The University of South Carolina’s School of Information Science will compile local, regional, and national health resources to create a centralized, visible, and sustainable online LGBTQIA+ consumer health information guide. Libraries have the potential to offer safe spaces for LGBTQIA+ individuals, who have historically lacked access to crucial health information, to seek health information and receive professional guidance. Despite this potential, LGBTQIA+ people have encountered barriers to library use, including insufficient collections and services. Building off a previous IMLS grant, the project will leverage established partnerships, including a national network of LGBTQIA+ community leaders, public library workers, and health sciences librarians—and a partnership with the Network of the National Library of Medicine Region 2 Regional Medical Library—to support the guide’s creation and sustainability. The primary beneficiaries are LGBTQIA+ people nationwide, who can gain crucial health insights, and librarians, who will deepen their understanding of LGBTQIA+ needs and strengthen community trust.