; born 13 September 1947), also romanized as '''Lan-Juan Li''', is a [[Chinese people|Chinese]] [[epidemiologist]] and [[hepatologist]]. She is a professor at [[Zhejiang University School of Medicine]], an academician of the [[Chinese Academy of Engineering]], and serves as the director of the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. She developed Li-NBAL, an artificial [[liver support system]] that is widely used to sustain the lives of people suffering from [[acute liver failure]], and won multiple national awards for her roles in combatting the [[SARS]], [[H1N1]], and [[H7N9]] epidemics.
 
==Early life and education==
Li was born on 13 September 1947<ref name=":0" /> into a poor peasant family in [[Shaoxing]], [[Zhejiang]]. She excelled in her studies and tested into [[Hangzhou High School]], a provincial key school.<ref name=":1">{{Cite news|url=https://news.sina.com.cn/c/2020-01-31/doc-iimxyqvy9372908.shtml|script-title=zh:这位中国感染病学科唯一女院士 率先提出武汉封城|date=31 January 2020|work=Sina News|url-status=live|archive-url=|archive-date=|access-date=2 February 2020}}</ref>
 
After graduation, she became a middle school substitute teacher in her township. She also studied [[acupuncture]] at Zhejiang Chinese Medicine Hospital and performed acupuncture for local elders. Her village later recommended her to become a [[barefoot doctor]], and she accepted the offer despite it paying much less than her teaching job.<ref name=":1" /> In 1970, when Chinese universities began admitting [[Worker-Peasant-Soldier student]]s, Li was recommended by her township to study at [[Zhejiang Medical University]] (now [[Zhejiang University School of Medicine]]).<ref name=":1" />
 
==Career==
Upon graduation {{citation needed|date=June 2021}}{{Clarify|date=June 2021}}{{Definition needed|date=June 2021}}{{dubious|date=June 2021}}{{disputed|date=June 2021}} in 1973,<ref name=":0" /> Li was assigned to work at the Department of Infectious Diseases at the {{ill|First Affiliated Hospital of Zhejiang University|zh|浙江大学第一附属医院}}, commencing her career in epidemiology.<ref name=":1" /> [[Acute liver failure]] caused by [[hepatitis B]] was very common in China. In 1986, Li and her team developed an artificial [[liver support system]] (ALSS), also called non-biological artificial liver (NBAL), to detoxify affected people and sustain their lives until the liver regenerates itself or a donor liver becomes available for [[liver transplantation|transplant]].<ref name="Ning2019">{{cite book|url=https://books.google.com/books?id=0LWZDwAAQBAJ&pg=PA332|title=Acute Exacerbation of Chronic Hepatitis B: Volume 2. Diagnosis and Management|last=Ning|first=Qin|publisher=Springer|year=2019|isbn=978-94-024-1603-9|page=332}}</ref> The system, now known as Li-NBAL,<ref name="Ning2019" /> has significantly improved survival rates for people with severe chronic hepatitis.<ref name="Chang2017">{{cite book|url=https://books.google.com/books?id=COutDgAAQBAJ&pg=PA193|title=Hemoperfusion, Plasmaperfusion And Other Clinical Uses Of General, Biospecific, Immuno And Leucocyte Adsorbents|last1=Chang|first1=Thomas Ming Swi|last2=Endo|first2=Yoshihiro|last3=Nikolaev|first3=Volodymyr|publisher=World Scientific|year=2017|isbn=978-981-4749-09-1|page=193}}</ref> Instead of patenting the invention, she disseminated the technology to more than 300 hospitals all over China free of charge.<ref name=":1" />
Upon graduation in 1973,<ref name=":0" /> Li was assigned to work at the Department of Infectious Diseases at the {{ill|First Affiliated Hospital of Zhejiang University|zh|浙江大学第一附属医院}}, commencing her career in epidemiology.<ref name=":1" />
 
[[Acute liver failure]] caused by [[hepatitis B]] was very common in China. In 1986, Li and her team developed an artificial [[liver support system]] (ALSS), also called non-biological artificial liver (NBAL), to detoxify affected people and sustain their lives until the liver regenerates itself or a donor liver becomes available for [[liver transplantation|transplant]].<ref name="Ning2019">{{cite book|url=https://books.google.com/books?id=0LWZDwAAQBAJ&pg=PA332|title=Acute Exacerbation of Chronic Hepatitis B: Volume 2. Diagnosis and Management|last=Ning|first=Qin|publisher=Springer|year=2019|isbn=978-94-024-1603-9|page=332}}</ref> The system, now known as Li-NBAL,<ref name="Ning2019" /> has significantly improved survival rates for people with severe chronic hepatitis.<ref name="Chang2017">{{cite book|url=https://books.google.com/books?id=COutDgAAQBAJ&pg=PA193|title=Hemoperfusion, Plasmaperfusion And Other Clinical Uses Of General, Biospecific, Immuno And Leucocyte Adsorbents|last1=Chang|first1=Thomas Ming Swi|last2=Endo|first2=Yoshihiro|last3=Nikolaev|first3=Volodymyr|publisher=World Scientific|year=2017|isbn=978-981-4749-09-1|page=193}}</ref> Instead of patenting the invention, she disseminated the technology to more than 300 hospitals all over China free of charge.<ref name=":1" />
She was appointed Vice President of the First Affiliated Hospital of Zhejiang University in October 1993, a position she held for three years. In November 1996 she became deputy director of the State Key Laboratory of Infectious Diseases of [[Ministry of Health of the People's Republic of China|Ministry of Health]], and was promoted to director six years later. She also served as Director of the Department of Health of the Zhejiang Provincial Government from 1998 to 2008.<ref name=":0">{{Cite web|url=http://ysg.ckcest.cn/ysgDetails/baseInfo/717/grxx_jbxx.html|script-title=zh:李兰娟|website=Chinese Academy of Engineering|url-status=live|archive-url=|archive-date=|access-date=22 January 2020}}</ref>
 
===SARS===
 
During the [[2003 SARS outbreak]], Li led the disease prevention effort in Zhejiang and effectively controlled the disease's spread in the province.<ref name=":2">{{cite news|author1=Fang Kun ({{lang|zh|方堃}})|url=http://www.chinanews.com/sh/2018/01-12/8422134.shtml |script-title=zh:李兰娟院士团队荣获2017年度国家科技进步特等奖 |work=China News |date=12 January 2018 |accessdateaccess-date=22 January 2020 |language=zh}}</ref> During the 2013 [[avian flu]] outbreak in the [[Yangtze Delta]], Li's team quickly isolated the [[H7N9]] strain as the pathogen and proved that the strain originated from live poultry markets. Her research prompted the government to quickly close all live poultry markets, preventing the spread of the disease to the rest of China.<ref name=":2" /> For her contributions, she was awardedgiven a Specialspecial Prizeprize of the [[State Science and Technology Progress Award]] in 2017.<ref name=":2" />
She was appointed Vice President of the First Affiliated Hospital of Zhejiang University in October 1993, a position she held for three years. In November 1996 she became deputy director of the State Key Laboratory of Infectious Diseases of [[Ministry of Health of the People's Republic of China|Ministry of Health]], and was promoted to director six years later. She also served as Director of the Department of Health of the Zhejiang Provincial Government from 1998 to 2008.<ref name=":0">{{Cite web|url=http://ysg.ckcest.cn/ysgDetails/baseInfo/717/grxx_jbxx.html|script-title=zh:李兰娟|website=Chinese Academy of Engineering|url-status=live|archive-url=|archive-date=|access-date=22 January 2020}}</ref>
 
{{===COVID-19}}===
During the [[2003 SARS outbreak]], Li led the disease prevention effort in Zhejiang and effectively controlled the disease's spread in the province.<ref name=":2">{{cite news|author1=Fang Kun ({{lang|zh|方堃}})|url=http://www.chinanews.com/sh/2018/01-12/8422134.shtml |script-title=zh:李兰娟院士团队荣获2017年度国家科技进步特等奖 |work=China News |date=12 January 2018 |accessdate=22 January 2020 |language=zh}}</ref> During the 2013 [[avian flu]] outbreak in the [[Yangtze Delta]], Li's team quickly isolated the [[H7N9]] strain as the pathogen and proved that the strain originated from live poultry markets. Her research prompted the government to quickly close all live poultry markets, preventing the spread of the disease to the rest of China.<ref name=":2" /> For her contributions, she was awarded a Special Prize of the [[State Science and Technology Progress Award]] in 2017.<ref name=":2" />
 
During the [[2019–20 coronavirusCOVID-19 outbreakpandemic]], Li was one of the firstresearchers towho proposeproposed theto [[2020 Hubei lockdowns|lockdown]] of the center [[Wuhan]]; her(known as Category A prevention and control measures). The lockdown proposal was adopted by the Chinese government, and the [[Wuhan lockdown]] was implemented at 2pm on 23 January 2020 (before the 2020 [[Chinese New Year's Eve]]).<ref>{{cite news | url=https://www.scmp.com/news/china/society/article/3078189/build-coronavirus-lockdown-inside-chinas-decision-close-wuhan | title=Build-up to coronavirus lockdown: inside China's decision to close Wuhan | first=Echo | last=Xie | date=2 April 2020 | access-date=22 April 2020 | newspaper=[[South China Morning Post]] }}</ref><ref name=":1" /> On 1 February, she left for Wuhan with a team of medical workers from [[Hangzhou]] to help combat the epidemic.<ref>{{Cite web|url=http://paper.cnwomen.com.cn/content/2020-02/02/066822.html?sh=top|script-title=zh:李兰娟乔杰两位女院士带队出发驰援武汉|date=2 February 2020|website=China Women's News|url-status=live|archive-url=|archive-date=|access-date=3 February 2020}}</ref><ref>{{Cite web|url=https://www.thepaper.cn/newsDetail_forward_5721590|script-title=zh:李兰娟院士带队驰援武汉:为抢救危重症病人,没考虑何时回来|date=1 February 2020|website=The Paper|urlaccess-statusdate=live|archive3 February 2020}}</ref> On 20 April 2020, Stephen Chen from the ''[[South China Morning Post]]'' reported on research by Li and her team at Zhejiang University, identifying over 30 strains of the [[SARS-CoV-2]] virus, and that some of more aggressive strains generated 270 times as much [[viral load]] as the mildest versions. They discovered that the aggressive strains were linked to outbreaks in Europe and in the state of New York, whereas the less aggressive strains were found in the states of Washington and California.<ref>{{cite news | url=|archivehttps://www.scmp.com/news/china/science/article/3080771/coronavirus-mutations-affect-deadliness-strains-chinese-study | title=Coronavirus's ability to mutate has been vastly underestimated, and mutations affect deadliness of strains, Chinese study finds | first=Stephen | last=Chen | newspaper=[[South China Morning Post]] | date=20 April 2020 | access-date=322 FebruaryApril 2020}}</ref>
 
==Honours and awards==
* 1998 [[State Science and Technology Progress Award]] (Second Class), for research on artificial liver support system<ref name="awards">{{Cite web|url=http://ysg.ckcest.cn/ysgDetails/achievementStyle/717/cjgx_kjjx.html|script-title=zh:科技奖项|website=Chinese Academy of Engineering|url-status=live|archive-url=|archive-date=|access-date=3 February 2020}}</ref>
* 2005 elected as an academician of the [[Chinese Academy of Engineering]] (CAE)<ref name=":0" />
* 2007 State Science and Technology Progress Award (Second Class), for research on the microecology of infectious diseases<ref name=awards />
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* 2015 State Science and Technology Progress Award (First Class), for innovative treatment of terminal liver disease<ref name=awards />
* 2017 State Science and Technology Progress Award (Special Prize), for major innovation and technological breakthrough in prevention systems of epidemics exemplified by the [[H7N9]] avian flu<ref name=awards />
* 2020 Nature's 10: Ten People Who Helped Shape Science in 2020<ref>{{cite news |title=Nature's 10: ten people who helped shape science in 2020 |url=https://www.nature.com/immersive/d41586-020-03435-6/index.html |access-date=16 December 2020 |work=nature.com |date=15 December 2020}}</ref>
* 2021 Fellow of the [[American Institute for Medical and Biological Engineering]]<ref>{{cite news |title=AIMBE ELECTS 2021 FELLOWS |url=https://aimbe.org/2021-aimbe-fellows/ |access-date=20 February 2021 |work=aimbe.org |date=15 February 2021}}</ref>
* 2022 [[UNESCO-Equatorial Guinea International Prize for Research in the Life Sciences]]<ref>{{Cite web|url=https://www.unesco.org/en/articles/innovation-genetic-technologies-rewarded-unesco-equatorial-guinea-international-prize|title=Innovation in genetic technologies rewarded by UNESCO-Equatorial Guinea International Prize for Research in Life Sciences}}</ref>
 
==Personal life==
Li is married to {{ill|[[Zheng Shusen|zh|郑树森 (医学家)}}]], a liver transplant expert and also an academician of the [[Chinese Academy of Engineering]].<ref>{{cite news|author1=Zhang Le ({{lang|zh|张乐}})|url=http://news.sciencenet.cn/htmlnews/2012/5/264688.shtm |script-title=zh:郑树森李兰娟院士夫妇发起成立树兰基金 |work=sciencenet.cn |date=26 May 2012 |accessdateaccess-date=22 January 2020 |language=zh}}</ref><ref>{{cite news|author1=Zhang Le ({{lang|zh|张乐}})|author2=Wei Hui ({{lang|zh|韦慧}})|url=http://www.xinhuanet.com/politics/2015-05/23/c_1115383737.htm |script-title=zh:李兰娟院士伉俪:无数次的风雨同舟才能相濡以沫 |work=Xinhua |date=23 May 2015 |accessdateaccess-date=22 January 2020 |language=zh}}</ref> The coupleThey have a son named Zheng Jie ({{lang|zh|郑杰}}).<ref>{{cite news|author=Zhang Zeqian ({{lang|zh|张泽茜}})|url=http://news.sina.com.cn/o/2020-02-02/doc-iimxxste8299337.shtml |script-title=zh:儿子眼里的李兰娟院士:她一直都没有抛弃自己医生的身份 |work=sina |date=2 February 2020 |accessdateaccess-date=3 February 2020}}</ref>
 
==See also==
* [[{{annotated link|Zhong Nanshan]]}}
*[[Chen Wei (medical scientist)|Chen Wei]], medical researcher who won multiple national awards
 
==References==
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*[http://en.cae.cn/en/Members%20Activities/20150810/cae12044.html Li Lanjuan] on the [[Chinese Academy of Engineering]] (CAE)
 
{{COVID-19 pandemic}}
{{Members of the Chinese Academy of Engineering (2005)}}
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[[Category:Chinese epidemiologists]]
[[Category:Chinese hepatologists]]
[[Category:21st-century Chinese women physicians]]
[[Category:Members of the Chinese Academy of Engineering]]
[[Category:Physicians from Zhejiang]]
[[Category:Scientists from Shaoxing]]
[[Category:Chinese Communist Party politicians from Zhejiang]]
[[Category:Zhejiang University alumni]]
[[Category:Academic staff of Zhejiang University faculty]]
[[Category:Coronavirus researchers]]
[[Category:Women hepatologists]]
[[Category:20th-century women physicians]]
[[Category:20th-century Chinese women scientists]]
[[Category:21st-century Chinese women scientists]]
[[Category:Women epidemiologists]]
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