Niall O'Brien may refer to:
- Niall O'Brien (actor) (1946–2009), Irish actor
- Niall O'Brien (cricketer) (born 1981), Irish cricketer
- Niall O'Brien (hurler) (born 1994), Irish hurler
- Niall O'Brien (priest) (1939–2004), Irish Columban missionary priest
See also
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