Jump to content

TRA (gene): Difference between revisions

From Wikipedia, the free encyclopedia
Content deleted Content added
Citation bot (talk | contribs)
Add: s2cid. | Use this bot. Report bugs. | Suggested by Whoop whoop pull up | Category:Genes on human chromosome | #UCB_Category 371/484
 
(12 intermediate revisions by 7 users not shown)
Line 1: Line 1:
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Underlinked|date=September 2016}}
{{For|the female-specific protein transformer gene in Drosophila melanogaster|Tra (gene)}}
{{Infobox_gene}}
{{Infobox_gene}}
'''T-cell receptor alpha locus''' is a [[protein]] that in humans is encoded by the '''TRA''' [[gene]], also known as TCRA or TRA@.<ref name="pmid3875152">{{cite journal |vauthors=Erikson J, Williams DL, Finan J, Nowell PC, Croce CM | title = Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias | journal = Science | volume = 229 | issue = 4715 | pages = 784–6 |date=Sep 1985 | pmid = 3875152 | pmc = | doi =10.1126/science.3875152 }}</ref><ref name="pmid3875483">{{cite journal |vauthors=Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN | title = The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia | journal = EMBO J | volume = 4 | issue = 6 | pages = 1461–5 |date=Oct 1985 | pmid = 3875483 | pmc = 554368 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRA@ T cell receptor alpha locus| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6955| accessdate = }}</ref> It contributes the alpha chain to the larger TCR protein ([[T-cell receptor]]).
'''T-cell receptor alpha locus''' is a [[protein]] that in humans is encoded by the '''TRA''' [[gene]], also known as TCRA or TRA@.<ref name="pmid3875152">{{cite journal |vauthors=Erikson J, Williams DL, Finan J, Nowell PC, Croce CM | title = Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias | journal = Science | volume = 229 | issue = 4715 | pages = 784–6 |date=Sep 1985 | pmid = 3875152 | doi =10.1126/science.3875152 | bibcode = 1985Sci...229..784E }}</ref><ref name="pmid3875483">{{cite journal |vauthors=Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN | title = The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia | journal = EMBO J | volume = 4 | issue = 6 | pages = 1461–5 |date=Oct 1985 | pmid = 3875483 | pmc = 554368 | doi = 10.1002/j.1460-2075.1985.tb03803.x}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRA@ T cell receptor alpha locus| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6955}}</ref> It contributes the alpha chain to the larger TCR protein ([[T-cell receptor]]).



<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
==References==
Line 14: Line 11:
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | author=Kenwrick S |title=Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene |journal=Hum. Mol. Genet. |volume=1 |issue= 3 |pages= 179–86 |year= 1993 |pmid= 1303175 |doi=10.1093/hmg/1.3.179 |name-list-format=vanc| author2=Levinson B | author3=Taylor S | display-authors=3 | last4=Shapiro | first4=Amy | last5=Gitschier | first5=Jane }}
*{{cite journal | author=Kenwrick S |title=Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene |journal=Hum. Mol. Genet. |volume=1 |issue= 3 |pages= 179–86 |year= 1993 |pmid= 1303175 |doi=10.1093/hmg/1.3.179 |name-list-style=vanc| author2=Levinson B | author3=Taylor S | display-authors=3 | last4=Shapiro | first4=Amy | last5=Gitschier | first5=Jane }}
*{{cite journal | author=Suzuki CK |title=Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP |journal=J. Cell Biol. |volume=114 |issue= 2 |pages= 189–205 |year= 1991 |pmid= 1649196 |doi=10.1083/jcb.114.2.189 | pmc=2289081 |name-list-format=vanc| author2=Bonifacino JS | author3=Lin AY | display-authors=3 | last4=Davis | first4=MM | last5=Klausner | first5=RD }}
*{{cite journal | author=Suzuki CK |title=Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP |journal=J. Cell Biol. |volume=114 |issue= 2 |pages= 189–205 |year= 1991 |pmid= 1649196 |doi=10.1083/jcb.114.2.189 | pmc=2289081 |name-list-style=vanc| author2=Bonifacino JS | author3=Lin AY | display-authors=3 | last4=Davis | first4=MM | last5=Klausner | first5=RD }}
*{{cite journal |vauthors=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=10.1101/gad.5.5.880 }}
*{{cite journal |vauthors=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=10.1101/gad.5.5.880 |doi-access=free }}
*{{cite journal |vauthors=Koning F, Maloy WL, Coligan JE |title=The implications of subunit interactions for the structure of the T cell receptor-CD3 complex |journal=Eur. J. Immunol. |volume=20 |issue= 2 |pages= 299–305 |year= 1990 |pmid= 2138083 |doi=10.1002/eji.1830200211 }}
*{{cite journal |vauthors=Koning F, Maloy WL, Coligan JE |title=The implications of subunit interactions for the structure of the T cell receptor-CD3 complex |journal=Eur. J. Immunol. |volume=20 |issue= 2 |pages= 299–305 |year= 1990 |pmid= 2138083 |doi=10.1002/eji.1830200211 |s2cid=2180901 }}
*{{cite journal | author=Dyer MJ |title=T-cell receptor delta/alpha rearrangements in lymphoid neoplasms |journal=Blood |volume=74 |issue= 3 |pages= 1073–83 |year= 1989 |pmid= 2546634 |doi= }}
*{{cite journal | author=Dyer MJ |title=T-cell receptor delta/alpha rearrangements in lymphoid neoplasms |journal=Blood |volume=74 |issue= 3 |pages= 1073–83 |year= 1989 |pmid= 2546634 |doi= 10.1182/blood.V74.3.1073.1073|doi-access=free }}
*{{cite journal |vauthors=Chilson OP, Kelly-Chilson AE |title=Mitogenic lectins bind to the antigen receptor on human lymphocytes |journal=Eur. J. Immunol. |volume=19 |issue= 2 |pages= 389–96 |year= 1989 |pmid= 2703017 |doi=10.1002/eji.1830190225 }}
*{{cite journal |vauthors=Chilson OP, Kelly-Chilson AE |title=Mitogenic lectins bind to the antigen receptor on human lymphocytes |journal=Eur. J. Immunol. |volume=19 |issue= 2 |pages= 389–96 |year= 1989 |pmid= 2703017 |doi=10.1002/eji.1830190225 |s2cid=22340836 }}
*{{cite journal | author=Yanagi Y |title=Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 10 |pages= 3430–4 |year= 1985 |pmid= 3873654 |doi=10.1073/pnas.82.10.3430 | pmc=397789 |name-list-format=vanc| author2=Chan A | author3=Chin B | display-authors=3 | last4=Minden | first4=M | last5=Mak | first5=TW }}
*{{cite journal | author=Yanagi Y |title=Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 10 |pages= 3430–4 |year= 1985 |pmid= 3873654 |doi=10.1073/pnas.82.10.3430 | pmc=397789 |name-list-style=vanc| author2=Chan A | author3=Chin B | display-authors=3 | last4=Minden | first4=M | last5=Mak | first5=TW |bibcode=1985PNAS...82.3430Y |doi-access=free }}
*{{cite journal | author=Sim GK |title=Primary structure of human T-cell receptor alpha-chain |journal=Nature |volume=312 |issue= 5996 |pages= 771–5 |year= 1985 |pmid= 6440030 |doi=10.1038/312771a0 |name-list-format=vanc| author2=Yagüe J | author3=Nelson J | display-authors=3 | last4=Marrack | first4=Philippa | last5=Palmer | first5=Edward | last6=Augustin | first6=Andrei | last7=Kappler | first7=John }}
*{{cite journal | author=Sim GK |title=Primary structure of human T-cell receptor alpha-chain |journal=Nature |volume=312 |issue= 5996 |pages= 771–5 |year= 1985 |pmid= 6440030 |doi=10.1038/312771a0 |name-list-style=vanc| author2=Yagüe J | author3=Nelson J | display-authors=3 | last4=Marrack | first4=Philippa | last5=Palmer | first5=Edward | last6=Augustin | first6=Andrei | last7=Kappler | first7=John |s2cid=4350315 }}
*{{cite journal |vauthors=Kearse KP, Roberts JL, Singer A |title=TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes |journal=Immunity |volume=2 |issue= 4 |pages= 391–9 |year= 1995 |pmid= 7719941 |doi= 10.1016/1074-7613(95)90147-7 }}
*{{cite journal |vauthors=Kearse KP, Roberts JL, Singer A |title=TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes |journal=Immunity |volume=2 |issue= 4 |pages= 391–9 |year= 1995 |pmid= 7719941 |doi= 10.1016/1074-7613(95)90147-7 |doi-access= free }}
*{{cite journal |vauthors=Manolios N, Kemp O, Li ZG |title=The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains |journal=Eur. J. Immunol. |volume=24 |issue= 1 |pages= 84–92 |year= 1994 |pmid= 8020575 |doi=10.1002/eji.1830240114 }}
*{{cite journal |vauthors=Manolios N, Kemp O, Li ZG |title=The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains |journal=Eur. J. Immunol. |volume=24 |issue= 1 |pages= 84–92 |year= 1994 |pmid= 8020575 |doi=10.1002/eji.1830240114 |s2cid=85378646 }}
*{{cite journal |vauthors=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi=10.1101/gad.11.5.629 }}
*{{cite journal |vauthors=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi=10.1101/gad.11.5.629 |doi-access=free }}
*{{cite journal |vauthors=San José E, Sahuquillo AG, Bragado R, Alarcón B |title=Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model |journal=Eur. J. Immunol. |volume=28 |issue= 1 |pages= 12–21 |year= 1998 |pmid= 9485181 |doi=10.1002/(SICI)1521-4141(199801)28:01<12::AID-IMMU12>3.0.CO;2-9 }}
*{{cite journal |vauthors=San José E, Sahuquillo AG, Bragado R, Alarcón B |title=Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model |journal=Eur. J. Immunol. |volume=28 |issue= 1 |pages= 12–21 |year= 1998 |pmid= 9485181 |doi=10.1002/(SICI)1521-4141(199801)28:01<12::AID-IMMU12>3.0.CO;2-9 |s2cid=85318973 }}
*{{cite journal | author=Ding YH |title=Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids |journal=Immunity |volume=8 |issue= 4 |pages= 403–11 |year= 1998 |pmid= 9586631 |doi=10.1016/S1074-7613(00)80546-4 |name-list-format=vanc| author2=Smith KJ | author3=Garboczi DN | display-authors=3 | last4=Utz | first4=Ursula | last5=Biddison | first5=William E. | last6=Wiley | first6=Don C. }}
*{{cite journal | author=Ding YH |title=Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids |journal=Immunity |volume=8 |issue= 4 |pages= 403–11 |year= 1998 |pmid= 9586631 |doi=10.1016/S1074-7613(00)80546-4 |name-list-style=vanc| author2=Smith KJ | author3=Garboczi DN | display-authors=3 | last4=Utz | first4=Ursula | last5=Biddison | first5=William E. | last6=Wiley | first6=Don C. | doi-access=free }}
*{{cite journal | author=Kirchgessner H |title=The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain |journal=J. Exp. Med. |volume=193 |issue= 11 |pages= 1269–84 |year= 2001 |pmid= 11390434 |doi=10.1084/jem.193.11.1269 | pmc=2193385 |name-list-format=vanc| author2=Dietrich J | author3=Scherer J | display-authors=3 | last4=Isomaki | first4=P. | last5=Korinek | first5=V. | last6=Hilgert | first6=I. | last7=Bruyns | first7=E. | last8=Leo | first8=A. | last9=Cope | first9=A. P. }}
*{{cite journal | author=Kirchgessner H |title=The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain |journal=J. Exp. Med. |volume=193 |issue= 11 |pages= 1269–84 |year= 2001 |pmid= 11390434 |doi=10.1084/jem.193.11.1269 | pmc=2193385 |name-list-style=vanc| author2=Dietrich J | author3=Scherer J | display-authors=3 | last4=Isomaki | first4=P. | last5=Korinek | first5=V. | last6=Hilgert | first6=I. | last7=Bruyns | first7=E. | last8=Leo | first8=A. | last9=Cope | first9=A. P. }}
*{{cite journal | author=Shelton JG |title=Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits |journal=Mol. Immunol. |volume=38 |issue= 4 |pages= 259–65 |year= 2001 |pmid= 11566319 |doi=10.1016/S0161-5890(01)00062-1 |name-list-format=vanc| author2=Gülland S | author3=Nicolson K | display-authors=3 | last4=Kearse | first4=Kelly P | last5=Thomas Bäckström | first5=B }}
*{{cite journal | author=Shelton JG |title=Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits |journal=Mol. Immunol. |volume=38 |issue= 4 |pages= 259–65 |year= 2001 |pmid= 11566319 |doi=10.1016/S0161-5890(01)00062-1 |name-list-style=vanc| author2=Gülland S | author3=Nicolson K | display-authors=3 | last4=Kearse | first4=Kelly P | last5=Thomas Bäckström | first5=B }}
*{{cite journal | author=Pietra G |title=The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition |journal=Eur. J. Immunol. |volume=31 |issue= 12 |pages= 3687–93 |year= 2002 |pmid= 11745389 |doi=10.1002/1521-4141(200112)31:12<3687::AID-IMMU3687>3.0.CO;2-C |name-list-format=vanc| author2=Romagnani C | author3=Falco M | display-authors=3 | last4=Vitale | first4=Massimo | last5=Castriconi | first5=Roberta | last6=Pende | first6=Daniela | last7=Millo | first7=Enrico | last8=Anfossi | first8=Simone | last9=Biassoni | first9=Roberto }}
*{{cite journal | author=Pietra G |title=The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition |journal=Eur. J. Immunol. |volume=31 |issue= 12 |pages= 3687–93 |year= 2002 |pmid= 11745389 |doi=10.1002/1521-4141(200112)31:12<3687::AID-IMMU3687>3.0.CO;2-C |name-list-style=vanc| author2=Romagnani C | author3=Falco M | display-authors=3 | last4=Vitale | first4=Massimo | last5=Castriconi | first5=Roberta | last6=Pende | first6=Daniela | last7=Millo | first7=Enrico | last8=Anfossi | first8=Simone | last9=Biassoni | first9=Roberto | doi-access=free }}
*{{cite journal |vauthors=Hennecke J, Wiley DC |title=Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity |journal=J. Exp. Med. |volume=195 |issue= 5 |pages= 571–81 |year= 2002 |pmid= 11877480 |doi=10.1084/jem.20011194 | pmc=2193773 }}
*{{cite journal |vauthors=Hennecke J, Wiley DC |title=Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity |journal=J. Exp. Med. |volume=195 |issue= 5 |pages= 571–81 |year= 2002 |pmid= 11877480 |doi=10.1084/jem.20011194 | pmc=2193773 }}
*{{cite journal | author=García P |title=Human T cell receptor-mediated recognition of HLA-E |journal=Eur. J. Immunol. |volume=32 |issue= 4 |pages= 936–44 |year= 2002 |pmid= 11920559 |doi=10.1002/1521-4141(200204)32:4<936::AID-IMMU936>3.0.CO;2-M |name-list-format=vanc| author2=Llano M | author3=de Heredia AB | display-authors=3 | last4=Willberg | first4=Christian B. | last5=Caparrós | first5=Esther | last6=Aparicio | first6=Pedro | last7=Braud | first7=Véronique M. | last8=López-Botet | first8=Miguel }}
*{{cite journal | author=García P |title=Human T cell receptor-mediated recognition of HLA-E |journal=Eur. J. Immunol. |volume=32 |issue= 4 |pages= 936–44 |year= 2002 |pmid= 11920559 |doi=10.1002/1521-4141(200204)32:4<936::AID-IMMU936>3.0.CO;2-M |name-list-style=vanc| author2=Llano M | author3=de Heredia AB | display-authors=3 | last4=Willberg | first4=Christian B. | last5=Caparrós | first5=Esther | last6=Aparicio | first6=Pedro | last7=Braud | first7=Véronique M. | last8=López-Botet | first8=Miguel | doi-access=free }}
{{refend}}
{{refend}}



Latest revision as of 00:14, 15 October 2022

TRA
Identifiers
AliasesTRA, IMD7, TCRA, TRA@, TRAC, T-cell receptor alpha locus, TCRD, T cell receptor alpha locus
External IDsGeneCards: TRA; OMA:TRA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@.[2][3][4] It contributes the alpha chain to the larger TCR protein (T-cell receptor).


References

[edit]
  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ Erikson J, Williams DL, Finan J, Nowell PC, Croce CM (Sep 1985). "Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias". Science. 229 (4715): 784–6. Bibcode:1985Sci...229..784E. doi:10.1126/science.3875152. PMID 3875152.
  3. ^ Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN (Oct 1985). "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia". EMBO J. 4 (6): 1461–5. doi:10.1002/j.1460-2075.1985.tb03803.x. PMC 554368. PMID 3875483.
  4. ^ "Entrez Gene: TRA@ T cell receptor alpha locus".

Further reading

[edit]


pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy