Papers by Farman Ullah Khan
Open journal of chemistry, Jun 30, 2019
The graphene and graphene oxide are latest and advanced materials with wide applications in envir... more The graphene and graphene oxide are latest and advanced materials with wide applications in environment, medical applications, industries, defense applications. We have synthesized graphene oxide from graphite flakes by modifying Hummer method in which we used NaNO 2 instead of NaNO 3 . Then we characterized our samples with X-Ray Diffractometry (XRD), Scanning-Electron Microscopy (SEM) and Fourier-Transform Infrared-Spectroscopy (FT-IR). These results confirmed the formation of graphene oxide also through this process. This graphene oxide can further be used for future applications in wastewater treatment and biomedical applications.
International Journal of Biosciences (IJB), 2013
Journal of Medicinal Plants Research, Sep 4, 2010
The present study documents the traditional knowledge of medicinal plant species used in Darra Ad... more The present study documents the traditional knowledge of medicinal plant species used in Darra Adam Khel NWFP Pakistan. We have documented the use of 34 species belonging to 25 families. The dominant families are Lamiaceae with 3 species, followed by Monaceae with 3 species, Mimosaceae, Apocynaceae, Asteraceae and Liliaceae with 2 species each. These medicinal plants are used to cure about 30 -35 types of ailment. The main ailments in this area were cough, diabetes, stomach problem, headache, jaundice, toothache and skin diseases. Leaves are the most frequently used plant part against diseases. It is noticed during investigation that Rumex hastatus and Monotheca buxifolia are the endangered species in the area and special care is needed. The studies carried out for the first time in this area, gathered information are documented about traditional remedies before they are lost.
Chemistry - A European Journal, 2010
Engineering and applied science letters, Dec 30, 2018
Journal of Medicinal Plants Research, 2010
Proximate composition and levels of metals in four commonly consumed species, Sonchus eruca, Meli... more Proximate composition and levels of metals in four commonly consumed species, Sonchus eruca, Melia azadirchta, Withania coagulans and Fagonia indica, were investigated for the first time. Ash, carbohydrate, protein, fiber, fat and moisture were arranged on dry basis, while Cu, Pb, Co, Cd, Fe, Cr, Mg and Na were also investigated in metal analysis using association of official analytical chemists (AOAC) methods and atomic absorption spectrometric techniques. However, M. azadirachta was found to be rich in fiber content and energy values. The results of metal analysis showed that M. azadirachta had the highest concentrations of the metals like Cu, Mn, Cr and Fe while S. eruca contain higher concentration of Na as compared to other three species.
Natural Product Communications, 2008
Two new bisflavan-3-ols, named colletinin A (1) and 2,2″-diepicolletinin A (2) have been isolated... more Two new bisflavan-3-ols, named colletinin A (1) and 2,2″-diepicolletinin A (2) have been isolated from Rhododendron collettianum. Their structures were determined by means of 1D and 2D NMR analysis, aided by HREIMS data. The relative configuration was determined by means of 1H-1H NOESY correlation but the absolute configuration could not be established.
ACS combinatorial science, Jan 12, 2012
The synthesis of a unique isoindoline- and tetrahydroisoquinoline (THIQ)-containing tricyclic sul... more The synthesis of a unique isoindoline- and tetrahydroisoquinoline (THIQ)-containing tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy is reported. Both isoindoline and THIQ rings are installed through a Heck reaction on a vinylsulfonamide, followed by one-pot deprotection and intramolecular aza-Michael reaction. Subsequent cyclization with either paraformaldehyde condensation or 1,1'-carbonyldiimidazole coupling generates a variety of tricyclic sultams. Overall, a 160-member library of these sultams, together with their isoindolines/THIQ and secondary sulfonamides precursors, were constructed using this strategy.
Chemical and Pharmaceutical Bulletin, 2004
Chemical and Pharmaceutical Bulletin, 2003
In the course of our continuing research on biologically active compounds from Euphorbia decipien... more In the course of our continuing research on biologically active compounds from Euphorbia decipiens, a series of studies on the isolation and structure elucidation of secondary metabolites from this plant have been performed. 1-6) Continuing the previous studies, in this paper we report on the isolation and structure of three new diterpenes from the whole plant of Euphorbia decipiens. Compounds 1 and 3 showed activity against prolyl endopeptidase. Prolyl endopeptidase (PEP, EC 3.4.21.26) is the only serine protease which is known to cleave a peptide substrate in the C-terminal side of a proline residue. 7) Compound 2 showed inhibitory activity against the activity of urease. The enzyme urease has been implicated in a variety of pathological conditions, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. 8) Results and Discussion Compound 1 was assigned the molecular formula C 35 H 44 O 11 on the basis of high-resolution electron impact mass spectrometery (HR-EI-MS). Its IR spectra showed a characteristic absorption for carbonyl groups at 1740 cm Ϫ1 and those at 1600, 1570 and 710 cm Ϫ1 for a benzene ring. A sharp absorption at 3460 cm Ϫ1 indicated a non-hydrogenbonded hydroxyl group in the molecule. In the EI-MS spectrum the ions at m/z 580, 520, 460 and 400 indicated the presence of acetate groups which were eliminated from the molecular ion at m/zϭ640 in the form of acetic acid. The peak at m/zϭ105 (C 6 H 5 CO) ϩ , 121 (C 6 H 5 COO) ϩ and at m/z 71 (C 3 H 7 CO) indicated the presence of a benzoate and butanoate ester group respectively in the molecule. The 1 H-NMR of 1 in CDCl 3 (Table 1) showed two singlets for acetate methyl groups at d 2.18 and 2.07. There were three signals due to protons geminal to ester groups which were observed as a doublet at d 5.68 (d, Jϭ10.7 Hz, H-5), a doublet at d 4.52 (Jϭ6.0 Hz, H-7) and a triplet at d 5.55 (t, Jϭ3.4 Hz, H-3). The spectrum also showed three methyl signals in the molecule, comprised of a secondary methyl at d 0.88 (d, Jϭ7.4 Hz, 3ϫH-16), one olefinic methyl at d 1.91 (s, H 3-19) and one tertiary methyl at d 1.34 (s, H 3-20); these signals seems to be geminal to an oxygen bearing group. The vicinal olefinic protons showing signals at d 6.35 (br t,
Biomedical Journal of Scientific & Technical Research, 2021
Cellulose nanocrystals (CNCs) is one of the outstanding nanomaterial. So far, much researcher now... more Cellulose nanocrystals (CNCs) is one of the outstanding nanomaterial. So far, much researcher nowadays has been developed their properties. These properties make CNCs a promising resource to replace fossil resources for the production of industrial materials and chemicals. Here, we firstly modified cellulose nanocrystals with 3-Glycidoxypropyltrimethoxy (KH-560) silane coupling agent. Chemical composition and surface morphologies of cellulose nanocrystals were analyzed and characterized by FT-IR, and SEM. The result indicated that polar hydroxyl groups were successfully introduced on the cellulose nanocrystals surface. The SEM results confirmed silane coupling agent was successfully grafted on cellulose nanocrystals. Modified CNCs demonstrated an excellent tensile strength and modulus exhibited by 1wt% modified cellulose nanocrystals composites. This novel procedure improves the dispersion of cellulose nanocrystals by modification and at the same time enhance the interfacial adhesion. Result shows increases more over than the native cellulose nanocrystals by modifying CNCs with KH-560 coupling agent. This study lays a foundation towards full polymers fabrication and consumptions most desirable in adhesive and mechanical industrial fields.
Biomedical Journal of Scientific & Technical Research, 2020
We synthesized the cellulose nanocrystals (CNCs) by using cotton as a raw material, then it was m... more We synthesized the cellulose nanocrystals (CNCs) by using cotton as a raw material, then it was modified with 2-carboxyethyl acrylate to improve its adhesion and thermal properties. CNCs was chosen as a modifier to improve the interfacial adhesion between the reinforced nanocrystals and E-51 epoxy resin system. This gives a better modulus of elasticity, a lower coefficient of energy, and thermal expansion. Significant improvements in modulus properties, strength, transparency and thermal stability were observed with modified cellulose nanocrystals (MCNCs) compared with the standard sample. SEM, and transmission electron microscope (TEM), powder diffraction (XRD), (TGA and DTG) and Fourier transform infrared spectroscopy (FTIR) were used for the isolation of synthetic (native and modified) cellulose nanocrystals. In addition, the MCNCs adhesion properties with E-51 (Bisphenol A diglycidyl ether) epoxy resins were also investigated using the Zwick/Roell Z020 model.
Natural Product Communications, 2016
Nepeta suavis is used in traditional medicine for treatment of abdominal spasm (colic). The tricy... more Nepeta suavis is used in traditional medicine for treatment of abdominal spasm (colic). The tricyclic clerodane type diterpene, nepetolide, isolated for the first time from Nepeta suavis. was evaluated for Ca++ antagonist and antispasmodic activities. When studied in isolated rabbit jejunum, nepetolide caused concentration-dependent (0.03–100 μM) relaxation of spontaneous and high K+ (80 mM)-induced contractions, like that caused by verapamil, indicating that nepetolide exhibits spasmolytic activity, possibly mediated through Ca++ channel blocking action, which provides scientific explanation for the medicinal application of Nepeta suavis as an antispasmodic agent.
International journal of nanomedicine, 2018
Silver nanotechnology has received tremendous attention in recent years, owing to its wide range ... more Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer. The mechanism of action of AgNPs in different biological systems still remains enigmatic. Here, due to limited available literature, we only focused on AgNPs mechanism in biological systems including human (wound healing and apoptosis), bacteria, and viruses which may open new windows for future research to ensure the ve...
The current study was carried out to evaluate the antibacterial activities of methanolic extract ... more The current study was carried out to evaluate the antibacterial activities of methanolic extract and various fractions of A. javanica. The fractions of A. javanica (Burm. f.) Juss. ex Schult., were evaluated against six bacterial strain, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Shigella flexenari and Salmonella typhi. Some of the solvent extracts of the plant showed significant activity against some bacteria as compared to standard drug used. The observed antibacterial activities may be due to the presence of some secondary metabolites such as tannins, alkaloids and flavonoids etc. The results are very significant in delivering safe and cheap use of the plant in the treatment of wounds healings and for the control of dysentery and diarrhea. INTRODUCTION and seeds are used in case of diarrhea and haematuria in
Chemical and Pharmaceutical Bulletin, 2004
Two new clerodane-type diterpenoids trivially named as ballotenic acid (1) and ballodiolic acid (... more Two new clerodane-type diterpenoids trivially named as ballotenic acid (1) and ballodiolic acid (2) have been isolated from Ballota limbata along with three the known compounds; b b-amyrin, oleanolic acid, and b b-sitosterol. The structure elucidation of the new compounds was based primarily on two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect (NOE) experiments. Compounds 1 and 2 displayed inhibitory potential against lipoxygenase enzyme in a concentration-dependent fashion with IC 50 values of 99.6 m mM and 38.3 m mM, respectively.
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Papers by Farman Ullah Khan