Thank you for response. But what about xvfb

    with SB(
            uc=True,
            incognito=True,
            locale="en",
            xvfb=True,
            xvfb_metrics="1920,1080",
    ) as sb:
        sb.set_window_size(1920, 1080)
        sb.activate_cdp_mode(URL)
        sb.cdp.gui_click_x_y(1400, 800)

and i get error

Exception: PyAutoGUI cannot click on point (1400, 800) outside screen. (Width: 1366, Height: 768)

Why i set up 1920x1080 but virtual screen is 1366x768?

PyAutoGUI==0.9.54
seleniumbase==4.36.1

Might be something related to your environment. I'm not seeing that when running in GitHub Actions. Also, be sure you're using the latest version of SeleniumBase (Currently 4.37.1)

upgrade SeleniumBase to 4.37.2. Tried the same code:

with SB(
    uc=True,
    incognito=True,
    locale="en",
    xvfb=True,
    xvfb_metrics="1920,1080",
) as sb:
    sb.set_window_size(1920, 1080)
    sb.activate_cdp_mode(URL)
    sb.cdp.gui_click_x_y(1400, 800)

got the same error:

Exception: PyAutoGUI cannot click on point (1400, 800) outside screen. (Width: 1366, Height: 768)

After some debugging I found that in activate_cdp_mode(url) an additional virtual screen is created right here. I'm not sure what the idea is here and if it's a bug, but after I commented out this line, my code worked