Polysorbate: Difference between revisions
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The diagram shows polysorbate-20, not 60, as per the polysorbate-20 article (where the same picture is labeled polysorbate-20), and as per the repeating unit count being 20. Changed 60 to 20. Tags: Reverted Visual edit Mobile edit Mobile web edit |
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{{Missing information|cross-reaction with PEG hypersensitivity [PMID: 30557713]|date=April 2021}} |
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[[File:Polysorbate 60.png|thumb|right|300px|Polysorbate |
[[File:Polysorbate 60.png|thumb|right|300px|Polysorbate 20, a compound used as a food additive in some pudding mixes to prevent scorching during preparation]] |
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'''Polysorbates''' are a class of [[emulsifier]]s used in some pharmaceuticals and food preparation. They are commonly used in oral and topical pharmaceutical dosage forms. They are also often used in cosmetics to solubilize [[essential oil]]s into water-based products. Polysorbates are oily liquids derived from [[ethoxylation|ethoxylated]] [[sorbitan]] (a derivative of [[sorbitol]]) [[ester]]ified with [[fatty acid]]s. Common brand names for polysorbates include Kolliphor,<ref>{{Cite web |title=Pharmaceutical Polysorbates |url=https://pharma.basf.com/chemistry/polysorbates-and-sorbitan-esters?at_medium=display&at_campaign=enp_baw_glob_en_sol_tra_wikipedia&at_creation=landing-page_wikipedia_chemistry-page_basf-wikipedia-article&at_channel=wikipedia&at_format=chemistry-page&at_variant=basf-wikipedia-article |access-date=2021-04-27 |website=pharmaceutical.basf.com |language=en}}</ref> Scattics, Alkest, Canarcel, and Tween.<ref name=Ullmann>Hubert Schiweck, Albert Bär, Roland Vogel, Eugen Schwarz, Markwart Kunz, Cécile Dusautois, Alexandre Clement, Caterine Lefranc, Bernd Lüssem, Matthias Moser, Siegfried Peters "Sugar Alcohols" Ullmann's Encyclopedia of Industrial Chemistry, 2012, Wiley-VCH, Weinheim. {{DOI|10.1002/14356007.a25_413.pub3}}</ref> |
'''Polysorbates''' are a class of [[emulsifier]]s used in some pharmaceuticals and food preparation. They are commonly used in oral and topical pharmaceutical dosage forms. They are also often used in cosmetics to solubilize [[essential oil]]s into water-based products. Polysorbates are oily liquids derived from [[ethoxylation|ethoxylated]] [[sorbitan]] (a derivative of [[sorbitol]]) [[ester]]ified with [[fatty acid]]s. Common brand names for polysorbates include Kolliphor,<ref>{{Cite web |title=Pharmaceutical Polysorbates |url=https://pharma.basf.com/chemistry/polysorbates-and-sorbitan-esters?at_medium=display&at_campaign=enp_baw_glob_en_sol_tra_wikipedia&at_creation=landing-page_wikipedia_chemistry-page_basf-wikipedia-article&at_channel=wikipedia&at_format=chemistry-page&at_variant=basf-wikipedia-article |access-date=2021-04-27 |website=pharmaceutical.basf.com |language=en}}</ref> Scattics, Alkest, Canarcel, and Tween.<ref name=Ullmann>Hubert Schiweck, Albert Bär, Roland Vogel, Eugen Schwarz, Markwart Kunz, Cécile Dusautois, Alexandre Clement, Caterine Lefranc, Bernd Lüssem, Matthias Moser, Siegfried Peters "Sugar Alcohols" Ullmann's Encyclopedia of Industrial Chemistry, 2012, Wiley-VCH, Weinheim. {{DOI|10.1002/14356007.a25_413.pub3}}</ref> |
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Revision as of 23:06, 3 July 2022
 | This article is missing information about cross-reaction with PEG hypersensitivity [PMID: 30557713]. (April 2021) |
Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are commonly used in oral and topical pharmaceutical dosage forms. They are also often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from ethoxylated sorbitan (a derivative of sorbitol) esterified with fatty acids. Common brand names for polysorbates include Kolliphor,[1] Scattics, Alkest, Canarcel, and Tween.[2]
Examples
- Polysorbate 20 (polyoxyethylene (20) sorbitan monolaurate)
- Polysorbate 40 (polyoxyethylene (20) sorbitan monopalmitate)
- Polysorbate 60 (polyoxyethylene (20) sorbitan monostearate)
- Polysorbate 80 (polyoxyethylene (20) sorbitan monooleate)
The number following the 'polysorbate' part is related to the type of major fatty acid associated with the molecule. Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80. The number 20 following the 'polyoxyethylene' part refers to the total number of oxyethylene (–CH2CH2O–) groups found in the molecule.
See also
References
- ^ "Pharmaceutical Polysorbates". pharmaceutical.basf.com. Retrieved 2021-04-27.
- ^ Hubert Schiweck, Albert Bär, Roland Vogel, Eugen Schwarz, Markwart Kunz, Cécile Dusautois, Alexandre Clement, Caterine Lefranc, Bernd Lüssem, Matthias Moser, Siegfried Peters "Sugar Alcohols" Ullmann's Encyclopedia of Industrial Chemistry, 2012, Wiley-VCH, Weinheim. doi:10.1002/14356007.a25_413.pub3
External links
- NIH PEG-60 (Polysorbate 60) Household Products Database
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