Papers by Dr. Anuj Mansata
Aim: The aim of the study was to evaluate the influence of aspirin on post‑extraction bleeding in... more Aim: The aim of the study was to evaluate the influence of aspirin on post‑extraction bleeding in a clinical setup.
Materials and Methods: Two hundred patients aged between 50 and 65 years who were indicated for dental extraction for endodontic reason were selected from the outpatient department of Oral and Maxillofacial Surgery. The patients
were randomly divided into aspirin continuing group (group A) and aspirin discontinuing group (group B). After checking all the vital signs, the extractions were carried out. Bleeding time and clotting time were recorded for evaluation by Chi‑square test.
Results: Chi‑square test revealed that the bleeding time increased (3.8 ± 0.75) in group A patients continued with the aspirin therapy where as group B discontinued aspirin. Similarly, the clotting time increased in group B patients and decreased in group A patients. But in both the groups, bleeding and clotting time remained within normal limits.
Conclusion: Reviewing most of the dental and medical literature, it can be concluded that there is absolutely no need to discontinue anti-platelet therapy for any ambulatory dental procedure, and even if the practitioner wishes to discontinue, it should not be for more than 3 days. This is also stated in the guidelines of the American Heart Association.
Introduction: Mast cells (MC) are phylogenetically old cells which are distributed throughout the... more Introduction: Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism and, on the whole, occupy roughly the volume of the spleen. They have long been recognized as key cells of type I hypersensitivity reactions.
Objective: The objective of this work was to quantify Mast Cells (MC) numbers in human periapical lesions with the purpose to shed light on their role in the pathogenesis of these lesions.
Materials and Methods: In this study, we used toluidine blue as special stain to stain mast cells in 25 cases each of periapical granulomas and cysts. The number of MCs was quantified. Statistical analysis was done and mast cells numbers were compared.
Results: On comparing mast cell numbers, it was found that cysts contained more mast cells than granulomas. Increased number of mast cells (MC) suggests that they play definite active role in the pathogenesis of the periapical inflammatory lesions. The potential role of MCs related with the initiation, development, and persistence of the periapical inflammatory process are discussed here.
Background: Among the types of adult stem cells, those derived from tooth structures have been re... more Background: Among the types of adult stem cells, those derived from tooth structures have been receiving the attention of researchers over the past decade and inspiring hope for practical applications in the future. Dental stem cells are a valuable source of stem cells and are found in teeth with healthy pulp.
Till date five different human dental stem cells have been isolated and characterized: Dental Pulp Stem Cells (DPSCs), Stem Cells From Exfoliated Deciduous Teeth (SHED), Periodontal Ligament Stem Cells (PDLSCs), Stem Cells From Apical Papilla (SCAP), and Dental Follicle Progenitor Cells (DFPCs). The discovery of dental stem cells and recent advances in cellular and molecular biology have led to the development of novel therapeutic strategies that aim at the regeneration of oral tissues that were injured by disease or trauma.
Dental Stem cells research has given newer conceptual approach to therapy of various diseases, named “regenerative dentistry” and it will have its place in the clinical practice of dentistry in the future. This review discusses the types of dental stem cells, their banking and their possible application in treatment of diseases in future.
Background: Ameloblastoma is a benign odontogenic neoplasm which frequently affects the mandible.... more Background: Ameloblastoma is a benign odontogenic neoplasm which frequently affects the mandible. The term ameloblastoma includes several clinicoradiological and histological types. Apart from the most commonly encountered clinicopathologic models, there are few variants, whose biological profile is unknown or not elicited.
Unicystic ameloblastoma refers to those cystic lesions that show clinical, radiographic, or gross features of a jaw cyst but on histologic examination show a typical ameloblastomatous epithelium lining the cyst cavity, with or without luminal and/or mural tumor proliferation. Unicystic ameloblastoma is a less encountered variant of the ameloblastoma and is believed to be less aggressive. Here we report a distinctive case of mural unicystic ameloblastoma of mandible of a 37 year old male with the radiographic presentation of multilocular radiolucency.
Background : Radiography offers a noninvasive simple method to perform age estimation. Kvaal deve... more Background : Radiography offers a noninvasive simple method to perform age estimation. Kvaal developed a method for estimating the chronological age of an adult from measurements of the size of the pulp as observed on periapical radiographs.
Aim : To evaluate feasibility of Kvaal's dental age estimation technique on digital orthopantomographs on a small population of Gujarat and determine if population specific formula improved age estimation.
Materials and Method :- 30 digital orthopantomograps (OPG) were selected between age of 15 -60 years after a set of inclusion and exclusion criteria. Measurements of pulp width and length and several other ratios of six teeth namely maxillary central incisor, lateral incisor and second premolar and mandibular lateral incisor, canine and first premolar of either left or right side were calculated from digital OPG. These ratios were substituted in Kvaal's formula and also in the population specific formulae derived in this study using principal component regression analysis. Statistical analysis were done using Student's t-test.
Results : According to our study among all the teeth the results of age estimation are better with maxillary lateral incisors and also that among maxillary and mandibular teeth, maxillary
teeth are better predictors of age. Indian formulae derived in this study produced smaller errors(+ 5.49 - 8.56) in estimation of age than Kvaal's original formula (+9.61-23.80).
Conclusion: Kvaal's technique of age estimation in adults can be applied on data obtained from OPG instead
of the typical apical radiographs. Population specific regression formulae are required for estimating age and that formula of one population cannot be applied on other population.
Background: Odontometric measurements seem to be most reliable method for gender determination si... more Background: Odontometric measurements seem to be most reliable method for gender determination since teeth represent the most durable and resilient part of the skeleton.
Aim: To investigate the accuracy of a method with which gender can be differentiated by odontometric analysis of maxillary and mandibular canine teeth in a sample of adult Indian population.
Materials and methods: The study was conducted on 60 subjects (30 males, 30 females) of 16 to 25 years age group. Mesio-distal and labio-lingual dimensions of maxillary and mandibular canines and inter-canine width were measured with vernier calipers. Mandibular canine index and sexual dimorphism were calculated according to formulae. The data were subjected to statistical analysis using ‘t’ test and results were analyzed.
Results: Males showed greater mean dimensions of teeth than females and results were statistically significant. The most sensitive predictors for gender determination were the mandibular inter-canine distance & canine index in the present study. Mandibular canine teeth showed significant and consistent results of sexual dimorphism and hence can be used as an adjunct along with other procedures for sex determination. Regression formulae in present study lead to prediction of gender determination by accuracy of 89.25%, using mandibular canines. The odontometric analysis of canine teeth can provide predictive equations for gender determination in Indian population.
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Papers by Dr. Anuj Mansata
Materials and Methods: Two hundred patients aged between 50 and 65 years who were indicated for dental extraction for endodontic reason were selected from the outpatient department of Oral and Maxillofacial Surgery. The patients
were randomly divided into aspirin continuing group (group A) and aspirin discontinuing group (group B). After checking all the vital signs, the extractions were carried out. Bleeding time and clotting time were recorded for evaluation by Chi‑square test.
Results: Chi‑square test revealed that the bleeding time increased (3.8 ± 0.75) in group A patients continued with the aspirin therapy where as group B discontinued aspirin. Similarly, the clotting time increased in group B patients and decreased in group A patients. But in both the groups, bleeding and clotting time remained within normal limits.
Conclusion: Reviewing most of the dental and medical literature, it can be concluded that there is absolutely no need to discontinue anti-platelet therapy for any ambulatory dental procedure, and even if the practitioner wishes to discontinue, it should not be for more than 3 days. This is also stated in the guidelines of the American Heart Association.
Objective: The objective of this work was to quantify Mast Cells (MC) numbers in human periapical lesions with the purpose to shed light on their role in the pathogenesis of these lesions.
Materials and Methods: In this study, we used toluidine blue as special stain to stain mast cells in 25 cases each of periapical granulomas and cysts. The number of MCs was quantified. Statistical analysis was done and mast cells numbers were compared.
Results: On comparing mast cell numbers, it was found that cysts contained more mast cells than granulomas. Increased number of mast cells (MC) suggests that they play definite active role in the pathogenesis of the periapical inflammatory lesions. The potential role of MCs related with the initiation, development, and persistence of the periapical inflammatory process are discussed here.
Till date five different human dental stem cells have been isolated and characterized: Dental Pulp Stem Cells (DPSCs), Stem Cells From Exfoliated Deciduous Teeth (SHED), Periodontal Ligament Stem Cells (PDLSCs), Stem Cells From Apical Papilla (SCAP), and Dental Follicle Progenitor Cells (DFPCs). The discovery of dental stem cells and recent advances in cellular and molecular biology have led to the development of novel therapeutic strategies that aim at the regeneration of oral tissues that were injured by disease or trauma.
Dental Stem cells research has given newer conceptual approach to therapy of various diseases, named “regenerative dentistry” and it will have its place in the clinical practice of dentistry in the future. This review discusses the types of dental stem cells, their banking and their possible application in treatment of diseases in future.
Unicystic ameloblastoma refers to those cystic lesions that show clinical, radiographic, or gross features of a jaw cyst but on histologic examination show a typical ameloblastomatous epithelium lining the cyst cavity, with or without luminal and/or mural tumor proliferation. Unicystic ameloblastoma is a less encountered variant of the ameloblastoma and is believed to be less aggressive. Here we report a distinctive case of mural unicystic ameloblastoma of mandible of a 37 year old male with the radiographic presentation of multilocular radiolucency.
Aim : To evaluate feasibility of Kvaal's dental age estimation technique on digital orthopantomographs on a small population of Gujarat and determine if population specific formula improved age estimation.
Materials and Method :- 30 digital orthopantomograps (OPG) were selected between age of 15 -60 years after a set of inclusion and exclusion criteria. Measurements of pulp width and length and several other ratios of six teeth namely maxillary central incisor, lateral incisor and second premolar and mandibular lateral incisor, canine and first premolar of either left or right side were calculated from digital OPG. These ratios were substituted in Kvaal's formula and also in the population specific formulae derived in this study using principal component regression analysis. Statistical analysis were done using Student's t-test.
Results : According to our study among all the teeth the results of age estimation are better with maxillary lateral incisors and also that among maxillary and mandibular teeth, maxillary
teeth are better predictors of age. Indian formulae derived in this study produced smaller errors(+ 5.49 - 8.56) in estimation of age than Kvaal's original formula (+9.61-23.80).
Conclusion: Kvaal's technique of age estimation in adults can be applied on data obtained from OPG instead
of the typical apical radiographs. Population specific regression formulae are required for estimating age and that formula of one population cannot be applied on other population.
Aim: To investigate the accuracy of a method with which gender can be differentiated by odontometric analysis of maxillary and mandibular canine teeth in a sample of adult Indian population.
Materials and methods: The study was conducted on 60 subjects (30 males, 30 females) of 16 to 25 years age group. Mesio-distal and labio-lingual dimensions of maxillary and mandibular canines and inter-canine width were measured with vernier calipers. Mandibular canine index and sexual dimorphism were calculated according to formulae. The data were subjected to statistical analysis using ‘t’ test and results were analyzed.
Results: Males showed greater mean dimensions of teeth than females and results were statistically significant. The most sensitive predictors for gender determination were the mandibular inter-canine distance & canine index in the present study. Mandibular canine teeth showed significant and consistent results of sexual dimorphism and hence can be used as an adjunct along with other procedures for sex determination. Regression formulae in present study lead to prediction of gender determination by accuracy of 89.25%, using mandibular canines. The odontometric analysis of canine teeth can provide predictive equations for gender determination in Indian population.
Materials and Methods: Two hundred patients aged between 50 and 65 years who were indicated for dental extraction for endodontic reason were selected from the outpatient department of Oral and Maxillofacial Surgery. The patients
were randomly divided into aspirin continuing group (group A) and aspirin discontinuing group (group B). After checking all the vital signs, the extractions were carried out. Bleeding time and clotting time were recorded for evaluation by Chi‑square test.
Results: Chi‑square test revealed that the bleeding time increased (3.8 ± 0.75) in group A patients continued with the aspirin therapy where as group B discontinued aspirin. Similarly, the clotting time increased in group B patients and decreased in group A patients. But in both the groups, bleeding and clotting time remained within normal limits.
Conclusion: Reviewing most of the dental and medical literature, it can be concluded that there is absolutely no need to discontinue anti-platelet therapy for any ambulatory dental procedure, and even if the practitioner wishes to discontinue, it should not be for more than 3 days. This is also stated in the guidelines of the American Heart Association.
Objective: The objective of this work was to quantify Mast Cells (MC) numbers in human periapical lesions with the purpose to shed light on their role in the pathogenesis of these lesions.
Materials and Methods: In this study, we used toluidine blue as special stain to stain mast cells in 25 cases each of periapical granulomas and cysts. The number of MCs was quantified. Statistical analysis was done and mast cells numbers were compared.
Results: On comparing mast cell numbers, it was found that cysts contained more mast cells than granulomas. Increased number of mast cells (MC) suggests that they play definite active role in the pathogenesis of the periapical inflammatory lesions. The potential role of MCs related with the initiation, development, and persistence of the periapical inflammatory process are discussed here.
Till date five different human dental stem cells have been isolated and characterized: Dental Pulp Stem Cells (DPSCs), Stem Cells From Exfoliated Deciduous Teeth (SHED), Periodontal Ligament Stem Cells (PDLSCs), Stem Cells From Apical Papilla (SCAP), and Dental Follicle Progenitor Cells (DFPCs). The discovery of dental stem cells and recent advances in cellular and molecular biology have led to the development of novel therapeutic strategies that aim at the regeneration of oral tissues that were injured by disease or trauma.
Dental Stem cells research has given newer conceptual approach to therapy of various diseases, named “regenerative dentistry” and it will have its place in the clinical practice of dentistry in the future. This review discusses the types of dental stem cells, their banking and their possible application in treatment of diseases in future.
Unicystic ameloblastoma refers to those cystic lesions that show clinical, radiographic, or gross features of a jaw cyst but on histologic examination show a typical ameloblastomatous epithelium lining the cyst cavity, with or without luminal and/or mural tumor proliferation. Unicystic ameloblastoma is a less encountered variant of the ameloblastoma and is believed to be less aggressive. Here we report a distinctive case of mural unicystic ameloblastoma of mandible of a 37 year old male with the radiographic presentation of multilocular radiolucency.
Aim : To evaluate feasibility of Kvaal's dental age estimation technique on digital orthopantomographs on a small population of Gujarat and determine if population specific formula improved age estimation.
Materials and Method :- 30 digital orthopantomograps (OPG) were selected between age of 15 -60 years after a set of inclusion and exclusion criteria. Measurements of pulp width and length and several other ratios of six teeth namely maxillary central incisor, lateral incisor and second premolar and mandibular lateral incisor, canine and first premolar of either left or right side were calculated from digital OPG. These ratios were substituted in Kvaal's formula and also in the population specific formulae derived in this study using principal component regression analysis. Statistical analysis were done using Student's t-test.
Results : According to our study among all the teeth the results of age estimation are better with maxillary lateral incisors and also that among maxillary and mandibular teeth, maxillary
teeth are better predictors of age. Indian formulae derived in this study produced smaller errors(+ 5.49 - 8.56) in estimation of age than Kvaal's original formula (+9.61-23.80).
Conclusion: Kvaal's technique of age estimation in adults can be applied on data obtained from OPG instead
of the typical apical radiographs. Population specific regression formulae are required for estimating age and that formula of one population cannot be applied on other population.
Aim: To investigate the accuracy of a method with which gender can be differentiated by odontometric analysis of maxillary and mandibular canine teeth in a sample of adult Indian population.
Materials and methods: The study was conducted on 60 subjects (30 males, 30 females) of 16 to 25 years age group. Mesio-distal and labio-lingual dimensions of maxillary and mandibular canines and inter-canine width were measured with vernier calipers. Mandibular canine index and sexual dimorphism were calculated according to formulae. The data were subjected to statistical analysis using ‘t’ test and results were analyzed.
Results: Males showed greater mean dimensions of teeth than females and results were statistically significant. The most sensitive predictors for gender determination were the mandibular inter-canine distance & canine index in the present study. Mandibular canine teeth showed significant and consistent results of sexual dimorphism and hence can be used as an adjunct along with other procedures for sex determination. Regression formulae in present study lead to prediction of gender determination by accuracy of 89.25%, using mandibular canines. The odontometric analysis of canine teeth can provide predictive equations for gender determination in Indian population.