Concentración ni ri pi Abbott Miller y Tainter

0 10 1 0.1
1 10 1 0.1 0.000 0.050
2 10 3 0.3 0.222 0.222
4 10 7 0.7 0.667 0.667
8 10 6 0.6 0.556 0.556
16 10 8 0.8 0.778 0.778
32 10 9 0.9 0.889 0.889
64 10 9 0.9 0.889 0.889
128 10 10 1 1.000 0.950

Concentración ni ri pi Abbott Miller y Tainter

0 10 2 0.2
1 10 2 0.2 0.000
2 10 2 0.2 0.000 0.050
4 10 4 0.4 0.250 0.250
8 10 5 0.5 0.375 0.375
16 10 7 0.7 0.625 0.625
32 10 9 0.9 0.875 0.875
64 10 10 1 1.000 0.950
128 10 10 1 1.000

xi yi
0.000 3.355
0.301 4.235 Chart Title
0.301 3.355 7
f(x) = 1.63363019626455 x + 3.52818487394958
0.602 5.431 R² = 0.883024732679621
6
0.602 4.326
0.903 5.140 5
0.903 4.681
1.204 5.765 4

1.204 5.319 3
1.505 6.221
1.505 6.150 2
1.806 6.221
1
1.806 6.645
2.107 6.645 0
0.000 0.500 1.000 1.500

β m 1.634 CL50 7.961

α b 3.528 CL16 1.972
CL84 32.134
S 15.081
N'= 100 EEM 2.133
t= 1.973 LIC 3.752
LSC 12.169
 zi yi xi

-1.645 3.355 0.000

-0.765 4.235 0.301
0.431 5.431 0.602
0.140 5.140 0.903
0.765 5.765 1.204
1.221 6.221 1.505
1.221 6.221 1.806
1.645 6.645 2.107

zi yi xi

#VALUE! #VALUE! 0.000

-1.645 3.355 0.301
-0.674 4.326 0.602
-0.319 4.681 0.903
0.319 5.319 1.204
1.150 6.150 1.505
1.645 6.645 1.806
#VALUE! #VALUE! 2.107

Chart Title
3.52818487394958

1.000 1.500 2.000 2.500

CL50= 7.961±2.134 mg/mL

IC95= 3.750-12.171 mg/mL
 Concentración ni ri pi pi corregido
0 10 1 0.1
1 10 1 0.1 0.000
2 10 3 0.3 0.222
4 10 7 0.7 0.667
8 10 6 0.6 0.556
16 10 8 0.8 0.778
32 10 9 0.9 0.889
64 10 9 0.9 0.889
128 10 10 1 1.000

Concentración ni ri pi pi corregido
0 10 2 0.2
1 10 2 0.2 0.000
2 10 2 0.2 0.000
4 10 4 0.4 0.250
8 10 5 0.5 0.375
16 10 7 0.7 0.625
32 10 9 0.9 0.875
64 10 10 1 1.000
128 10 10 1 1.000

xi yi
0.301 4.235 Chart Title
0.602 5.431 7
0.602 4.326
6 f(x) = 1.40531561461794 x + 3.8684
0.903 5.140 R² = 0.786235541367039
0.903 4.681 5
1.204 5.765
4
1.204 5.319
1.505 6.221 3
1.505 6.150
1.806 6.221 2

0
0.200 0.400 0.600 0.800 1.000 1.200
m 1.405
b 3.868

CL50 6.386

Segundo paso yi calculada zi φzi Pi acumulada 1-Pi acumulada

3.868 -1.132 0.210 0.129 0.871
4.291 -0.709 0.310 0.239 0.761
4.714 -0.286 0.383 0.388 0.612
5.138 0.138 0.395 0.555 0.445
5.561 0.561 0.341 0.712 0.288
5.984 0.984 0.246 0.837 0.163
6.407 1.407 0.148 0.920 0.080
 6.830 1.830 0.075 0.966 0.034

3.868 -1.132 0.210 0.129 0.871

4.291 -0.709 0.310 0.239 0.761
4.714 -0.286 0.383 0.388 0.612
5.138 0.138 0.395 0.555 0.445
5.561 0.561 0.341 0.712 0.288
5.984 0.984 0.246 0.837 0.163
6.407 1.407 0.148 0.920 0.080
6.830 1.830 0.075 0.966 0.034

Limites de confianza
Sμ^2= 0.0043
Sμ= 0.0652
t= 1.9734 N= 180
μsup= 1.0044
μinf= 0.7469

LSC= 10.101
LIC= 5.584
 pi ajustada zi yi xi

0.050 -1.645 3.355 0.000

0.222 -0.765 4.235 0.301
0.667 0.431 5.431 0.602
0.556 0.140 5.140 0.903
0.778 0.765 5.765 1.204
0.889 1.221 6.221 1.505
0.889 1.221 6.221 1.806
0.950 1.645 6.645 2.107

pi ajustada zi yi xi

0.05 -1.645 3.355 0.000

0.05 -1.645 3.355 0.301
0.250 -0.674 4.326 0.602
0.375 -0.319 4.681 0.903
0.625 0.319 5.319 1.204
0.875 1.150 6.150 1.505
0.950 1.645 6.645 1.806
#VALUE! #VALUE! 2.107

Chart Title

0531561461794 x + 3.8684
6235541367039

0.600 0.800 1.000 1.200 1.400 1.600 1.800 2.000

ωi vi niωi niωixi niωixi^2 niωivi niωivixi

0.394 3.255 3.935 0.000 0.000 12.810 0.000
0.529 4.236 5.290 1.592 0.479 22.410 6.746
0.618 5.443 6.178 3.720 2.239 33.629 20.247
0.632 5.140 6.322 5.709 5.156 32.492 29.343
0.567 5.752 5.671 6.829 8.223 32.622 39.281
0.444 6.193 4.438 6.679 10.053 27.483 41.366
0.299 6.195 2.995 5.409 9.770 18.553 33.510
 0.172 7.280 1.719 3.623 7.634 12.515 26.372

0.394 3.255 3.935 0.000 0.000 12.810 0.000

0.529 3.520 5.290 1.592 0.479 18.622 5.606
0.618 4.355 6.178 3.720 2.239 26.907 16.200
0.632 4.683 6.322 5.709 5.156 29.603 26.735
0.567 5.304 5.671 6.829 8.223 30.080 36.220
0.444 6.137 4.438 6.679 10.053 27.232 40.989
0.299 6.945 2.995 5.409 9.770 20.797 37.564
0.172 7.280 1.719 3.623 7.634 12.515 26.372

Ʃ= 73.096 67.122 87.108 371.081 386.549

b= α1= 3.426 CL50(1)= 7.510

m= β1= 1.798 μ= 0.876
Promedio x= 0.918

CL50(1)= 7.510±0.0652 mg/ml

IC95(1)= 5.584-10.101 mg/ml
 1/raíz 2 *pi
0.39894228

0.52691713 0.21020952
0.77783528
0.95992704
0.99052319
0.85439599
0.61623432
0.37164191
0.18741123

niωi(xi-xpromedio)^2
3.318
2.015
0.618
0.001
0.463
1.528
2.361
 2.430

3.318
2.015
0.618
0.001
0.463
1.528
2.361
2.430

25.472
Concentración ni ri pi pi corregido
0 10 1 0.1
1 10 1 0.1 0.000
2 10 3 0.3 0.222
4 10 7 0.7 0.667
8 10 6 0.6 0.556
16 10 8 0.8 0.778
32 10 9 0.9 0.889
64 10 9 0.9 0.889
128 10 10 1 1.000

Concentración ni ri pi pi corregido
0 10 2 0.2
1 10 2 0.2 0.000
2 10 2 0.2 0.000
4 10 4 0.4 0.250
8 10 5 0.5 0.375
16 10 7 0.7 0.625
32 10 9 0.9 0.875
64 10 10 1 1.000
128 10 10 1 1.000

x(Log C) y(pi calculada corregida)

Chart Title
0.000 0.003
1.2
0.000 0.003
0.301 0.193
1
0.301 0.083
f(x) = 0.534290460370195 x + 0.0013928571428572
0.602 0.344 0.8
R² = 0.993806759000424
0.602 0.344
0.903 0.495 0.6
0.903 0.495
1.204 0.646 0.4
1.204 0.646
1.505 0.797 0.2
1.505 0.797
1.806 0.948 0
0.000 0.200 0.400 0.600 0.800 1.000 1.200 1.400
1.806 0.98

m= 0.534
b= 0.0014

CL50= 8.575
CL16= 1.981
CL84= 37.117 N'= 90
S= 4.329
E= 0.292 CL50= 8.575±0.292
FCL50= 1.534 IC95= (5.590-13.153)
LSC= 13.153
LIC= 5.590
 Log C pi calculada pi calculada corregida

0.000 0.042 0.003

0.301 0.193 0.193
0.602 0.344 0.344
0.903 0.495 0.495
1.204 0.646 0.646
1.505 0.797 0.797
1.806 0.948 0.948
2.107 1.099

Log C pi calculada pi calculada corregida

0.000 0.042 0.003

0.301 0.193 0.083
0.602 0.344 0.344
0.903 0.495 0.495
1.204 0.646 0.646
1.505 0.797 0.797
1.806 0.948 0.98
2.107 1.099

Chart Title

x + 0.0013928571428572

0.800 1.000 1.200 1.400 1.600 1.800 2.000

mg/ml
mg/ml
x (Log C) y (pi corregida)
0.000 0.000
0.000 0.000 Chart Title
0.301 0.222 1.200
0.301 0.000
0.602 0.667 f(x) = 0.501265622528081 x + 0.0422916666666667
1.000 R² = 0.892177831114698
0.602 0.250
0.903 0.556 0.800
0.903 0.375
1.204 0.778 0.600

1.204 0.625
0.400
1.505 0.889
1.505 0.875
0.200
1.806 0.889
1.806 1.000 0.000
2.107 1.000 0.000 0.500 1.000 1.500 2.000 2.500

2.107 1.000

m= 0.501
b= 0.042
2.000 2.500
Concentración ni ri pi pi corregido pi corregido SK
0 10 1 0.1
1 10 1 0.1 0.000 0.000
2 10 3 0.3 0.222 0.222
4 10 7 0.7 0.667 0.611
8 10 6 0.6 0.556 0.611
16 10 8 0.8 0.778 0.778
32 10 9 0.9 0.889 0.889
64 10 9 0.9 0.889 0.889
128 10 10 1 1.000 1.000

Concentración ni ri pi pi corregido pi corregido SK

0 10 2 0.2
1 10 2 0.2 0.000
2 10 2 0.2 0.000 0.000
4 10 4 0.4 0.250 0.250
8 10 5 0.5 0.375 0.375
16 10 7 0.7 0.625 0.625
32 10 9 0.9 0.875 0.875
64 10 10 1 1.000 1.000
128 10 10 1 1.000
(pi+1)-pi xi+(xi+1) Log C Producto (xi+(xi+1))^2 Producto 2

0.222 0.301 0.000 0.067 0.091 0.020

0.389 0.903 0.301 0.351 0.816 0.317
0.000 1.505 0.602 0.000 2.265 0.000
0.167 2.107 0.903 0.351 4.440 0.740
0.111 2.709 1.204 0.301 7.340 0.816
0.000 3.311 1.505 0.000 10.965 0.000
0.111 3.913 1.806 0.435 15.315 1.702
2.107

(pi+1)-pi xi+(xi+1) Log C Producto (xi+(xi+1))^2 Producto 2

0.000
0.250 0.903 0.301 0.226 0.816 0.204
0.125 1.505 0.602 0.188 2.265 0.283
0.250 2.107 0.903 0.527 4.440 1.110
0.250 2.709 1.204 0.677 7.340 1.835
0.125 3.311 1.505 0.414 10.965 1.371
1.806
2.107

Ʃ= 3.537 8.398

LogCL50= 0.884
CL50= 7.661
SE= 0.458