Figure 1.
Meta-analysis of the association between the proprotein convertase subtilisin/kexin type 9 (PCSK9) loss-of-function variant rs11591147 (R46L) and 28-d mortality in all cohorts of patients with sepsis. AA = Alternate/Alternate, AAF = alternate allele fraction, GEN-SEP = GENetics of SEPsis, GHS = Geisinger Health System, HUNT = Trøndelag Health Study, KP GERA = Kaiser Permanente Resource for Genetic Epidemiology Research on Adult Health and Aging, META = meta-analysis, OR = odds ratio, RA = Reference/Alternate, RR = Reference/Reference, SPH = St. Paul’s Hospital, UKB = U.K. Biobank, VASST = Vasopressin and Septic Shock Trial.